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ARHGAP32 Rho GTPase activating protein 32 [ Homo sapiens (human) ]

Gene ID: 9743, updated on 13-Jan-2015
Official Symbol
ARHGAP32provided by HGNC
Official Full Name
Rho GTPase activating protein 32provided by HGNC
Primary source
HGNC:HGNC:17399
See related
Ensembl:ENSG00000134909; HPRD:12257; MIM:608541; Vega:OTTHUMG00000165774
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRIT; RICS; GC-GAP; PX-RICS; p250GAP; p200RhoGAP
Summary
RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]
Orthologs
See ARHGAP32 in MapViewer
Location:
11q24.3
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (128965060..129192198, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (128834955..129062093, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 45 Neighboring gene potassium channel, inwardly rectifying subfamily J, member 5 Neighboring gene tumor protein p53 regulated apoptosis inducing protein 1 Neighboring gene zinc finger protein 123, pseudogene Neighboring gene BARX homeobox 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of Rho GTPase activating protein 32 (ARHGAP32; RICS) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC1892, KIAA0712

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
rho GTPase-activating protein 32
Names
rho GTPase-activating protein 32
GAB-associated CDC42
rac GTPase activating protein
rho-type GTPase-activating protein 32
GTPase regulator interacting with TrkA
GTPase-activating protein for Cdc42 and Rac1
brain-specific Rho GTPase-activating protein
rho/Cdc42/Rac GTPase-activating protein RICS
brain-specific Rho GTP-ase-activating protein
GAB-associated Cdc42/Rac GTPase-activating protein
RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signaling
rhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142685.1NP_001136157.1  rho GTPase-activating protein 32 isoform 1

    See proteins identical to NP_001136157.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This isoform is also known as PX-RICS.
    Source sequence(s)
    AL833062, AP000751, CK823137, EF127492
    Consensus CDS
    CCDS44769.1
    UniProtKB/Swiss-Prot
    A7KAX9
    UniProtKB/TrEMBL
    Q86T64
    Related
    ENSP00000310561, OTTHUMP00000230948, ENST00000310343, OTTHUMT00000386151
    Conserved Domains (3) summary
    cd07298
    Location:127241
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:263316
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:368562
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
  2. NM_014715.3NP_055530.2  rho GTPase-activating protein 32 isoform 2

    See proteins identical to NP_055530.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple exons in the 5' UTR and 5' coding region and has a unique exon for its 5' UTR, compared to variant 1. These differences cause translation initiation from a downstream in-frame start codon. The encoded protein (isoform 2) has a shorter N-terminus which lacks phox homology and src homology 3 domains, compared to isoform 1.
    Source sequence(s)
    AB079856, AP000751, BQ319051, EF127492
    Consensus CDS
    CCDS31718.1
    UniProtKB/Swiss-Prot
    A7KAX9
    Conserved Domains (1) summary
    cd04384
    Location:19213
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    128965060..129192198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271736.2XP_005271793.1  

    See proteins identical to XP_005271793.1

    Conserved Domains (3) summary
    cd07298
    Location:101215
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:237290
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:342536
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
  2. XM_006718947.1XP_006719010.1  

    Conserved Domains (1) summary
    pfam11725
    Location:460683
    AvrE; Pathogenicity factor

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    128721150..128948156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    124785776..125014078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)