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TTC37 tetratricopeptide repeat domain 37 [ Homo sapiens (human) ]

Gene ID: 9652, updated on 8-May-2016
Official Symbol
TTC37provided by HGNC
Official Full Name
tetratricopeptide repeat domain 37provided by HGNC
Primary source
HGNC:HGNC:23639
See related
Ensembl:ENSG00000198677 HPRD:11079; MIM:614589; Vega:OTTHUMG00000121165
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ski3; THES; KIAA0372
Summary
This gene encodes a protein with twenty tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Mutations in this gene are associated with trichohepatoenteric syndrome. [provided by RefSeq, Jul 2010]
Orthologs
Location:
5q15
Exon count:
43
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (95463895..95555005, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (94799599..94890709, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379089 Neighboring gene family with sequence similarity 81 member B Neighboring gene chromosome 14 open reading frame 166 pseudogene Neighboring gene arylsulfatase family member K Neighboring gene G protein-coupled receptor 150

  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • Ski complex, organism-specific biosystem (from KEGG)
    Ski complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • Ski complex, conserved biosystem (from KEGG)
    Ski complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0372, MGC32587

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Ski complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcriptionally active chromatin IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
tetratricopeptide repeat protein 37
Names
SKI3 homolog
TPR repeat protein 37
thespin
tricho-hepatic-enteric syndrome protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023414.1 RefSeqGene

    Range
    5001..96111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_173

mRNA and Protein(s)

  1. NM_014639.3NP_055454.1  tetratricopeptide repeat protein 37

    See identical proteins and their annotated locations for NP_055454.1

    Status: REVIEWED

    Source sequence(s)
    AB002370
    Consensus CDS
    CCDS4072.1
    UniProtKB/Swiss-Prot
    Q6PGP7
    Related
    ENSP00000351596, OTTHUMP00000149977, ENST00000358746, OTTHUMT00000241651
    Conserved Domains (6) summary
    pfam00515
    Location:861894
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:275335
    TPR_11; TPR repeat
    pfam13432
    Location:1072
    TPR_16; Tetratricopeptide repeat
    TIGR02917
    Location:3221272
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:530555
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:566592
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    95463895..95555005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_948312.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    94232235..94323386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)