HDAC4 histone deacetylase 4 [ Homo sapiens ]

Gene ID: 9759, updated on 12-May-2012

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Summary

Official Symbol: HDAC4provided by HGNC
Official Full Name: histone deacetylase 4provided by HGNC
Primary source: HGNC:14063
See related: Ensembl:ENSG00000068024; HPRD:05610; MIM:605314; Vega:OTTHUMG00000133344
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; KIAA0288
Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 2q37.3

Sequence :: Chromosome: 2; NC_000002.11 (239969864..240322643, complement)

See HDAC4 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HDAC4/Sp1/miR-200a regulatory network induces the down-regulation of miR-200a and the up-regulation of HDAC4 in hepatocellular carcinoma.
Title: The histone deacetylase 4/SP1/microrna-200a regulatory network contributes to aberrant histone acetylation in hepatocellular carcinoma.
HDAC4 protein regulates HIF1alpha protein lysine acetylation and cancer cell response to hypoxia
Title: HDAC4 protein regulates HIF1α protein lysine acetylation and cancer cell response to hypoxia.
Deletion of hda4, a homolog of HDAC4, enhances learning and long-term memory in a thermotaxis model using Caenorhabditis elegans.
Title: Intracellular trafficking of histone deacetylase 4 regulates long-term memory formation.
The novel mechanism of action for HDAC4, suggesting it can function to dynamically regulate gene expression through changes in chromatin-nucleoporin association.
Title: Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins.
HDAC4 regulates random cell motility
Title: Ubiquitin-dependent degradation of HDAC4, a new regulator of random cell motility.
The authors observed that HDAC4 associates with HIV-1 viral DNA in a viral integrase-dependent manner.
Title: A role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectors.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Haploinsufficiency of HDAC4 results in brachydactyly mental retardation syndrome.
Title: Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems.
The results suggest that HDAC4 genes might play a role in the pathophysiology of schizophrenia in a Korean population.
Title: Association of histone deacetylase genes with schizophrenia in Korean population.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Association of histone deacetylase genes with schizophrenia in Korean population.

Submit: New GeneRIF Correction See all (51)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Brachydacytly-mental retardation syndrome

MIM: 600430

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_006028.1	NP_006657.1	RUVBL2	BIND	PubMed	RUVBL2 (reptin) interacts with HDAC4.
NP_006028.1	NC_000003.9	TNFSF10	BIND	PubMed	HDAC4 interacts with the TNFSF10 promoter.
P56524	Q9H9E1	ANKRA2	HPRD	PubMed
P56524	Q6UB99	ANKRD11	HPRD	PubMed
P56524	P46100	ATRX	HPRD	PubMed
P56524	P41182	BCL6	HPRD	PubMed
P56524	Q6W2J9	BCOR	HPRD	PubMed
P56524	Q9HCU9	BRMS1	HPRD	PubMed
P56524	Q16566	CAMK4	HPRD	PubMed
P56524	P45973	CBX5	HPRD	PubMed
P56524	P33076	CIITA	HPRD	PubMed
P56524	Q9NP62	GCM1	HPRD	PubMed
P56524	O15379	HDAC3	HPRD	PubMed
P56524	P56524	HDAC4	HPRD	PubMed
P56524	Q9UKV0	HDAC9	HPRD	PubMed
P56524	BPY2 interacting protein 1	MAP1S	HPRD	PubMed
P56524	P28482	MAPK1	HPRD	PubMed
P56524	P27361	MAPK3	HPRD	PubMed
P56524	Q03112	MECOM	HPRD	PubMed
P56524	Q02078	MEF2A	HPRD	PubMed
P56524	Q06413	MEF2C	HPRD	PubMed
P56524	Q14814	MEF2D	HPRD	PubMed
P56524	MEGF10 protein	MEGF10	HPRD	PubMed
P56524	Q96RE7	NACC1	HPRD	PubMed
P56524	Q9Y618	NCOR2	HPRD	PubMed
P56524	Q00653	NFKB2	HPRD	PubMed
P56524	P13056	NR2C1	HPRD	PubMed
P56524	P49792	RANBP2	HPRD	PubMed
P56524	Q09028	RBBP4	HPRD	PubMed
P56524	O14593	RFXANK	HPRD	PubMed
P56524	Q13950	RUNX2	HPRD	PubMed
P56524	Q13761	RUNX3	HPRD	PubMed
P56524	Q9Y230	RUVBL2	HPRD	PubMed
P56524	P63165	SUMO1	HPRD	PubMed
P56524	P61956	SUMO2	HPRD	PubMed
P56524	Q92956	TNFRSF14	HPRD	PubMed
P56524	P62258	YWHAE	HPRD	PubMed
P56524	P61981	YWHAG	HPRD	PubMed
P56524	P63104	YWHAZ	HPRD	PubMed
P56524	Q05516	ZBTB16	HPRD	PubMed
BioGRID:115106	BioGRID:106573	ACTA1	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:121558	AHRR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:121758	ANKRA2	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:115106	BioGRID:106862	AR	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:115106	BioGRID:107776	ATF2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:107028	ATRX	BioGRID	PubMed	Two-hybrid
BioGRID:115106	BioGRID:112217	ATXN1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:107076	BCL6	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:115106	BioGRID:120228	BCOR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:121961	BCORL1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:107229	CACNA1C	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:114106	CAMK1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:107267	CAMK2D	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:115106	BioGRID:107264	CAMK4	BioGRID	PubMed	Biochemical Activity
BioGRID:115106	BioGRID:117030	CBX5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115106	BioGRID:107455	CDK5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:107460	CDKN1A	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:107481	CEBPD	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:110416	CIITA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:113736	CSRP3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115106	BioGRID:107869	CTBP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:107880	CTNNB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:198961	Ctbp1	BioGRID	PubMed	Two-hybrid
BioGRID:115106	BioGRID:117350	DNAJB5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:115360	DNAJB6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:127919	DNAJB8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:127605	ESCO2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:115106	BioGRID:119170	FOXP3	BioGRID	PubMed	Co-localization
BioGRID:115106	BioGRID:108893	GATA1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115106	BioGRID:108895	GATA3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:114093	GCM1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:109044	GNB1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115106	BioGRID:114368	HDAC3	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:115106	BioGRID:115106	HDAC4	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115106	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:119613	HDAC7	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:115083	HDAC9	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:109337	HIC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:109338	HIF1A	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115106	BioGRID:109414	HNF4A	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:109697	IFRD1	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:115604	IKZF1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:116485	IKZF2	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:116484	IKZF3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:122146	IKZF4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:124093	LCOR	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:113852	LZTR1	BioGRID	PubMed	Two-hybrid
BioGRID:115106	BioGRID:120498	MAP1S	BioGRID	PubMed	Two-hybrid
BioGRID:115106	BioGRID:111580	MAPK1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:115106	BioGRID:111581	MAPK3	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:115106	BioGRID:110310	MARK3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:108423	MECOM	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:110369	MEF2A	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115106	BioGRID:110372	MEF2C	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:115106	BioGRID:110373	MEF2D	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:116547	MORC2	BioGRID	PubMed	Co-localization
BioGRID:115106	BioGRID:114973	NCOR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:115106	BioGRID:114974	NCOR2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115106	BioGRID:110857	NFKB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:110859	NFKBIA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:110861	NFKBIE	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:110939	NPPB	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:113222	NR1H2	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:115106	BioGRID:113033	NR2C1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115106	BioGRID:113034	NR2C2	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:114990	NUP155	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:115106	BioGRID:113717	NUP214	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:203350	Ncor2	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:111105	PARK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:111463	PPARD	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:111464	PPARG	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:111507	PPP2CA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:111516	PPP2R4	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:111839	RANBP2	BioGRID	PubMed	Biochemical Activity
BioGRID:115106	BioGRID:111849	RARA	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:111863	RBBP4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:111910	REST	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:111912	REV3L	BioGRID	PubMed	Two-hybrid
BioGRID:115106	BioGRID:111925	RFX5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:114180	RFXANK	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115106	BioGRID:111926	RFXAP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:971427	RL2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115106	BioGRID:107308	RUNX2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:112168	RXRA	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:118930	SENP1	BioGRID	PubMed	Co-localization
BioGRID:115106	BioGRID:113368	SF1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:109072	SFN	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115106	BioGRID:117439	SIN3A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:116983	SIRT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:110263	SMAD3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115106	BioGRID:112550	SP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:112600	SRF	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115106	BioGRID:117505	SS18L1	BioGRID	PubMed	Two-hybrid
BioGRID:115106	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:112706	SUV39H1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:112717	SYK	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:113011	TP53BP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:204385	Twist1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:113177	UBE2I	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Two-hybrid
BioGRID:115106	BioGRID:113361	YWHAB	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:113363	YWHAE	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:115106	BioGRID:113364	YWHAG	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:115106	BioGRID:116168	YWHAQ	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
BioGRID:115106	BioGRID:113366	YWHAZ	BioGRID	PubMed	Reconstituted Complex
BioGRID:115106	BioGRID:113360	YY1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115106	BioGRID:113498	ZBTB16	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115106	BioGRID:112800	ZNF354A	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
NAD-dependent histone deacetylase activity (H3-K14 specific)	IEA Inferred from Electronic Annotation more info
NAD-dependent histone deacetylase activity (H3-K9 specific)	IEA Inferred from Electronic Annotation more info
NAD-dependent histone deacetylase activity (H4-K16 specific)	IEA Inferred from Electronic Annotation more info
activating transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
histone deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
histone deacetylase activity	IEA Inferred from Electronic Annotation more info
histone deacetylase activity (H3-K16 specific)	IEA Inferred from Electronic Annotation more info
histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
hydrolase activity	IEA Inferred from Electronic Annotation more info
potassium ion binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase binding	IEA Inferred from Electronic Annotation more info
repressing transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
B cell activation	TAS Traceable Author Statement more info	PubMed
B cell differentiation	TAS Traceable Author Statement more info	PubMed
cardiac muscle hypertrophy in response to stress	TAS Traceable Author Statement more info	PubMed
chromatin modification	IEA Inferred from Electronic Annotation more info
chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
histone H3 deacetylation	IDA Inferred from Direct Assay more info	PubMed
histone H4 deacetylation	IDA Inferred from Direct Assay more info	PubMed
histone deacetylation	IDA Inferred from Direct Assay more info	PubMed
histone deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
inflammatory response	TAS Traceable Author Statement more info	PubMed
negative regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of glycolysis	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of myotube differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of sequence-specific DNA binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
nervous system development	TAS Traceable Author Statement more info	PubMed
osteoblast development	IEA Inferred from Electronic Annotation more info
peptidyl-lysine deacetylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of sequence-specific DNA binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of transcription, DNA-dependent	ISS Inferred from Sequence or Structural Similarity more info
regulation of cardiac muscle contraction by calcium ion signaling	IEA Inferred from Electronic Annotation more info
regulation of protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of skeletal muscle fiber development	IEA Inferred from Electronic Annotation more info
response to denervation involved in regulation of muscle adaptation	ISS Inferred from Sequence or Structural Similarity more info
response to interleukin-1	IMP Inferred from Mutant Phenotype more info	PubMed
skeletal system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
actomyosin	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	IEA Inferred from Electronic Annotation more info
histone deacetylase complex	IDA Inferred from Direct Assay more info	PubMed
histone deacetylase complex	IEA Inferred from Electronic Annotation more info
neuromuscular junction	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
transcriptional repressor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: histone deacetylase 4

Names: histone deacetylase 4; histone deacetylase A

NP_006028.2

EC 3.5.1.98

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009235.1 RefSeqGene

Range

5001..357780

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_006037.3 → NP_006028.2 histone deacetylase 4

Status: REVIEWED

Source sequence(s)

AB006626, AI199675, AI654062, BC039904, BQ576173

Consensus CDS

CCDS2529.1

UniProtKB/Swiss-Prot

P56524

UniProtKB/TrEMBL

Q86YH7

Related

ENSP00000264606, OTTHUMP00000164483, ENST00000345617, OTTHUMT00000257174

Conserved Domains (3) summary

COG0123
Location:654 – 1002
Blast Score: 610

AcuC; Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]

cd10162
Location:90 – 148
Blast Score: 267

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cl02986
Location:669 – 993
Blast Score: 925

Hist_deacetyl; Histone deacetylase domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

239969864..240322643, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

231741321..232068649, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC017028.11	AAX93070.1
genomic	AC062017.6	AAX93254.1
genomic	CH471063.1	EAW71165.1
		EAW71166.1
mRNA	AB006626.2	BAA22957.2
mRNA	AF070607.1	None
mRNA	AF132607.1	AAD29046.1
mRNA	AI199675.1	None
mRNA	AI654062.1	None
mRNA	AK302719.1	BAH13789.1
mRNA	AK303368.1	BAH13951.1
mRNA	AK303467.1	BAH13968.1
mRNA	AK303617.1	BAH13999.1
mRNA	AK308791.1	None
mRNA	AK310488.1	None
mRNA	AK310603.1	None
mRNA	AK311582.1	None
mRNA	BC039904.1	AAH39904.1
mRNA	BQ576173.1	None

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P56524.3	GenPept	UniProtKB/Swiss-Prot:P56524
Q53SB4	GenPept	UniProtKB/TrEMBL:Q53SB4
Q53SM2	GenPept	UniProtKB/TrEMBL:Q53SM2
Q86YH7	GenPept	UniProtKB/TrEMBL:Q86YH7