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ADGRE5 adhesion G protein-coupled receptor E5 [ Homo sapiens (human) ]

Gene ID: 976, updated on 8-May-2016
Official Symbol
ADGRE5provided by HGNC
Official Full Name
adhesion G protein-coupled receptor E5provided by HGNC
Primary source
HGNC:HGNC:1711
See related
Ensembl:ENSG00000123146 HPRD:03130; MIM:601211; Vega:OTTHUMG00000182166
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD97; TM7LN1
Summary
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]
Orthologs
Location:
19p13.12
Exon count:
20
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (14381144..14408725)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14491403..14519537)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372288 Neighboring gene uncharacterized LOC101928845 Neighboring gene DEAD-box helicase 39A Neighboring gene protein kinase N1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of CD97 molecule by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
movement of cell or subcellular component TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
CD97 antigen
Names
CD97 molecule
leukocyte antigen CD97
seven transmembrane helix receptor
seven-span transmembrane protein
seven-transmembrane, heterodimeric receptor associated with inflammation

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029253.1 RefSeqGene

    Range
    5001..32582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025160.2NP_001020331.1  CD97 antigen isoform 3 preproprotein

    See identical proteins and their annotated locations for NP_001020331.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (3, also known as CD97(EGF 1,2,3,5)) is shorter than isoform 1.
    Source sequence(s)
    AI890331, AK225655, AK292159, DC381605, DC414739
    Consensus CDS
    CCDS32930.1
    UniProtKB/Swiss-Prot
    P48960
    Related
    ENSP00000349918, OTTHUMP00000268562, ENST00000357355, OTTHUMT00000459819
    Conserved Domains (3) summary
    cd00054
    Location:160196
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00002
    Location:495733
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:443488
    GPS; Latrophilin/CL-1-like GPS domain
  2. NM_001784.4NP_001775.2  CD97 antigen isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001775.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2, also known as CD97(EGF 1,2,5)) is shorter than isoform 1.
    Source sequence(s)
    AI890331, AK292159, BC026690, DC414739
    Consensus CDS
    CCDS32931.1
    UniProtKB/Swiss-Prot
    P48960
    Related
    ENSP00000351413, OTTHUMP00000268561, ENST00000358600, OTTHUMT00000459817
    Conserved Domains (3) summary
    cd00054
    Location:116152
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00002
    Location:451689
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:399444
    GPS; Latrophilin/CL-1-like GPS domain
  3. NM_078481.3NP_510966.1  CD97 antigen isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_510966.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as CD97(EGF 1,2,3,4,5)).
    Source sequence(s)
    AI890331, AK314697, DC381605, DC414739, U76764
    Consensus CDS
    CCDS32929.1
    UniProtKB/Swiss-Prot
    P48960
    Related
    ENSP00000242786, OTTHUMP00000268563, ENST00000242786, OTTHUMT00000459821
    Conserved Domains (3) summary
    cd00054
    Location:209245
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00002
    Location:544782
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:492537
    GPS; Latrophilin/CL-1-like GPS domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    14381144..14408725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528451.1XP_011526753.1  

    Conserved Domains (3) summary
    cd00054
    Location:209245
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00002
    Location:544782
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:492537
    GPS; Latrophilin/CL-1-like GPS domain

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    14492109..14519545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)