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    TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) [ Homo sapiens ]

    Gene ID: 9804, updated on 8-Jan-2012
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    Summary

    Official Symbol
    TOMM20provided by HGNC
    Official Full Name
    translocase of outer mitochondrial membrane 20 homolog (yeast)provided by HGNC
    Primary source
    HGNC:20947
    Locus tag
    RP4-597N16.2
    See related
    Ensembl:ENSG00000173726; HPRD:03507; MIM:601848; Vega:OTTHUMG00000039619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAS20; MOM19; TOM20
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    Genomic context

    Location :
    1q42
    Sequence :
    Chromosome: 1; NC_000001.10 (235272656..235292256, complement)
    See TOMM20 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100130249 Neighboring gene RNA, Ro-associated Y4 pseudogene 16 Neighboring gene small nucleolar RNA, H/ACA box 14B Neighboring gene RNA binding motif protein 34 Neighboring gene AT rich interactive domain 4B (RBP1-like) Neighboring gene microRNA 4753

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Interaction between the human mitochondrial import receptors Tom20 and Tom70 in vitro suggests a chaperone displacement mechanism. Fan AC, et al. J Biol Chem, 2011 Sep 16. PMID 21771790.
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. Hendrickson SL, et al. PLoS One, 2010 Sep 21. PMID 20877624.
    3. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.
    5. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414.

    See all (25) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. a novel model in which Tom20 binds Tom70 to facilitate preprotein release from the chaperones by competition
      Title: Interaction between the human mitochondrial import receptors Tom20 and Tom70 in vitro suggests a chaperone displacement mechanism.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    3. Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins
      Title: Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins.
    4. the cytosolic domains of Tom20 and Tom22 function to maintain their substrate preproteins unfolded and prevent them from aggregating on the mitochondrial surface
      Title: Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q15388 O00170 AIP    HPRD  PubMed  
    Q15388 P02647 APOA1    HPRD  PubMed  
    Q15388 P46379 BAG6    HPRD  PubMed  
    Q15388 P10415 BCL2    HPRD  PubMed  
    Q15388 Q6P1J9 CDC73    HPRD  PubMed  
    Q15388 P00374 DHFR    HPRD  PubMed  
    Q15388 Q99689 FEZ1    HPRD  PubMed  
    Q15388 P54257 HAP1    HPRD  PubMed  
    Q15388 Q9P2H0 KIAA1377    HPRD  PubMed  
    Q15388 P00480 OTC    HPRD  PubMed  
    Q15388 Q8NEY8 PPHLN1    HPRD  PubMed  
    Q15388 P21246 PTN    HPRD  PubMed  
    Q15388 Q9NS69 TOMM22    HPRD  PubMed  
    Q15388 P25874 UCP1    HPRD  PubMed  
    Q15388 P21796 VDAC1    HPRD  PubMed  
    BioGRID:115144 BioGRID:106832 APOA1    BioGRID  PubMed Two-hybrid 
    BioGRID:115144 BioGRID:113647 BAG6    BioGRID  PubMed Two-hybrid 
    BioGRID:115144 BioGRID:107068 BCL2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115144 BioGRID:114997 FEZ1    BioGRID  PubMed Two-hybrid 
    BioGRID:115144 BioGRID:114480 HAP1    BioGRID  PubMed Two-hybrid 
    BioGRID:115144 BioGRID:121617 KIAA1377    BioGRID  PubMed Two-hybrid 
    BioGRID:115144 BioGRID:111050 OTC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115144 BioGRID:119596 PPHLN1    BioGRID  PubMed Two-hybrid 
    BioGRID:115144 BioGRID:111731 PTN    BioGRID  PubMed Two-hybrid 
    BioGRID:115144 BioGRID:121308 TOMM22    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115144 BioGRID:113197 UCP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115144 BioGRID:113259 VDAC1    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the TOMM20 gene: The TOMM20 gene is conserved in chimpanzee, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and C.elegans.

    Clone Names

    • KIAA0016, MGC117367

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    P-P-bond-hydrolysis-driven protein transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    protein targeting to mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial outer membrane translocase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    mitochondrial outer membrane translocase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    mitochondrial import receptor subunit TOM20 homolog
    Names
    mitochondrial import receptor subunit TOM20 homolog
    mitochondrial 20 kDa outer membrane protein
    outer mitochondrial membrane receptor Tom20
    translocase of outer mitochondrial membrane 20 homolog type II
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014765.2 → NP_055580.1  mitochondrial import receptor subunit TOM20 homolog

      Status: VALIDATED

      Source sequence(s)
      AK289810, BC009886, BC100286, D13641
      Consensus CDS
      CCDS1603.1
      UniProtKB/Swiss-Prot
      Q15388
      Related
      ENSP00000355566, OTTHUMP00000037593, ENST00000366607, OTTHUMT00000095551
      Conserved Domains (1) summary
      cl03428
      Location:1 – 127
      Blast Score: 335
      MAS20; MAS20 protein import receptor

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      235272656..235292256, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      205721246..205740848, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF126962.1 AAF13354.1
    genomic AL732292.12 CAI21937.1
    genomic CH471098.1 EAW70003.1
      EAW70004.1
    genomic CQ871290.1 CAH56826.1
    mRNA AK289810.1 BAF82499.1
    mRNA BC000882.1 AAH00882.1
    mRNA BC009886.2 None
    mRNA BC066335.1 AAH66335.1
    mRNA BC071994.1 AAH71994.1
    mRNA BC100286.1 AAI00287.1
    mRNA BC107851.1 AAI07852.1
    mRNA CR456718.1 CAG32999.1
    mRNA D13641.1 BAA02804.1
    other-genetic DQ891102.2 ABM82028.1
    other-genetic EU176557.1 ABW03358.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    AAB35420.1 GenPept
    Q15388.1 GenPept UniProtKB/Swiss-Prot:Q15388
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
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    Tools
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      Supplemental Content

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      Links

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