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    CD44 CD44 molecule (Indian blood group) [ Homo sapiens ]

    Gene ID: 960, updated on 20-May-2012
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    Summary

    Official Symbol
    CD44provided by HGNC
    Official Full Name
    CD44 molecule (Indian blood group)provided by HGNC
    Primary source
    HGNC:1681
    Locus tag
    AL133330.1
    See related
    Ensembl:ENSG00000026508; HPRD:00115; MIM:107269; Vega:OTTHUMG00000044388
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; MGC10468
    Summary
    The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    11p13
    Sequence :
    Chromosome: 11; NC_000011.9 (35160417..35253949)
    See CD44 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase complex, component X Neighboring gene microRNA 1343 Neighboring gene uncharacterized LOC100507144 Neighboring gene uncharacterized LOC100507164 Neighboring gene solute carrier family 1 (glial high affinity glutamate transporter), member 2 Neighboring gene peptidase domain containing associated with muscle regeneration 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells. Tamada M, et al. Cancer Res, 2012 Mar 15. PMID 22293754.
    2. CD44 proteolysis increases CREB phosphorylation and sustains proliferation of thyroid cancer cells. De Falco V, et al. Cancer Res, 2012 Mar 15. PMID 22271686.
    3. Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Zaytseva YY, et al. Cancer Res, 2012 Mar 15. PMID 22266115.
    4. CD44 expression in oro-pharyngeal carcinoma tissues and cell lines. Rajarajan A, et al. PLoS One, 2012. PMID 22242150.
    5. Intense CD44 expression is a negative prognostic factor in tonsillar and base of tongue cancer. Lindquist D, et al. Anticancer Res, 2012 Jan. PMID 22213301.

    See all (532) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. It was found that elevated expression of fatty acid synthase is associated with advanced stages of colorectal cancer and liver metastasis. Targeted knockdown of fatty acid synthase abolished CD44 expression.
      Title: Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer.
    2. Together, these findings reveal a CD44-CREB signaling pathway that is needed to sustain cancer cell proliferation, potentially offering new molecular targets for therapeutic intervention in thyroid carcinoma.
      Title: CD44 proteolysis increases CREB phosphorylation and sustains proliferation of thyroid cancer cells.
    3. It was found that CD44 (a cell surface marker for cancer stem cells) interacts with pyruvate kinase M2 and thereby enhances the glycolytic phenotype of cancer cells that are either deficient in p53 or exposed to hypoxia.
      Title: Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells.
    4. Bioinformatic processing of large numbers of global gene expression analyses demonstrated elevated CD44 expression in head and neck cancer.
      Title: CD44 expression in oro-pharyngeal carcinoma tissues and cell lines.
    5. Although CD133(+) and CD133(+)/CD44(+) were detectable in human primary gastric cancers, they neither expressed stem-like properties nor exhibited tumor-initiating properties in xenograft transplantation experiments.
      Title: CD133 and CD44 cell surface markers do not identify cancer stem cells in primary human gastric tumors.
    6. CD44+/CD24(-or low) phenotypic radiation resistance of breast cancer cells is mediated through the enhanced activation of ATM signaling
      Title: The phenotypic radiation resistance of CD44+/CD24(-or low) breast cancer cells is mediated through the enhanced activation of ATM signaling.
    7. Survivin is a novel target of CD44-promoted breast tumor invasion
      Title: Survivin is a novel target of CD44-promoted breast tumor invasion.
    8. Increased expression of CD44, CD166 and CD133 from normal mucosa samples to adenoma and carcinoma was linked to tumor progression in tumors of the ampulla of Vater.
      Title: Effect of EpCAM, CD44, CD133 and CD166 expression on patient survival in tumours of the ampulla of Vater.
    9. Among CD44s and its variant isoforms,v5, v6, in this study, variant isoform v6 may serve as a marker in detecting high-risk leukoplakias.
      Title: Quantitative assessment of expression of cell adhesion molecule (CD44) splice variants: CD44 standard (CD44s) and v5, v6 isoforms in oral leukoplakias: an immunohistochemical study.
    10. These findings suggest that CD44(+)/CD24(-/low) breast cancer stem-like cells play an important role in the clinical behavior of triple-negative breast cancer.
      Title: CD44(+)/CD24(-/low) cancer stem/progenitor cells are more abundant in triple-negative invasive breast carcinoma phenotype and are associated with poor outcome.
    Submit: New GeneRIF Correction See all (430)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Blood group, Indian system

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr potentiates the suppression of CD44 by glucocorticoids via the glucocorticoid receptor pathway PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_000601.2 NP_005219.2 EGFR    BIND  PubMed CD44 interacts with EGFR. 
    P16070 P16157 ANK1    HPRD  PubMed  
    P16070 Q92888 ARHGEF1    HPRD  PubMed  
    P16070 Q9NZN5 ARHGEF12    HPRD  PubMed  
    P16070 P01730 CD4    HPRD  PubMed  
    P16070 P16070 CD44    HPRD  PubMed  
    P16070 P04233 CD74    HPRD  PubMed  
    P16070 Q05707 COL14A1    HPRD  PubMed  
    P16070 P02452 COL1A1    HPRD  PubMed  
    P16070 P08123 COL1A2    HPRD  PubMed  
    P16070 P41240 CSK    HPRD  PubMed  
    P16070 Q13316 DMP1    HPRD  PubMed  
    P16070 P00533 EGFR    HPRD  PubMed  
    P16070 P11171 EPB41    HPRD  PubMed  
    P16070 Q15303 ERBB4    HPRD  PubMed  
    P16070 P15311 EZR    HPRD  PubMed  
    P16070 P09038 FGF2    HPRD  PubMed  
    P16070 P06241 FYN    HPRD  PubMed  
    P16070 P41250 GARS    HPRD  PubMed  
    P16070 Q99075 HBEGF    HPRD  PubMed  
    P16070 O75330 HMMR    HPRD  PubMed  
    P16070 P17936 IGFBP3    HPRD  PubMed  
    P16070 P06239 LCK    HPRD  PubMed  
    P16070 Q13477 MADCAM1    HPRD  PubMed  
    P16070 P03956 MMP1    HPRD  PubMed  
    P16070 P09237 MMP7    HPRD  PubMed  
    P16070 P14780 MMP9    HPRD  PubMed  
    P16070 P35240 NF2    HPRD  PubMed  
    P16070 Q16512 PKN1    HPRD  PubMed  
    P16070 P16581 SELE    HPRD  PubMed  
    P16070 P10451 SPP1    HPRD  PubMed  
    P16070 P10124 SRGN    HPRD  PubMed  
    P16070 P36897 TGFBR1    HPRD  PubMed  
    P16070 P37173 TGFBR2    HPRD  PubMed  
    P16070 Q13009 TIAM1    HPRD  PubMed  
    P16070 P52735 VAV2    HPRD  PubMed  
    P16070 P13611 VCAN    HPRD  PubMed  
    BioGRID:107398 BioGRID:114585 ARHGEF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107398 BioGRID:113219 COL14A1    BioGRID  PubMed Co-purification 
    BioGRID:107398 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-Western 
    AAC79806.1 EPB41L3    BIND  PubMed EPB41L3 (DAL-1) interacts with an unspecified isoform of CD44. 
    BioGRID:107398 BioGRID:108376 ERBB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107398 BioGRID:108378 ERBB4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107398 BioGRID:113271 EZR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107398 BioGRID:108621 FN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107398 BioGRID:108810 FYN    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:107398 BioGRID:108172 HBEGF    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107398 BioGRID:109707 IGFBP3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107398 BioGRID:110124 LCK    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:107398 BioGRID:110459 MMP7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107398 BioGRID:110584 MSN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107398 BioGRID:110844 NF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107398 BioGRID:111752 PTPRC    BioGRID  PubMed Co-fractionation 
    BioGRID:107398 BioGRID:112592 SRC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107398 BioGRID:112904 TGFBR1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107398 BioGRID:112930 TIAM1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107398 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107398 BioGRID:113253 VAV2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107398 BioGRID:107844 VCAN    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • Osteopontin-mediated events, organism-specific biosystem (from Pathway Interaction Database)
      Osteopontin-mediated events, organism-specific biosystem
      Osteopontin-mediated events
    • Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem (from Pathway Interaction Database)
      Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem
      Paxillin-independent events mediated by a4b1 and a4b7
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Shigellosis, organism-specific biosystem (from KEGG)
      Shigellosis, organism-specific biosystemShigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestina...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    collagen binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    hyaluronic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    hyaluronic acid binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    hyalurononglucosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cartilage development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell-cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cell-matrix adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    hyaluronan catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    monocyte aggregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of heterotypic cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CD44 antigen
    Names
    CD44 antigen
    epican
    Hermes antigen
    hyaluronate receptor
    phagocytic glycoprotein 1
    heparan sulfate proteoglycan
    cell surface glycoprotein CD44
    extracellular matrix receptor III
    chondroitin sulfate proteoglycan 8
    GP90 lymphocyte homing/adhesion receptor
    hematopoietic cell E- and L-selectin ligand
    homing function and Indian blood group system
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008937.1 RefSeqGene

      Range
      5001..98533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000610.3 → NP_000601.3  CD44 antigen isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. It encodes the longest isoform (1).
      Source sequence(s)
      AK127622, AL832642, AY101192, BC004372, BF828674, BF872530, CD721908
      Consensus CDS
      CCDS7897.1
      UniProtKB/Swiss-Prot
      P16070
      Related
      ENSP00000398632, OTTHUMP00000232489, ENST00000428726, OTTHUMT00000388927
      Conserved Domains (1) summary
      cd03516
      Location:26 – 170
      Blast Score: 498
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    2. NM_001001389.1 → NP_001001389.1  CD44 antigen isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1.
      Source sequence(s)
      AK127622, AL832642, AY101192, BC004372, BF828674, CD721908
      Consensus CDS
      CCDS31455.1
      UniProtKB/Swiss-Prot
      P16070
      Related
      ENSP00000389830, OTTHUMP00000232488, ENST00000415148, OTTHUMT00000388926
      Conserved Domains (1) summary
      cd03516
      Location:26 – 170
      Blast Score: 496
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    3. NM_001001390.1 → NP_001001390.1  CD44 antigen isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as CD44R, lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK127622, AL832642, AY101192, BG946113, CD721908
      Consensus CDS
      CCDS31456.1
      UniProtKB/Swiss-Prot
      P16070
      Related
      ENSP00000392331, OTTHUMP00000232491, ENST00000433892, OTTHUMT00000388929
      Conserved Domains (1) summary
      cd03516
      Location:26 – 170
      Blast Score: 493
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    4. NM_001001391.1 → NP_001001391.1  CD44 antigen isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (4) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK127622, AL832642, AY101192, CD721908
      Consensus CDS
      CCDS31457.1
      UniProtKB/Swiss-Prot
      P16070
      Related
      ENSP00000263398, OTTHUMP00000232487, ENST00000263398, OTTHUMT00000388924
      Conserved Domains (1) summary
      cd03516
      Location:26 – 170
      Blast Score: 496
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    5. NM_001001392.1 → NP_001001392.1  CD44 antigen isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks multiple coding-exons compared to variant 1. The translation frame is changed. The resulting isoform (5), also known as CD44 isoform RC, has a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK127622, AL832642, AY101192, CD721908, W47313
      Consensus CDS
      CCDS31458.1
      UniProtKB/TrEMBL
      O95370
      UniProtKB/Swiss-Prot
      P16070
      Related
      ENSP00000278386, OTTHUMP00000232492, ENST00000278386, OTTHUMT00000388930
      Conserved Domains (1) summary
      cl02612
      Location:26 – 118
      Blast Score: 227
      Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...

    6. NM_001202555.1 → NP_001189484.1  CD44 antigen isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), also known as CD44R2, lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (6) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AL133330, AL832642, EF581837
      Consensus CDS
      CCDS55754.1
      UniProtKB/Swiss-Prot
      P16070
      Related
      ENSP00000404447, OTTHUMP00000232493, ENST00000434472, OTTHUMT00000388931
      Conserved Domains (1) summary
      cd03516
      Location:26 – 170
      Blast Score: 493
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    7. NM_001202556.1 → NP_001189485.1  CD44 antigen isoform 7 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (7) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AL133330, AL832642, FJ216964
      Consensus CDS
      CCDS55755.1
      UniProtKB/Swiss-Prot
      P16070
      Related
      ENSP00000309732, OTTHUMP00000232494, ENST00000352818, OTTHUMT00000388932
      Conserved Domains (1) summary
      cd03516
      Location:26 – 170
      Blast Score: 498
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    8. NM_001202557.1 → NP_001189486.1  CD44 antigen isoform 8 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), also known as Hermes, lacks multiple in-frame coding-exons and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (8) lacks an internal segment and has a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AL133330, AL832642, M25078
      UniProtKB/Swiss-Prot
      P16070
      Related
      ENSP00000398099, OTTHUMP00000232495, ENST00000442151, OTTHUMT00000388933
      Conserved Domains (1) summary
      cd03516
      Location:26 – 170
      Blast Score: 488
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      35160417..35253949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      34858894..34952423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL133330.14 CAC10345.1
      CAC10346.1
      CAC10347.1
      CAC10348.1
      CAC10349.1
    genomic AL136989.10 (100..5952) None
    genomic AL356215.11 (100..23571) None
    genomic CH471064.2 EAW68144.1
      EAW68145.1
      EAW68146.1
      EAW68147.1
      EAW68148.1
      EAW68149.1
      EAW68150.1
      EAW68151.1
      EAW68152.1
      EAW68153.1
      EAW68154.1
      EAW68155.1
    genomic HI519530.1 CBX54346.1
    genomic L05423.1 AAB13622.1
      AAB13623.1
    genomic L05423.1 AAB13622.1
      AAB13623.1
    genomic L05424.1 AAB13624.1
      AAB13625.1
      AAB13626.1
      AAB13627.1
      AAB13628.1
    genomic S72928.1 AAB30429.1
    mRNA AB073901.1 None
    mRNA AF086543.1 None
    mRNA AF098641.1 AAC70782.1
    mRNA AJ251595.1 CAB61878.1
    mRNA AK123567.1 None
    mRNA AK127622.1 None
    mRNA AK129808.1 None
    mRNA AK290424.1 BAF83113.1
    mRNA AK297776.1 BAG60121.1
    mRNA AK304467.1 BAG65282.1
    mRNA AK307707.1 None
    mRNA AL832642.2 CAD89965.1
    mRNA AY101192.1 AAM50040.1
    mRNA AY101193.1 AAM50041.1
    mRNA BC004372.1 AAH04372.1
    mRNA BC052287.1 AAH52287.1
    mRNA BC067348.1 AAH67348.1
    mRNA BF828674.1 None
    mRNA BF872530.1 None
    mRNA BG946113.1 None
    mRNA CD721908.1 None
    mRNA D28447.1 BAA05813.1
    mRNA EF581837.1 ABQ59315.1
    mRNA FJ216964.1 ACI46596.1
    mRNA M24915.1 AAA35674.1
    mRNA M25078.1 AAA36138.1
    mRNA M59040.1 AAA51950.1
    mRNA M83324.1 None
    mRNA M83325.1 None
    mRNA M83326.1 None
    mRNA M83327.1 None
    mRNA M83328.1 None
    mRNA S66400.1 AAB27917.1
      AAB27918.2
      AAB27919.1
    mRNA S82326.1 AAD14389.1
    mRNA U40373.1 AAA82949.1
    mRNA W47313.1 None
    mRNA X55150.1 CAA38951.1
    mRNA X55938.1 CAA39404.1
    mRNA X56794.1 CAA40133.1
    mRNA X62739.1 CAA44602.1
    mRNA X66733.1 CAA47271.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95370 GenPept UniProtKB/TrEMBL:O95370
    P16070.3 GenPept UniProtKB/Swiss-Prot:P16070
    Q86UZ1 GenPept UniProtKB/TrEMBL:Q86UZ1
    Q99900 GenPept UniProtKB/TrEMBL:Q99900
    Q9H5A3 GenPept UniProtKB/TrEMBL:Q9H5A3
    Q9H5A4 GenPept UniProtKB/TrEMBL:Q9H5A4
    Q9H5A6 GenPept UniProtKB/TrEMBL:Q9H5A6
    Q9H5A7 GenPept UniProtKB/TrEMBL:Q9H5A7
    Q9P2Z2 GenPept UniProtKB/TrEMBL:Q9P2Z2
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