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TRIM14 tripartite motif containing 14 [ Homo sapiens (human) ]

Gene ID: 9830, updated on 7-Apr-2024

Summary

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Official Symbol
TRIM14provided by HGNC
Official Full Name
tripartite motif containing 14provided by HGNC
Primary source
HGNC:HGNC:16283
See related
Ensembl:ENSG00000106785 MIM:606556; AllianceGenome:HGNC:16283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in colon (RPKM 8.0), small intestine (RPKM 7.7) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See TRIM14 in Genome Data Viewer
Location:
9q22.33
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (98035797..98119222, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (110207739..110291169, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100846635..100881504, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20110 Neighboring gene uncharacterized LOC124902225 Neighboring gene acidic nuclear phosphoprotein 32 family member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28681 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:100797789-100798988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28684 Neighboring gene RNA, U6 small nuclear 918, pseudogene Neighboring gene uncharacterized LOC124902227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28686 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100833954-100834454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100836915-100837721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100849215-100849889 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100849890-100850563 Neighboring gene N-acetylneuraminate synthase Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:100852934-100853493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28692 Neighboring gene coronin 2A Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:100921913-100922413 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100924760-100925260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100933363-100934198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100935871-100936704 Neighboring gene Sharpr-MPRA regulatory region 7304 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100953772-100954426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100957663-100958179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100960535-100961402 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100961403-100962270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100963511-100964012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100964013-100964512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100965136-100965636 Neighboring gene Sharpr-MPRA regulatory region 378 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:100984952-100986151 Neighboring gene TBC1 domain family member 2 Neighboring gene microRNA 6854

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TRIM14 regulates melanoma malignancy via PTEN/PI3K/AKT and STAT3 pathways. Chen J, et al. Aging (Albany NY), 2021 May 11. PMID 33982666, Free PMC Article
  2. Human TRIM14 protects transgenic mice from influenza A viral infection without activation of other innate immunity pathways. Nenasheva VV, et al. Genes Immun, 2021 May. PMID 33864033
  3. Tripartite motif‑containing 14 regulates cell proliferation and apoptosis in cervical cancer via the Akt signaling pathway. Diao W, et al. Mol Med Rep, 2020 Dec. PMID 33174608, Free PMC Article
  4. Trim14 promotes autophagy and chemotherapy resistance of gastric cancer cells by regulating AMPK/mTOR pathway. Xiao F, et al. Drug Dev Res, 2020 Aug. PMID 32096264
  5. The TRIM14 PRYSPRY domain mediates protein interaction via its basic interface. Yu Y, et al. FEBS Lett, 2019 May. PMID 30973643

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM14 Overexpression Induces Chemoresistance and Malignant Behaviors of Hepatocellular Carcinoma Cells by Activating the STAT3/HIF-1alpha Pathway.
    Title: TRIM14 Overexpression Induces Chemoresistance and Malignant Behaviors of Hepatocellular Carcinoma Cells by Activating the STAT3/HIF-1α Pathway.
  2. Circular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis.
    Title: Circular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis.
  3. Human mesenchymal stem cells derived exosomes inhibit the growth of acute myeloid leukemia cells via regulating miR-23b-5p/TRIM14 pathway.
    Title: Human mesenchymal stem cells derived exosomes inhibit the growth of acute myeloid leukemia cells via regulating miR-23b-5p/TRIM14 pathway.
  4. miR-671-5p repressed progression of papillary thyroid carcinoma via TRIM14.
    Title: miR-671-5p repressed progression of papillary thyroid carcinoma via TRIM14.
  5. Human TRIM14 protects transgenic mice from influenza A viral infection without activation of other innate immunity pathways.
    Title: Human TRIM14 protects transgenic mice from influenza A viral infection without activation of other innate immunity pathways.
  6. miR-4443 targets TRIM14 to suppress metastasis and energy metabolism of papillary thyroid carcinoma (PTC) in vitro.
    Title: miR-4443 targets TRIM14 to suppress metastasis and energy metabolism of papillary thyroid carcinoma (PTC) in vitro.
  7. Trim14 promotes autophagy and chemotherapy resistance of gastric cancer cells by regulating AMPK/mTOR pathway.
    Title: Trim14 promotes autophagy and chemotherapy resistance of gastric cancer cells by regulating AMPK/mTOR pathway.
  8. TRIM14 regulates melanoma malignancy via PTEN/PI3K/AKT and STAT3 pathways.
    Title: TRIM14 regulates melanoma malignancy via PTEN/PI3K/AKT and STAT3 pathways.
  9. TRIM14 may be a prognostic factor and oncogene in papillary thyroid carcinoma
    Title: Tripartite motif containing 14: An oncogene in papillary thyroid carcinoma.
  10. The crystal structure of the TRIM14 PRYSPRY domain was solved, and found a positively charged surface that may mediate its partner specificity. TRIM14 PRYSPRY domain binds to acidic peptides, and the analysis of the reported partners of TRIM14 is consistent with this assumption.
    Title: The TRIM14 PRYSPRY domain mediates protein interaction via its basic interface.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0129

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of viral transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tripartite motif-containing protein 14
Names
tripartite motif protein TRIM14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014788.4 → NP_055603.2  tripartite motif-containing protein 14

    See identical proteins and their annotated locations for NP_055603.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AA469446, AK292825, AL137073, BF797334
    Consensus CDS
    CCDS6734.1
    UniProtKB/Swiss-Prot
    A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
    Related
    ENSP00000344208.2, ENST00000341469.7
    Conserved Domains (1) summary
    cd13738
    Location:269 → 441
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

  2. NM_033219.3 → NP_150088.1  tripartite motif-containing protein 14

    See identical proteins and their annotated locations for NP_150088.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also referred to as alpha) is alternatively spliced in the 3' UTR, compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AA469446, AF220130, AL137073, BF797334
    Consensus CDS
    CCDS6734.1
    UniProtKB/Swiss-Prot
    A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
    Related
    ENSP00000343990.3, ENST00000342043.3
    Conserved Domains (1) summary
    cd13738
    Location:269 → 441
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    98035797..98119222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424162.1 → XP_047280118.1  tripartite motif-containing protein 14 isoform X1

    UniProtKB/Swiss-Prot
    A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

  2. XM_047424161.1 → XP_047280117.1  tripartite motif-containing protein 14 isoform X1

    UniProtKB/Swiss-Prot
    A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

  3. XM_047424160.1 → XP_047280116.1  tripartite motif-containing protein 14 isoform X1

    UniProtKB/Swiss-Prot
    A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
    Related
    ENSP00000364239.3, ENST00000375098.7

  4. XM_017015353.3 → XP_016870842.1  tripartite motif-containing protein 14 isoform X1

    UniProtKB/Swiss-Prot
    A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
    Conserved Domains (1) summary
    cd13738
    Location:269 → 441
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

  5. XM_005252320.5 → XP_005252377.1  tripartite motif-containing protein 14 isoform X1

    See identical proteins and their annotated locations for XP_005252377.1

    UniProtKB/Swiss-Prot
    A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
    Conserved Domains (1) summary
    cd13738
    Location:269 → 441
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

  6. XM_047424163.1 → XP_047280119.1  tripartite motif-containing protein 14 isoform X2

  7. XM_047424164.1 → XP_047280120.1  tripartite motif-containing protein 14 isoform X2

  8. XM_011519244.3 → XP_011517546.1  tripartite motif-containing protein 14 isoform X3

    Conserved Domains (1) summary
    cd13738
    Location:112 → 284
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

RNA

  1. XR_929880.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    110207739..110291169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364293.1 → XP_054220268.1  tripartite motif-containing protein 14 isoform X1

    UniProtKB/Swiss-Prot
    A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

  2. XM_054364292.1 → XP_054220267.1  tripartite motif-containing protein 14 isoform X1

    UniProtKB/Swiss-Prot
    A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

  3. XM_054364291.1 → XP_054220266.1  tripartite motif-containing protein 14 isoform X1

    UniProtKB/Swiss-Prot
    A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

  4. XM_054364290.1 → XP_054220265.1  tripartite motif-containing protein 14 isoform X1

    UniProtKB/Swiss-Prot
    A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

  5. XM_054364289.1 → XP_054220264.1  tripartite motif-containing protein 14 isoform X1

    UniProtKB/Swiss-Prot
    A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

  6. XM_054364294.1 → XP_054220269.1  tripartite motif-containing protein 14 isoform X2

  7. XM_054364295.1 → XP_054220270.1  tripartite motif-containing protein 14 isoform X2

  8. XM_054364296.1 → XP_054220271.1  tripartite motif-containing protein 14 isoform X3

RNA

  1. XR_008488114.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033220.1: Suppressed sequence

    Description
    NM_033220.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

  2. NM_033221.1: Suppressed sequence

    Description
    NM_033221.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which aligns with poorly supported non-consensus splice sites in the 3' coding region.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14142.2 GenPept UniProtKB/Swiss-Prot:Q14142

Gene LinkOut

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