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    SLK STE20-like kinase [ Homo sapiens ]

    Gene ID: 9748, updated on 11-May-2012
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    Summary

    Official Symbol
    SLKprovided by HGNC
    Official Full Name
    STE20-like kinaseprovided by HGNC
    Primary source
    HGNC:11088
    See related
    Ensembl:ENSG00000065613; HPRD:11585; Vega:OTTHUMG00000018999
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LOSK; STK2; se20-9; bA16H23.1; KIAA0204; MGC133067
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    Genomic context

    Location :
    10q24.33
    Sequence :
    Chromosome: 10; NC_000010.10 (105727470..105787342)
    See SLK in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene SH3 and PX domains 2A Neighboring gene uncharacterized LOC100505839 Neighboring gene oligonucleotide/oligosaccharide-binding fold containing 1 Neighboring gene collagen, type XVII, alpha 1 Neighboring gene microRNA 936 Neighboring gene SWI5-dependent recombination repair 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids. Cha PC, et al. Nat Genet, 2011 May. PMID 21460842.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
    5. The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility. Roovers K, et al. Oncogene, 2009 Aug 6. PMID 19525980.

    See all (24) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    2. Studies define an interaction between Neu and SLK signaling in the regulation of cancer cell motility.
      Title: The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility.
    3. Protein kinase LOSK is required for radial microtubule organization and for the proper localization of Golgi complex in various cell types.
      Title: Ste20-related protein kinase LOSK (SLK) controls microtubule radial array in interphase.
    4. we show that a novel isoform of SPS1-related proline alanine-rich kinase (SPAK/STE20) is involved in this inflammatory signaling cascade
      Title: Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform.
    5. v-Src-dependent down-regulation of the Ste20-like kinase SLK through casein kinase II.
      Title: v-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9H2G2 P42574 CASP3    HPRD  PubMed  
    Q9H2G2 O94985 CLSTN1    HPRD  PubMed  
    BioGRID:115096 BioGRID:116550 CLSTN1    BioGRID  PubMed Two-hybrid 
    BioGRID:115096 BioGRID:115156 KEAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115096 BioGRID:111200 PDZK1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:115096 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the SLK gene: The SLK gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and C.elegans.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    STE20-like serine/threonine-protein kinase
    Names
    STE20-like serine/threonine-protein kinase
    hSLK
    STE20-related kinase
    Long Ste20-like Kinase
    CTCL tumor antigen se20-9
    serine/threonine-protein kinase 2
    Ste20-related serine/threonine kinase
    SNF1 sucrose nonfermenting like kinase
    STE20-related serine/threonine-protein kinase
    SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase
    NP_055535.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014720.2 → NP_055535.2  STE20-like serine/threonine-protein kinase

      Status: PROVISIONAL

      Source sequence(s)
      AF273048
      Consensus CDS
      CCDS7553.1
      UniProtKB/Swiss-Prot
      Q9H2G2
      Related
      ENSP00000358770, OTTHUMP00000020426, ENST00000369755, OTTHUMT00000050188
      Conserved Domains (3) summary
      cd06643
      Location:28 – 304
      Blast Score: 1447
      STKc_SLK; Catalytic domain of the Protein Serine/Threonine Kinase, Ste20-like kinase
      smart00220
      Location:34 – 292
      Blast Score: 785
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:1029 – 1160
      Blast Score: 335
      PKK; Polo kinase kinase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      105727470..105787342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      99381490..99418394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL138761.12 CAI12395.1
      CAI12396.1
    genomic AL360170.23 CAH70403.1
      CAH70404.1
    genomic CH471066.2 EAW49615.1
      EAW49616.1
      EAW49617.1
      EAW49618.1
    genomic FB775502.1 CAV30708.1
    mRNA AB002804.1 BAA19655.1
    mRNA AF273048.1 AAG34908.1
    mRNA AK302855.1 BAG64041.1
    mRNA AK307389.1 None
    mRNA BC008697.1 None
    mRNA BC036736.1 None
    mRNA BC047762.1 AAH47762.1
    mRNA BC047885.1 AAH47885.1
    mRNA BC064804.1 AAH64804.1
    mRNA BC111565.1 AAI11566.1
    mRNA D86959.1 BAA13195.2
    mRNA EF139853.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H2G2.1 GenPept UniProtKB/Swiss-Prot:Q9H2G2
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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