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RIMS2 regulating synaptic membrane exocytosis 2 [ Homo sapiens (human) ]

Gene ID: 9699, updated on 24-Jan-2015
Official Symbol
RIMS2provided by HGNC
Official Full Name
regulating synaptic membrane exocytosis 2provided by HGNC
Primary source
HGNC:HGNC:17283
See related
Ensembl:ENSG00000176406; HPRD:09436; MIM:606630
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OBOE; RIM2; RAB3IP3
Orthologs
See RIMS2 in MapViewer
Location:
8q22.3
Exon count:
40
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 8 NC_000008.11 (103500198..104254428)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (104512426..105266656)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial folate carrier), member 32 Neighboring gene collagen triple helix repeat containing 1 Neighboring gene DDB1 and CUL4 associated factor 13 Neighboring gene mediator complex subunit 21 pseudogene Neighboring gene TAR (HIV-1) RNA binding protein 2 pseudogene Neighboring gene ribosomal protein S6 pseudogene 9 Neighboring gene dendrocyte expressed seven transmembrane protein Neighboring gene dihydropyrimidinase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
NHGRI GWA Catalog
  • Insulin secretion, organism-specific biosystem (from KEGG)
    Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0751, DKFZp781A0653

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab GTPase binding IEA
Inferred from Electronic Annotation
more info
 
ion channel binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion-dependent exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion-dependent exocytosis of neurotransmitter ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of excitatory postsynaptic membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of inhibitory postsynaptic membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic active zone TAS
Traceable Author Statement
more info
PubMed 
presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
regulating synaptic membrane exocytosis protein 2
Names
regulating synaptic membrane exocytosis protein 2
RIM 2
nuclear protein
Rab3-interacting protein
RAB3 interacting protein 3
rab-3-interacting protein 3
rab3-interacting molecule 2
rab-3-interacting molecule 2
non-small cell lung cancer RimL3a protein
non-small cell lung cancer RimL3c protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100117.2NP_001093587.1  regulating synaptic membrane exocytosis protein 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK126939, AP002849, BC043144
    UniProtKB/Swiss-Prot
    Q9UQ26
    Conserved Domains (4) summary
    cd04028
    Location:11801325
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:746869
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:593674
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02318
    Location:30154
    FYVE_2; FYVE-type zinc finger
  2. NM_001282881.1NP_001269810.1  regulating synaptic membrane exocytosis protein 2 isoform c

    See proteins identical to NP_001269810.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' structure compared to variant 1. The encoded isoform (c) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB018294, AP002849, BP230765
    Consensus CDS
    CCDS64948.1
    UniProtKB/Swiss-Prot
    Q9UQ26
    Conserved Domains (3) summary
    cd04028
    Location:10191164
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:582708
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:448529
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. NM_001282882.1NP_001269811.1  regulating synaptic membrane exocytosis protein 2 isoform d

    See proteins identical to NP_001269811.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' structure compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AP002849, BP360433, CN361794
    Consensus CDS
    CCDS64949.1
    UniProtKB/Swiss-Prot
    Q9UQ26
    Related
    ENSP00000342051, ENST00000339750
    Conserved Domains (1) summary
    cd04028
    Location:116261
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
  4. NM_014677.4NP_055492.3  regulating synaptic membrane exocytosis protein 2 isoform b

    See proteins identical to NP_055492.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and has multiple differences in the presence and absence of exons in the 5' and mid-coding regions, compared to variant 1. The resulting protein (isoform b) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK126939, AP002849, BC043144, BP230765
    Consensus CDS
    CCDS43761.1
    UniProtKB/Swiss-Prot
    Q9UQ26
    Conserved Domains (4) summary
    cd04028
    Location:9941139
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:762864
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11 

    Range
    103500198..104254428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716699.1XP_006716762.1  

    Conserved Domains (5) summary
    cd04028
    Location:14021547
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:771897
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:9981100
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:637718
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02318
    Location:30198
    FYVE_2; FYVE-type zinc finger
  2. XM_006716690.1XP_006716753.1  

    Conserved Domains (5) summary
    cd04028
    Location:14871632
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:837960
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:10611163
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:684765
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02318
    Location:148198
    FYVE_2; FYVE-type zinc finger
  3. XM_006716691.1XP_006716754.1  

    Conserved Domains (5) summary
    cd04028
    Location:14861631
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:837960
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:10611163
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:684765
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02318
    Location:30198
    FYVE_2; FYVE-type zinc finger
  4. XM_006716692.1XP_006716755.1  

    Conserved Domains (5) summary
    cd04028
    Location:14651610
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:837960
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:10611163
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:684765
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02318
    Location:30198
    FYVE_2; FYVE-type zinc finger
  5. XM_006716693.1XP_006716756.1  

    Conserved Domains (5) summary
    cd04028
    Location:12931438
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:837960
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:10611163
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:684765
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02318
    Location:148198
    FYVE_2; FYVE-type zinc finger
  6. XM_005251108.1XP_005251165.1  

    Conserved Domains (4) summary
    cd04028
    Location:13631508
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:814940
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:680761
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02318
    Location:148194
    FYVE_2; FYVE-type zinc finger
  7. XM_006716695.1XP_006716758.1  

    Conserved Domains (4) summary
    cd04031
    Location:837960
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:684765
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam01485
    Location:129161
    IBR; IBR domain
    pfam02318
    Location:148198
    FYVE_2; FYVE-type zinc finger
  8. XM_005251106.1XP_005251163.1  

    Conserved Domains (5) summary
    cd04028
    Location:14051550
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:774900
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:10011103
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:640721
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02318
    Location:30154
    FYVE_2; FYVE-type zinc finger
  9. XM_005251107.1XP_005251164.1  

    Conserved Domains (4) summary
    cd04028
    Location:13831528
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:774900
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:640721
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02318
    Location:30154
    FYVE_2; FYVE-type zinc finger
  10. XM_006716694.1XP_006716757.1  

    Conserved Domains (4) summary
    cd04028
    Location:11871332
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:762864
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  11. XM_006716696.1XP_006716759.1  

    Conserved Domains (1) summary
    cd04028
    Location:275420
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
  12. XM_006716697.1XP_006716760.1  

    Conserved Domains (1) summary
    cd04028
    Location:259404
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
  13. XM_006716698.1XP_006716761.1  

    Conserved Domains (1) summary
    cd04028
    Location:144289
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 

    Range
    104553751..105307457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000140.1 

    Range
    99713363..100467719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)