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Deptor DEP domain containing MTOR-interacting protein [ Mus musculus (house mouse) ]

Gene ID: 97998, updated on 8-May-2016
Official Symbol
Deptorprovided by MGI
Official Full Name
DEP domain containing MTOR-interacting proteinprovided by MGI
Primary source
MGI:MGI:2146322
See related
Ensembl:ENSMUSG00000022419 Vega:OTTMUSG00000024429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Depdc6
Orthologs
Location:
15 D1; 15 21.96 cM
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 15 NC_000081.6 (55112317..55259273)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (54944038..55085757)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 2 Neighboring gene predicted gene, 41325 Neighboring gene DNA replication and sister chromatid cohesion 1 Neighboring gene predicted gene 9920 Neighboring gene predicted gene, 35312 Neighboring gene collagen, type XIV, alpha 1 Neighboring gene RNA binding motif protein, X-linked 2 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Markers

Homology

Clone Names

  • KIAA4200

Gene Ontology Provided by MGI

Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
intracellular ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
DEP domain-containing mTOR-interacting protein
Names
DEP domain-containing protein 6

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037937.3NP_001033026.1  DEP domain-containing mTOR-interacting protein isoform b

    See identical proteins and their annotated locations for NP_001033026.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AC124659, AK139888, AK220300
    Consensus CDS
    CCDS27475.1
    UniProtKB/Swiss-Prot
    Q570Y9
    UniProtKB/TrEMBL
    B2ZRS7
    Related
    ENSMUSP00000023056, OTTMUSP00000029175, ENSMUST00000023056, OTTMUST00000059893
    Conserved Domains (3) summary
    cd00992
    Location:327391
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04441
    Location:121205
    DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
    cl02442
    Location:29105
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
  2. NM_145470.3NP_663445.2  DEP domain-containing mTOR-interacting protein isoform a

    See identical proteins and their annotated locations for NP_663445.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC124659, AK220300, DV649395
    Consensus CDS
    CCDS27474.1
    UniProtKB/Swiss-Prot
    Q570Y9
    UniProtKB/TrEMBL
    B2ZRS3
    Related
    ENSMUSP00000094167, OTTMUSP00000029173, ENSMUST00000096433, OTTMUST00000059891
    Conserved Domains (3) summary
    cd00992
    Location:339403
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04441
    Location:133217
    DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
    cd04442
    Location:36117
    DEP_1_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p3 C57BL/6J

    Range
    55112317..55259273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000037.1 Alternate Mm_Celera

    Range
    56652739..56799891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)