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KIAA0391 KIAA0391 [ Homo sapiens (human) ]

Gene ID: 9692, updated on 12-May-2016
Official Symbol
KIAA0391provided by HGNC
Official Full Name
KIAA0391provided by HGNC
Primary source
HGNC:HGNC:19958
See related
Ensembl:ENSG00000100890 Ensembl:ENSG00000258790 HPRD:18711; MIM:609947; Vega:OTTHUMG00000170997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRPP3; PRORP
Orthologs
Location:
14q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (35121283..35274078)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (35591527..35743284)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene signal recognition particle 54kDa Neighboring gene family with sequence similarity 177 member A1 Neighboring gene uncharacterized LOC101927178 Neighboring gene protein phosphatase 2 regulatory subunit B''gamma Neighboring gene ribosomal protein L23a pseudogene 70 Neighboring gene septin 7 pseudogene 1 Neighboring gene mitochondrial ribosomal protein L57 pseudogene 8 Neighboring gene divergent-paired related homeobox pseudogene 3 Neighboring gene ribosomal protein L7a pseudogene 3 Neighboring gene ribosomal protein L9 pseudogene 3 Neighboring gene proteasome subunit alpha 6 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analysis identifies three psoriasis susceptibility loci.
NHGRI GWA Catalog
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • rRNA processing, organism-specific biosystem (from REACTOME)
    rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
  • tRNA processing, organism-specific biosystem (from REACTOME)
    tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...
  • tRNA processing in the mitochondrion, organism-specific biosystem (from REACTOME)
    tRNA processing in the mitochondrion, organism-specific biosystemEach strand of the circular mitochondrial genome is transcribed to yield long polycistronic transcripts, the heavy strand transcript and the light strand transcript, which are then cleaved to yield t...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ribonuclease P activity EXP
Inferred from Experiment
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
mitochondrial tRNA processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
Preferred Names
mitochondrial ribonuclease P protein 3
Names
mitochondrial RNase P protein 3
mitochondrial RNase P subunit 3
proteinaceous RNase P

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256678.1NP_001243607.1  mitochondrial ribonuclease P protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001243607.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB002389, AK304066, CX760644, DA459368
    Consensus CDS
    CCDS58312.1
    UniProtKB/Swiss-Prot
    O15091
    Related
    ENSP00000250377, OTTHUMP00000244863, ENST00000250377, OTTHUMT00000411148
    Conserved Domains (1) summary
    sd00004
    Location:174204
    PPR; PPR repeat [structural motif]
  2. NM_001256679.1NP_001243608.1  mitochondrial ribonuclease P protein 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI431599, AK301931, BP373829, CX760644, DA459368
    Consensus CDS
    CCDS58313.1
    UniProtKB/Swiss-Prot
    O15091
    Related
    ENSP00000474620, OTTHUMP00000244874, ENST00000604948, OTTHUMT00000411146
    Conserved Domains (1) summary
    sd00004
    Location:79109
    PPR; PPR repeat [structural motif]
  3. NM_001256680.1NP_001243609.1  mitochondrial ribonuclease P protein 3 isoform 4

    See identical proteins and their annotated locations for NP_001243609.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 4 and 5 encode the same isoform (4), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA838769, BX161487, DC404874
    Consensus CDS
    CCDS58314.1
    UniProtKB/Swiss-Prot
    O15091
    Related
    ENSP00000474299, OTTHUMP00000244909, ENST00000605870, OTTHUMT00000411151
  4. NM_001256681.1NP_001243610.1  mitochondrial ribonuclease P protein 3 isoform 4

    See identical proteins and their annotated locations for NP_001243610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 4 and 5 encode the same isoform (4), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI431599, BQ063741, DC404874, DT217089
    Consensus CDS
    CCDS58314.1
    UniProtKB/Swiss-Prot
    O15091
    Related
    ENSP00000324697, ENST00000321130
  5. NM_014672.3NP_055487.2  mitochondrial ribonuclease P protein 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_055487.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA838769, BX161394, CX760644, DA459368
    Consensus CDS
    CCDS32063.1
    UniProtKB/Swiss-Prot
    O15091
    Related
    ENSP00000440915, OTTHUMP00000244840, ENST00000534898, OTTHUMT00000411149
    Conserved Domains (1) summary
    sd00004
    Location:174204
    PPR; PPR repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    35121283..35274078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537411.1XP_011535713.1  

    See identical proteins and their annotated locations for XP_011535713.1

    UniProtKB/Swiss-Prot
    O15091
    Conserved Domains (1) summary
    sd00004
    Location:174204
    PPR; PPR repeat [structural motif]
  2. XM_011537410.1XP_011535712.1  

    See identical proteins and their annotated locations for XP_011535712.1

    UniProtKB/Swiss-Prot
    O15091
    Conserved Domains (1) summary
    sd00004
    Location:174204
    PPR; PPR repeat [structural motif]
  3. XM_005268237.2XP_005268294.1  

    See identical proteins and their annotated locations for XP_005268294.1

    UniProtKB/Swiss-Prot
    O15091
    Conserved Domains (1) summary
    sd00004
    Location:174204
    PPR; PPR repeat [structural motif]
  4. XM_011537409.1XP_011535711.1  

    See identical proteins and their annotated locations for XP_011535711.1

    UniProtKB/Swiss-Prot
    O15091
    Conserved Domains (1) summary
    sd00004
    Location:174204
    PPR; PPR repeat [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    35591261..35743020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)