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    CDC2L2 cell division cycle 2-like 2 (PITSLRE proteins) [ Homo sapiens ]

    Gene ID: 985, discontinued on 12-Jun-2007 This record was replaced with Gene ID: 728642
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    Summary

    Official Symbol
    CDC2L2provided by HGNC
    Official Full Name
    cell division cycle 2-like 2 (PITSLRE proteins)provided by HGNC
    Primary source
    HGNC:1730
    See related
    HPRD:00308; MIM:116951
    Gene type
    protein coding
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC2L3; p58GTA; PITSLRE; CDK11-p46; CDK11-p58; CDK11-p110; MGC131975
    Summary
    This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far.
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    Genomic context

    Location :
    1p36.33
    See CDC2L2 in MapViewer
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    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    General gene information

    Genotypes

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    General protein information

    Names
    cell division cycle 2-like 2
    PITSLRE B
    PITSLRE protein kinase beta
    cell division cycle 2-like protein kinase 2
    PITSLRE serine/threonine-protein kinase CDC2L2
    galactosyltransferase-associated protein kinase p58/GTA
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF080694.1 AAC95297.1
      AAC95298.1
      AAC95299.1
      AAC95300.1
    genomic AF080695.1 AAC95299.1
    genomic AF080697.1 AAC95301.1
      AAC95302.1
      AAC95303.1
      AAC95304.1
    genomic AF092426.1 None
    genomic AL031282.1 CAI20030.1
      CAI20031.1
      CAI20032.1
      CAI20033.1
      CAI20034.1
      CAI20035.1
    genomic AL031282.1 CAI20030.1
      CAI20031.1
      CAI20032.1
      CAI20033.1
      CAI20034.1
      CAI20035.1
    genomic CH471183.1 EAW56161.1
      EAW56162.1
      EAW56163.1
      EAW56164.1
      EAW56165.1
      EAW56166.1
      EAW56167.1
      EAW56168.1
    mRNA AB209095.1 BAD92332.1
    mRNA AF067518.1 AAC72083.1
    mRNA AF067519.1 AAC72084.1
    mRNA AF067520.1 AAC72085.1
    mRNA AF067521.1 AAC72086.1
    mRNA AF067522.1 AAC72087.1
    mRNA AF067523.1 AAC72088.1
    mRNA AF067524.1 AAC72089.1
    mRNA AF067526.1 AAC72091.1
    mRNA AF067527.1 AAC72092.1
    mRNA AF067528.1 AAC72093.1
    mRNA AF067529.1 AAC72094.1
    mRNA BC014464.1 AAH14464.1
    mRNA BC028187.1 AAH28187.1
    mRNA BC054019.1 None
    mRNA BC094827.1 AAH94827.1
    mRNA BC104661.1 AAI04662.1
    mRNA BC110905.1 AAI10906.1
    mRNA U04819.1 AAA19585.1
    mRNA U07704.1 AAA19594.1
    mRNA U07705.1 AAA19595.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05C84 GenPept UniProtKB/TrEMBL:Q05C84
    Q2TAJ0 GenPept UniProtKB/TrEMBL:Q2TAJ0
    Q3SWV2 GenPept UniProtKB/TrEMBL:Q3SWV2
    Q4VBY6 GenPept UniProtKB/TrEMBL:Q4VBY6
    Q59GL4 GenPept UniProtKB/TrEMBL:Q59GL4
    Q5QPQ9 GenPept UniProtKB/TrEMBL:Q5QPQ9
    Q5QPR3 GenPept UniProtKB/TrEMBL:Q5QPR3
    Q5QPR4 GenPept UniProtKB/TrEMBL:Q5QPR4
    Q96CA8 GenPept UniProtKB/TrEMBL:Q96CA8
    Q9UQ88 GenPept UniProtKB/Swiss-Prot:Q9UQ88
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    Additional Links

    Gene LinkOut

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