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SETD1A SET domain containing 1A [ Homo sapiens (human) ]

Gene ID: 9739, updated on 12-May-2016
Official Symbol
SETD1Aprovided by HGNC
Official Full Name
SET domain containing 1Aprovided by HGNC
Primary source
HGNC:HGNC:29010
See related
Ensembl:ENSG00000099381 HPRD:13795; MIM:611052; Vega:OTTHUMG00000150474
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Set1; KMT2F; Set1A
Summary
The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. [provided by RefSeq, Jan 2015]
Orthologs
Location:
16p11.2
Exon count:
24
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (30948505..30984664)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30968615..30995985)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene cardiotrophin 2, pseudogene Neighboring gene FBXL19 antisense RNA 1 (head to head) Neighboring gene F-box and leucine-rich repeat protein 19 Neighboring gene ORAI calcium release-activated calcium modulator 3 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Neighboring gene syntaxin 1B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat Three components (Setd1A, CXXC1, WDR5) of the Set1 histone methyltransferase complex are identified to interact with HIV-1 Tat in Jurkat cell PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0339

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
histone methyltransferase activity (H3-K4 specific) IDA
Inferred from Direct Assay
more info
PubMed 
histone-lysine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
histone H3-K4 methylation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Set1C/COMPASS complex IDA
Inferred from Direct Assay
more info
PubMed 
chromosome IEA
Inferred from Electronic Annotation
more info
 
histone methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Preferred Names
histone-lysine N-methyltransferase SETD1A
Names
SET domain-containing protein 1A
hSET1A
lysine N-methyltransferase 2F
set1/Ash2 histone methyltransferase complex subunit SET1
NP_055527.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014712.2NP_055527.1  histone-lysine N-methyltransferase SETD1A

    See identical proteins and their annotated locations for NP_055527.1

    Status: VALIDATED

    Source sequence(s)
    AB002337, BC027450
    Consensus CDS
    CCDS32435.1
    UniProtKB/Swiss-Prot
    O15047
    Related
    ENSP00000262519, OTTHUMP00000197439, ENST00000262519, OTTHUMT00000318244
    Conserved Domains (6) summary
    smart00317
    Location:15681691
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00360
    Location:101166
    RRM; RNA recognition motif
    smart00508
    Location:16911707
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:14711707
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd12548
    Location:92186
    RRM_Set1A; RNA recognition motif in vertebrate histone-lysine N-methyltransferase Setd1A (Set1A)
    pfam11764
    Location:14181558
    N-SET; COMPASS (Complex proteins associated with Set1p) component N

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    30948505..30984664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545995.1XP_011544297.1  

    See identical proteins and their annotated locations for XP_011544297.1

    UniProtKB/Swiss-Prot
    O15047
    Conserved Domains (6) summary
    smart00317
    Location:15681691
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00360
    Location:101166
    RRM; RNA recognition motif
    smart00508
    Location:16911707
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:14711707
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd12548
    Location:92186
    RRM_Set1A; RNA recognition motif in vertebrate histone-lysine N-methyltransferase Setd1A (Set1A)
    pfam11764
    Location:14181558
    N-SET; COMPASS (Complex proteins associated with Set1p) component N
  2. XM_011545994.1XP_011544296.1  

    See identical proteins and their annotated locations for XP_011544296.1

    UniProtKB/Swiss-Prot
    O15047
    Conserved Domains (6) summary
    smart00317
    Location:15681691
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00360
    Location:101166
    RRM; RNA recognition motif
    smart00508
    Location:16911707
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:14711707
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd12548
    Location:92186
    RRM_Set1A; RNA recognition motif in vertebrate histone-lysine N-methyltransferase Setd1A (Set1A)
    pfam11764
    Location:14181558
    N-SET; COMPASS (Complex proteins associated with Set1p) component N
  3. XM_005255723.1XP_005255780.1  

    See identical proteins and their annotated locations for XP_005255780.1

    UniProtKB/Swiss-Prot
    O15047
    Conserved Domains (6) summary
    smart00317
    Location:15681691
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00360
    Location:101166
    RRM; RNA recognition motif
    smart00508
    Location:16911707
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:14711707
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd12548
    Location:92186
    RRM_Set1A; RNA recognition motif in vertebrate histone-lysine N-methyltransferase Setd1A (Set1A)
    pfam11764
    Location:14181558
    N-SET; COMPASS (Complex proteins associated with Set1p) component N
  4. XM_006721106.2XP_006721169.1  

    See identical proteins and their annotated locations for XP_006721169.1

    UniProtKB/Swiss-Prot
    O15047
    Conserved Domains (6) summary
    smart00317
    Location:15681691
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00360
    Location:101166
    RRM; RNA recognition motif
    smart00508
    Location:16911707
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:14711707
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd12548
    Location:92186
    RRM_Set1A; RNA recognition motif in vertebrate histone-lysine N-methyltransferase Setd1A (Set1A)
    pfam11764
    Location:14181558
    N-SET; COMPASS (Complex proteins associated with Set1p) component N
  5. XM_011545996.1XP_011544298.1  

    See identical proteins and their annotated locations for XP_011544298.1

    UniProtKB/Swiss-Prot
    O15047
    Conserved Domains (6) summary
    smart00317
    Location:15681691
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00360
    Location:101166
    RRM; RNA recognition motif
    smart00508
    Location:16911707
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:14711707
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd12548
    Location:92186
    RRM_Set1A; RNA recognition motif in vertebrate histone-lysine N-methyltransferase Setd1A (Set1A)
    pfam11764
    Location:14181558
    N-SET; COMPASS (Complex proteins associated with Set1p) component N

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    32285622..32312985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)