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    CD47 CD47 molecule [ Homo sapiens ]

    Gene ID: 961, updated on 11-May-2012
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    Summary

    Official Symbol
    CD47provided by HGNC
    Official Full Name
    CD47 moleculeprovided by HGNC
    Primary source
    HGNC:1682
    See related
    Ensembl:ENSG00000196776; HPRD:03017; MIM:601028; Vega:OTTHUMG00000044216
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IAP; OA3; MER6
    Summary
    This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
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    Genomic context

    Location :
    3q13.1-q13.2
    Sequence :
    Chromosome: 3; NC_000003.11 (107761941..107809935, complement)
    See CD47 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC151658 Neighboring gene uncharacterized LOC285205 Neighboring gene intraflagellar transport 57 homolog (Chlamydomonas) Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 17 Neighboring gene HERV-H LTR-associating 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane. De Oliveira S, et al. Biochim Biophys Acta, 2012 Mar. PMID 22079249.
    2. Cofactor regulation of C5a chemotactic activity in physiological fluids. Requirement for the vitamin D binding protein, thrombospondin-1 and its receptors. Trujillo G, et al. Mol Immunol, 2011 Dec. PMID 22014686.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. Heparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1. Kaur S, et al. J Biol Chem, 2011 Apr 29. PMID 21343308.
    5. The CD47 pathway is deregulated in human immune thrombocytopenia. Catani L, et al. Exp Hematol, 2011 Apr. PMID 21211546.

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. a specific and age-dependent interaction of soluble fibrinogen with human RBC membrane; additionally we present CD47 as a putative mediator in this process. This interaction may contribute to RBC hyperaggregation in inflammation.
      Title: Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane.
    2. vitamin D binding protein does not bind to TSP-1, CD36 or CD47
      Title: Cofactor regulation of C5a chemotactic activity in physiological fluids. Requirement for the vitamin D binding protein, thrombospondin-1 and its receptors.
    3. Reduced levels of CD47 are expected to result in a reduced level of phosphatidylserine exposure following ligation.
      Title: 4.1R-deficient human red blood cells have altered phosphatidylserine exposure pathways and are deficient in CD44 and CD47 glycoproteins.
    4. inhibition of T cell receptor signaling by thrombospondin-1 is mediated by CD47 and requires its modification at Ser(64).
      Title: Heparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1.
    5. Amyloid-beta inhibits No-cGMP signaling in a CD36- and CD47-dependent manner
      Title: Amyloid-β inhibits No-cGMP signaling in a CD36- and CD47-dependent manner.
    6. Results demonstrate that the CD47 pathway in ITP patients abnormally modulates platelet homeostasis.
      Title: The CD47 pathway is deregulated in human immune thrombocytopenia.
    7. Increased CD47 expression correlated with high amounts of calreticulin on cancer cells and was necessary for protection from calreticulin-mediated phagocytosis.
      Title: Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47.
    8. Poor prognosis of breast cancer patients with high expression of CD47 is due to an active CD47/SIRPA signaling pathway in circulating cells.
      Title: Correlated expression of CD47 and SIRPA in bone marrow and in peripheral blood predicts recurrence in breast cancer patients.
    9. Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47
      Title: Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47.
    10. The role of cis dimerization of signal regulatory protein alpha (SIRPalpha) in binding to CD47.
      Title: The role of cis dimerization of signal regulatory protein alpha (SIRPalpha) in binding to CD47.
    Submit: New GeneRIF Correction See all (60)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001768.1 NP_003237.2 THBS1    BIND  PubMed IAP interacts with TS-1. This interaction was modeled on a demonstrated interaction between pig IAP and human TS-1. 
    Q08722 Q12983 BNIP3    HPRD  PubMed  
    Q08722 P16452 EPB42    HPRD  PubMed  
    Q08722 P25445 FAS    HPRD  PubMed  
    Q08722 P63096 GNAI1    HPRD  PubMed  
    Q08722 P06756 ITGAV    HPRD  PubMed  
    Q08722 P41231 P2RY2    HPRD  PubMed  
    Q08722 Q05397 PTK2    HPRD  PubMed  
    Q08722 Q02094 RHAG    HPRD  PubMed  
    Q08722 P78324 SIRPA    HPRD  PubMed  
    Q08722 P07996 THBS1    HPRD  PubMed  
    Q08722 Q9UMX0 UBQLN1    HPRD  PubMed  
    BioGRID:107399 BioGRID:107132 BNIP3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107399 BioGRID:109894 ITGB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107399 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
      Integrins in angiogenesis, organism-specific biosystem
      Integrins in angiogenesis
    • Signal regulatory protein (SIRP) family interactions, organism-specific biosystem (from REACTOME)
      Signal regulatory protein (SIRP) family interactions, organism-specific biosystemSignal regulatory protein (SIRP)alpha, also known as SHPS-1 or SIRPA or CD172a, is a transmembrane protein expressed mostly on myeloid cells. CD47, a widely expressed transmembrane protein, is a liga...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    thrombospondin receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrin-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    leukocyte surface antigen CD47
    Names
    leukocyte surface antigen CD47
    CD47 glycoprotein
    Rh-related antigen
    integrin associated protein
    integrin-associated protein
    integrin-associated signal transducer
    antigenic surface determinant protein OA3
    antigen identified by monoclonal antibody 1D8
    CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001777.3 → NP_001768.1  leukocyte surface antigen CD47 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC012020, CB995865, X69398
      Consensus CDS
      CCDS43126.1
      UniProtKB/Swiss-Prot
      Q08722
      Related
      ENSP00000355361, OTTHUMP00000041153, ENST00000361309, OTTHUMT00000102793
      Conserved Domains (2) summary
      pfam04549
      Location:143 – 300
      Blast Score: 391
      CD47; CD47 transmembrane region
      pfam08204
      Location:20 – 136
      Blast Score: 333
      V-set_CD47; CD47 immunoglobulin-like domain

    2. NM_198793.2 → NP_942088.1  leukocyte surface antigen CD47 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC012020, BC037306, CB995865
      Consensus CDS
      CCDS43125.1
      UniProtKB/Swiss-Prot
      Q08722
      Related
      ENSP00000347512, OTTHUMP00000041152, ENST00000355354, OTTHUMT00000102791
      Conserved Domains (2) summary
      pfam04549
      Location:143 – 300
      Blast Score: 377
      CD47; CD47 transmembrane region
      pfam08204
      Location:20 – 136
      Blast Score: 327
      V-set_CD47; CD47 immunoglobulin-like domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      107761941..107809935, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      105135236..105183196, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025079.1: Suppressed sequence

      Description
      NM_001025079.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_001025080.1: Suppressed sequence

      Description
      NM_001025080.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate and lacks homolog support.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC012020.17 (32571..80565) None
    genomic AF540016.1 AAQ11189.1
    genomic CH471052.2 EAW79732.1
      EAW79733.1
      EAW79734.1
    mRNA AI701980.1 None
    mRNA AK096670.1 None
    mRNA AK124152.1 None
    mRNA AK289813.1 BAF82502.1
    mRNA AL832675.1 None
    mRNA BC010016.2 AAH10016.1
    mRNA BC012884.1 AAH12884.1
    mRNA BC037306.1 AAH37306.1
    mRNA BC042889.1 None
    mRNA BC045593.1 None
    mRNA BC053959.1 None
    mRNA BI753986.1 None
    mRNA BT006907.1 AAP35553.1
    mRNA BX640889.1 None
    mRNA CB995865.1 None
    mRNA X69398.1 CAA49196.1
    mRNA Z25521.1 CAA80977.1
    other-genetic DQ890756.2 ABM81682.1
    other-genetic DQ891811.2 ABM82737.1
    other-genetic DQ893920.2 ABM84846.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08722.1 GenPept UniProtKB/Swiss-Prot:Q08722
    Q71A41 GenPept UniProtKB/TrEMBL:Q71A41
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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