IST1 increased sodium tolerance 1 homolog (yeast) [Homo sapiens] - Gene

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Summary

Official Symbol: IST1provided by HGNC
Official Full Name: increased sodium tolerance 1 homolog (yeast)provided by HGNC
Primary source: HGNC:28977
See related: Ensembl:ENSG00000182149; HPRD:13784; Vega:OTTHUMG00000137597
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KIAA0174

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Genomic context

Location :: 16q22.2

Sequence :: Chromosome: 16; NC_000016.9 (71929446..71962906)

See IST1 in Epigenomics, MapViewer

Chromosome 16 - NC_000016.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results demonstrate that cigarette smoke regulates OLC1 expression in lung cancer cells by compromising its ubiquitination and subsequent degradation through the ubiquitin E3 ligase APC.
Title: Cigarette smoke suppresses the ubiquitin-dependent degradation of OLC1.
These data suggest that Ist1 interaction is important for spartin recruitment to the midbody and that spartin participates in cytokinesis.
Title: SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis.
Results demonstrate that human calpain 7 is proteolytically active, and imply that calpain 7 is activated by ESCRT-III-related protein IST1.
Title: Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction.
Data show that the N-terminal core domains of increased sodium tolerance-1 (IST1) and charged multivesicular body protein-3 (CHMP3) form equivalent four-helix bundles, revealing that IST1 is a previously unrecognized ESCRT-III family member.
Title: Structural basis for ESCRT-III protein autoinhibition.
hIST1 is essential for cytokinesis in mammalian cells.
Title: Essential role of hIST1 in cytokinesis.
IST1 and CHMP1 act together to recruit and modulate specific VPS4 activities required during the final stages of cell division.
Title: Biochemical analyses of human IST1 and its function in cytokinesis.
OLC1 (KIAA0174) is a candidate oncogene in lung cancer whose expression may be regulated by exposure to cigarette smoke.
Title: Overexpression of OLC1, cigarette smoke, and human lung tumorigenesis.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.

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Products	Interactant	Other Gene	Source	Pubs	Description
P53990	P13798	APEH	HPRD	PubMed
P53990	P54253	ATXN1	HPRD	PubMed
BioGRID:115141	BioGRID:118937	ANAPC2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115141	BioGRID:106824	APEH	BioGRID	PubMed	Two-hybrid
BioGRID:115141	BioGRID:107427	CDC20	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115141	BioGRID:121394	CHMP1B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115141	BioGRID:119489	FZR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115141	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cell cycle	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasmic membrane-bounded vesicle	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum-Golgi intermediate compartment	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: IST1 homolog

Names: IST1 homolog; hIST1; increased sodium tolerance-1; putative MAPK-activating protein PM28

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014761.2 → NP_055576.2 IST1 homolog

Status: PROVISIONAL

Source sequence(s)

BC000430

Consensus CDS

CCDS10905.1

UniProtKB/Swiss-Prot

P53990

Related

ENSP00000330408, OTTHUMP00000174932, ENST00000329908, OTTHUMT00000269006

Conserved Domains (1) summary

pfam03398
Location:33 – 177
Blast Score: 550

Ist1; Regulator of Vps4 activity in the MVB pathway

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000016.9 Reference GRCh37.p5 Primary Assembly

Range

71929446..71962906

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000148.1 Alternate HuRef

Range

57697312..57730088

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC009127.10 (83381..116841)	None
genomic	CH471166.2	EAW59205.1
		EAW59206.1
		EAW59207.1
		EAW59208.1
		EAW59209.1
genomic	CQ834564.1	CAH05497.1
mRNA	AB097052.1	BAC77405.1
mRNA	AK057902.1	None
mRNA	AK291388.1	BAF84077.1
mRNA	AK293022.1	BAF85711.1
mRNA	AK293040.1	BAF85729.1
mRNA	AK295066.1	BAG58114.1
mRNA	AK297088.1	BAG59603.1
mRNA	AK297336.1	BAG59792.1
mRNA	AK301918.1	BAG63341.1
mRNA	AL355695.1	None
mRNA	BC000116.1	AAH00116.1
mRNA	BC000430.2	AAH00430.1
mRNA	BC004359.1	AAH04359.1
mRNA	BC103745.1	AAI03746.1
mRNA	D79996.1	BAA11491.2
other-genetic	HQ447682.1	ADQ32167.1