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    CD79B CD79b molecule, immunoglobulin-associated beta [ Homo sapiens ]

    Gene ID: 974, updated on 11-May-2012
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    Summary

    Official Symbol
    CD79Bprovided by HGNC
    Official Full Name
    CD79b molecule, immunoglobulin-associated betaprovided by HGNC
    Primary source
    HGNC:1699
    See related
    Ensembl:ENSG00000007312; HPRD:00922; MIM:147245; Vega:OTTHUMG00000172294
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B29; IGB; AGM6
    Summary
    The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    17q23
    Sequence :
    Chromosome: 17; NC_000017.10 (62006098..62009704, complement)
    See CD79B in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene chorionic somatomammotropin hormone-like 1 Neighboring gene growth hormone 1 Neighboring gene sodium channel, voltage-gated, type IV, alpha subunit Neighboring gene chromosome 17 open reading frame 72 Neighboring gene intercellular adhesion molecule 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Downregulation of the B-cell receptor signaling component CD79b in plasma cell myeloma: a possible post transcriptional regulation. Huang X, et al. Pathol Int, 2011 Mar. PMID 21355953.
    3. Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas. Naylor TL, et al. Cancer Res, 2011 Apr 1. PMID 21324920.
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086.
    5. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. Lee KM, et al. Am J Hematol, 2010 Aug. PMID 20568250.

    See all (54) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. STN produced significant antitumor effects in a mouse xenograft model of CD79A/B-mutated DLBCL.
      Title: Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas.
    2. Expression of CD79b is downregulated in both plasma cells and plasma cell myeloma.
      Title: Downregulation of the B-cell receptor signaling component CD79b in plasma cell myeloma: a possible post transcriptional regulation.
    3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
    5. mutations responsible for agammaglobulinemia in humans
      Title: Ig beta deficiency in humans.
    6. Ig-beta was phosphorylated in about 20% of myeloma IgG BCR isolates, but not in normal B-cell controls.
      Title: Signaling status of IgG B cell receptor (IgG BCR) is indicative for an activated state of circulating B cells in multiple myeloma.
    7. Anti-CD79b antibodies downregulated surface B-cell receptor and were trafficked to the lysosomal-like major histocompatibility complex class II-positive compartment of a mouse xenograft model of non-Hodgkin lymphoma.
      Title: Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma.
    8. These results indicate that mutations in Igbeta can cause agammaglobulinemia in man.
      Title: Mutations of the Igbeta gene cause agammaglobulinemia in man.
    9. establish a strong linkage between Igbeta mRNA expression and somatic hypermutation in chronic lymphocytic leukaemia and highlight the complex relationships between biochemical parameters and clinical status in this disease
      Title: Igbeta(CD79b) mRNA expression in chronic lymphocytic leukaemia cells correlates with immunoglobulin heavy chain gene mutational status but does not serve as an independent predictor of clinical severity.
    10. Following B cell receptor cross-linking, a significant amount of the transgenic Ig beta pool (together with Ig alpha) remains on the B cell surface independent of surface immunoglobulin internalization.
      Title: Ig-independent Ig beta expression on the surface of B lymphocytes after B cell receptor aggregation.
    Submit: New GeneRIF Correction See all (14)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Agammaglobulinemia 6

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates CD79B from the surface of dual-positive CD79b/CD20 B cells PubMed
    env SDF-1alpha reverses gp120-induced downregulation of CD79b in CD40- and IL-4-activated purified HIV-1 seronegative human peripheral blood B cells PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P40259 P51451 BLK    HPRD  PubMed  
    P40259 P15391 CD19    HPRD  PubMed  
    P40259 P07766 CD3E    HPRD  PubMed  
    P40259 P06127 CD5    HPRD  PubMed  
    P40259 P11912 CD79A    HPRD  PubMed  
    P40259 P06241 FYN    HPRD  PubMed  
    P40259 P06239 LCK    HPRD  PubMed  
    P40259 P07948 LYN    HPRD  PubMed  
    P40259 Q05397 PTK2    HPRD  PubMed  
    P40259 P29350 PTPN6    HPRD  PubMed  
    P40259 P43405 SYK    HPRD  PubMed  
    P40259 P43403 ZAP70    HPRD  PubMed  
    BioGRID:107412 BioGRID:107109 BLK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107412 BioGRID:107368 CD19    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107412 BioGRID:107411 CD79A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107412 BioGRID:111752 PTPRC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107412 BioGRID:113722 STAM    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107412 BioGRID:112717 SYK    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107412 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem (from REACTOME)
      Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, Fu et al. 1975, Kunkel e...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • B cell receptor signaling pathway, conserved biosystem (from KEGG)
      B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • BCR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      BCR signaling pathway, organism-specific biosystem
      BCR signaling pathway
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    B-cell antigen receptor complex-associated protein beta chain
    Names
    B-cell antigen receptor complex-associated protein beta chain
    Ig-beta
    B-cell-specific glycoprotein B29
    immunoglobulin-associated B29 protein
    CD79b antigen (immunoglobulin-associated beta)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007368.1 RefSeqGene

      Range
      5001..8607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_43

    mRNA and Protein(s)

    1. NM_000626.2 → NP_000617.1  B-cell antigen receptor complex-associated protein beta chain isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. The encoded isoform (1) is shorter compared to isoform 3, but has identical N- and C- termini.
      Source sequence(s)
      AC127029, AK222954, M89957
      Consensus CDS
      CCDS11655.1
      UniProtKB/Swiss-Prot
      P40259
      Related
      ENSP00000006750, OTTHUMP00000248034, ENST00000006750, OTTHUMT00000417711
      Conserved Domains (2) summary
      pfam07686
      Location:43 – 142
      Blast Score: 154
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:55 – 142
      Blast Score: 112
      Ig; Immunoglobulin domain

    2. NM_001039933.1 → NP_001035022.1  B-cell antigen receptor complex-associated protein beta chain isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AK222954, M89957
      Consensus CDS
      CCDS42372.1
      UniProtKB/Swiss-Prot
      P40259
      Related
      ENSP00000376544, OTTHUMP00000248033, ENST00000392795, OTTHUMT00000417710
      Conserved Domains (2) summary
      pfam07686
      Location:44 – 143
      Blast Score: 155
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:56 – 143
      Blast Score: 112
      Ig; Immunoglobulin domain

    3. NM_021602.2 → NP_067613.1  B-cell antigen receptor complex-associated protein beta chain isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site and also lacks an exon in the coding region, compared to variant 3. The encoded isoform (2) is shorter compared to isoform 3, but has identical N- and C- termini.
      Source sequence(s)
      AK222954, M89957, X83539
      Consensus CDS
      CCDS11656.1
      UniProtKB/Swiss-Prot
      P40259
      Related
      ENSP00000245862, OTTHUMP00000248035, ENST00000349817, OTTHUMT00000417713
      Conserved Domains (1) summary
      smart00077
      Location:89 – 108
      Blast Score: 73
      ITAM; Immunoreceptor tyrosine-based activation motif

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      62006098..62009704, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      57373817..57377419, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC127029.12 (37867..41481) None
    genomic CH471109.2 EAW94227.1
      EAW94228.1
      EAW94229.1
      EAW94230.1
      EAW94231.1
      EAW94232.1
    genomic JA738625.1 CCF76965.1
    genomic JA738627.1 CCF76966.1
    genomic JA738629.1 CCF76967.1
    genomic L27587.1 AAA72424.1
    genomic U22954.1 AAA98831.1
    genomic X83538.1 None
    mRNA AK222954.1 BAD96674.1
    mRNA AK223210.1 BAD96930.1
    mRNA AK313583.1 BAG36353.1
    mRNA AX775815.1 CAE11607.1
    mRNA AX775817.1 CAE11608.1
    mRNA BC002975.1 AAH02975.2
    mRNA BC030210.1 AAH30210.1
    mRNA BC032651.1 AAH32651.1
    mRNA M80461.1 AAA58387.1
    mRNA M89957.1 AAA64459.1
    mRNA S52229.1 AAB24822.2
    mRNA S79249.1 AAC60654.1
    mRNA X83539.1 CAA58522.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40259.1 GenPept UniProtKB/Swiss-Prot:P40259
    Q6PIS4 GenPept UniProtKB/TrEMBL:Q6PIS4
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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