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ATG13 autophagy related 13 [ Homo sapiens (human) ]

Gene ID: 9776, updated on 6-Jul-2014
Official Symbol
ATG13provided by HGNC
Official Full Name
autophagy related 13provided by HGNC
Primary source
HGNC:29091
See related
Ensembl:ENSG00000175224; HPRD:13809; MIM:615088; Vega:OTTHUMG00000166538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA0652; PARATARG8
See ATG13 in Epigenomics, MapViewer
Location:
11p11.2
Exon count :
21
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (46617276..46676019)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (46638826..46697569)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene autophagy/beclin-1 regulator 1 Neighboring gene ribosomal protein S10 pseudogene 19 Neighboring gene microRNA 3160-1 Neighboring gene microRNA 3160-2 Neighboring gene harbinger transposase derived 1 Neighboring gene Rho GTPase activating protein 1 Neighboring gene zinc finger protein 408

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
autophagic vacuole assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
ULK1-ATG13-FIP200 complex IPI
Inferred from Physical Interaction
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
pre-autophagosomal structure ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
autophagy-related protein 13
Names
autophagy-related protein 13
ATG13 autophagy related 13 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142673.2NP_001136145.1  autophagy-related protein 13 isoform 1

    See proteins identical to NP_001136145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) includes an alternate exon in the 5' UTR and lacks an exon in the coding region compared to variant 3. The resulting protein (isoform 1) is shorter but has the same N- and C- termini compared to isoform 3. Variants 1 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC115088, AK289641, BC002378, CD675643, DA195671
    Consensus CDS
    CCDS44582.1
    UniProtKB/TrEMBL
    A8K0S6
    UniProtKB/Swiss-Prot
    O75143
    Conserved Domains (1) summary
    pfam10033
    Location:17195
    Blast Score: 344
    ATG13; Autophagy-related protein 13
  2. NM_001205119.1NP_001192048.1  autophagy-related protein 13 isoform 3

    See proteins identical to NP_001192048.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC115088, AK223603, BC002378, DA195671
    Consensus CDS
    CCDS55760.1
    UniProtKB/Swiss-Prot
    O75143
    Conserved Domains (1) summary
    pfam10033
    Location:17195
    Blast Score: 345
    ATG13; Autophagy-related protein 13
  3. NM_001205120.1NP_001192049.1  autophagy-related protein 13 isoform 1

    See proteins identical to NP_001192049.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the coding region compared to variant 3. The resulting protein (isoform 1) is shorter but has the same N- and C-termini compared to isoform 3. Variants 1 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AB014552, AC115088, DA195671
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    O75143
    Conserved Domains (1) summary
    pfam10033
    Location:17195
    Blast Score: 344
    ATG13; Autophagy-related protein 13
  4. NM_001205121.1NP_001192050.1  autophagy-related protein 13 isoform 2

    See proteins identical to NP_001192050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) includes an alternate exon in the 5' UTR and lacks two exons in the coding region compared to variant 3. The resulting protein (isoform 2) is shorter but has the same N- and C- termini compared to isoform 3. Variants 2 and 5 encode the same protein (isoform 2).
    Source sequence(s)
    AB014552, AC115088, AK023867, DA195671
    Consensus CDS
    CCDS7921.1
    UniProtKB/Swiss-Prot
    O75143
    Conserved Domains (1) summary
    pfam10033
    Location:17195
    Blast Score: 342
    ATG13; Autophagy-related protein 13
  5. NM_001205122.1NP_001192051.1  autophagy-related protein 13 isoform 4

    See proteins identical to NP_001192051.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences compared to variant 3. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 3. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 3.
    Source sequence(s)
    AB014552, AC115088, AK294110, DA195671
    Consensus CDS
    CCDS55761.1
    UniProtKB/Swiss-Prot
    O75143
    Conserved Domains (1) summary
    pfam10033
    Location:7116
    Blast Score: 192
    ATG13; Autophagy-related protein 13
  6. NM_014741.4NP_055556.2  autophagy-related protein 13 isoform 2

    See proteins identical to NP_055556.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 5' UTR and lacks two exons in the coding region compared to variant 3. The resulting protein (isoform 2) is shorter but has the same N- and C- termini compared to isoform 3. Variants 2 and 5 encode the same protein (isoform 2).
    Source sequence(s)
    AC115088, BC002378, DA195671
    Consensus CDS
    CCDS7921.1
    UniProtKB/Swiss-Prot
    O75143
    Conserved Domains (1) summary
    pfam10033
    Location:17195
    Blast Score: 342
    ATG13; Autophagy-related protein 13

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    46617276..46676019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253265.1XP_005253322.1  

    See proteins identical to XP_005253322.1

    UniProtKB/Swiss-Prot
    O75143
    Conserved Domains (1) summary
    pfam10033
    Location:17195
    Blast Score: 345
    ATG13; Autophagy-related protein 13
  2. XM_006718396.1XP_006718459.1  

    See proteins identical to XP_006718459.1

    UniProtKB/Swiss-Prot
    O75143
    Conserved Domains (1) summary
    pfam10033
    Location:17195
    Blast Score: 345
    ATG13; Autophagy-related protein 13
  3. XM_006718394.1XP_006718457.1  

    See proteins identical to XP_006718457.1

    UniProtKB/Swiss-Prot
    O75143
    Conserved Domains (1) summary
    pfam10033
    Location:17195
    Blast Score: 345
    ATG13; Autophagy-related protein 13
  4. XM_005253263.1XP_005253320.1  

    See proteins identical to XP_005253320.1

    UniProtKB/Swiss-Prot
    O75143
    Related
    ENSP00000431974, OTTHUMP00000233323, ENST00000526508, OTTHUMT00000390297
    Conserved Domains (1) summary
    pfam10033
    Location:17195
    Blast Score: 345
    ATG13; Autophagy-related protein 13
  5. XM_006718395.1XP_006718458.1  

    See proteins identical to XP_006718458.1

    UniProtKB/Swiss-Prot
    O75143
    Conserved Domains (1) summary
    pfam10033
    Location:17195
    Blast Score: 345
    ATG13; Autophagy-related protein 13
  6. XM_005253266.1XP_005253323.1  

    See proteins identical to XP_005253323.1

    UniProtKB/Swiss-Prot
    O75143
    Related
    ENSP00000352500, OTTHUMP00000233325, ENST00000359513, OTTHUMT00000390300
    Conserved Domains (1) summary
    pfam10033
    Location:17195
    Blast Score: 345
    ATG13; Autophagy-related protein 13
  7. XM_005253262.1XP_005253319.1  

    See proteins identical to XP_005253319.1

    UniProtKB/Swiss-Prot
    O75143
    Related
    ENSP00000310321, ENST00000312040
    Conserved Domains (1) summary
    pfam10033
    Location:17195
    Blast Score: 345
    ATG13; Autophagy-related protein 13
  8. XM_005253268.1XP_005253325.1  

    See proteins identical to XP_005253325.1

    UniProtKB/Swiss-Prot
    O75143
    Conserved Domains (1) summary
    pfam10033
    Location:17195
    Blast Score: 345
    ATG13; Autophagy-related protein 13

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    46345178..46403609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    46637238..46695980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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