CD44 CD44 molecule (Indian blood group) [Homo sapiens (human)] - Gene

Summary

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Official Symbol: CD44provided by HGNC
Official Full Name: CD44 molecule (Indian blood group)provided by HGNC
Primary source: HGNC:1681
Locus tag: AL133330.1
See related: Ensembl:ENSG00000026508; HPRD:00115; MIM:107269; Vega:OTTHUMG00000044388
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III
Summary: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 11p13

Sequence :: Chromosome: 11; NC_000011.9 (35160417..35253949)

See CD44 in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Neither CD44H nor CD44v6 scores correlated with the osteopontin expression score or Ki-67 index. Osteopontin immunoexpression was highest in PCNSL, suggesting its probable role in its pathogenesis.
Title: Preferential up-regulation of osteopontin in primary central nervous system lymphoma does not correlate with putative receptor CD44v6 or CD44H expression.
Lipid rafts regulate interactions between CD44 and its binding partner ezrin in migrating breast cancer cells.
Title: Lipid raft association restricts CD44-ezrin interaction and promotion of breast cancer cell migration.
A CD44high/EGFRlow subpopulation within head and neck cancer cell lines shows an epithelial-mesenchymal transition phenotype and resistance to treatment.
Title: A CD44high/EGFRlow subpopulation within head and neck cancer cell lines shows an epithelial-mesenchymal transition phenotype and resistance to treatment.
High CD44v6/v7 expression is associated with acute promyelocytic leukemia.
Title: Prognostic significance of CD44v6/v7 in acute promyelocytic leukemia.
The lack of membranous CD44v6 in the rectal cancer invasive front could be used as a method to identify patients at increased risk for recurrent disease.
Title: Lack of CD44 variant 6 expression in rectal cancer invasive front associates with early recurrence.
Medullary and metaplastic carcinomas are the two types highly associated with high-grade breast carcinomas, basal-like and claudin-low molecular subtypes, and to the breast cancer stem cell phenotype CD44(+)/CD24(-/low)/ALDH1(+).
Title: Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological types.
Cytoplasmic CD44 and absence of nuclear Oct3/4 suggest that the cells of cardiac sarcomas may represent 'daughter' stem cells that no longer have the capacity for tumour initiation, but have subsequently developed new lines of partial differentiation.
Title: Primary cardiac sarcomas may develop from resident or bone marrow-derived mesenchymal stem cells: use of immunohistochemistry including CD44 and octamer binding protein 3/4.
Neither individual expression of CD24 or CD44, nor combined expression of CD44/CD24 was associated with recurrence of gastric carcinoma.
Title: CD44/CD24 expression in recurrent gastric cancer: a retrospective analysis.
Data indicate that resistance to UVB induced apoptosis in the alpha6 integrin(high+)/CD44(+) cells involved increased expression of TAp63 and was overcome by PI-3 kinase inhibition.
Title: α6 Integrin and CD44 enrich for a primary keratinocyte population that displays resistance to UV-induced apoptosis.
Data suggest that pulmonary metastasis is corrected with levels of Geminin, cleaved caspase-3, CD44, E-cadherin, epidermal growth factor receptor, and CD204 in cancer cells within permeated lymphatic vessels.
Title: Morphophenotypic characteristics of intralymphatic cancer and stromal cells susceptible to lymphogenic metastasis.

Submit: New GeneRIF Correction See all (504)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.

Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Env, gp160, envelope glycoprotein	env	CD44, which localizes exclusively to the plasma membrane and is absent from endosomes, is detected at HIV-1 Env budding sites and efficiently incorporated into HIV-1 particles	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 ectodomain fragment (amino acids 550-639) induces CD44 and -actin redistribution to the membrane lipid rafts on the human brain micro vascular endothelial cells	PubMed
Vpr, p15	vpr	HIV-1 Vpr potentiates the suppression of CD44 by glucocorticoids via the glucocorticoid receptor pathway	PubMed
matrix	gag	HIV-1 matrix protein co-localizes with syndecan-2, syndecan-4, and CD44v3 on activated CD4+ T cells to modulate TNF-alpha and IL2 production	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_000601.2	NP_005219.2	EGFR	BIND	PubMed	CD44 interacts with EGFR.
P16070	P16157	ANK1	HPRD	PubMed
P16070	Q92888	ARHGEF1	HPRD	PubMed
P16070	Q9NZN5	ARHGEF12	HPRD	PubMed
P16070	P01730	CD4	HPRD	PubMed
P16070	P16070	CD44	HPRD	PubMed
P16070	P04233	CD74	HPRD	PubMed
P16070	Q05707	COL14A1	HPRD	PubMed
P16070	P02452	COL1A1	HPRD	PubMed
P16070	P08123	COL1A2	HPRD	PubMed
P16070	P41240	CSK	HPRD	PubMed
P16070	Q13316	DMP1	HPRD	PubMed
P16070	P00533	EGFR	HPRD	PubMed
P16070	P11171	EPB41	HPRD	PubMed
P16070	Q15303	ERBB4	HPRD	PubMed
P16070	P15311	EZR	HPRD	PubMed
P16070	P09038	FGF2	HPRD	PubMed
P16070	P06241	FYN	HPRD	PubMed
P16070	P41250	GARS	HPRD	PubMed
P16070	Q99075	HBEGF	HPRD	PubMed
P16070	O75330	HMMR	HPRD	PubMed
P16070	P17936	IGFBP3	HPRD	PubMed
P16070	P06239	LCK	HPRD	PubMed
P16070	Q13477	MADCAM1	HPRD	PubMed
P16070	P03956	MMP1	HPRD	PubMed
P16070	P09237	MMP7	HPRD	PubMed
P16070	P14780	MMP9	HPRD	PubMed
P16070	P35240	NF2	HPRD	PubMed
P16070	Q16512	PKN1	HPRD	PubMed
P16070	P16581	SELE	HPRD	PubMed
P16070	P10451	SPP1	HPRD	PubMed
P16070	P10124	SRGN	HPRD	PubMed
P16070	P36897	TGFBR1	HPRD	PubMed
P16070	P37173	TGFBR2	HPRD	PubMed
P16070	Q13009	TIAM1	HPRD	PubMed
P16070	P52735	VAV2	HPRD	PubMed
P16070	P13611	VCAN	HPRD	PubMed
BioGRID:107398	BioGRID:114585	ARHGEF1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107398	BioGRID:107776	ATF2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107398	BioGRID:107049	BAG1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107398	BioGRID:107305	CAV1	BioGRID	PubMed	Co-localization
BioGRID:107398	BioGRID:113219	COL14A1	BioGRID	PubMed	Co-purification
BioGRID:107398	BioGRID:120226	DPP8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107398	BioGRID:108276	EGFR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107398	BioGRID:108309	ELAVL1	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:107398	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western
	AAC79806.1	EPB41L3	BIND	PubMed	EPB41L3 (DAL-1) interacts with an unspecified isoform of CD44.
BioGRID:107398	BioGRID:108376	ERBB2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107398	BioGRID:108378	ERBB4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107398	BioGRID:113271	EZR	BioGRID	PubMed	Reconstituted Complex
BioGRID:107398	BioGRID:108608	FLOT2	BioGRID	PubMed	Co-localization
BioGRID:107398	BioGRID:107208	FMNL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107398	BioGRID:108621	FN1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107398	BioGRID:108810	FYN	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation
BioGRID:107398	BioGRID:108172	HBEGF	BioGRID	PubMed	Reconstituted Complex
BioGRID:107398	BioGRID:109707	IGFBP3	BioGRID	PubMed	Reconstituted Complex
BioGRID:107398	BioGRID:114353	IQGAP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107398	BioGRID:109894	ITGB1	BioGRID	PubMed	Co-localization
BioGRID:107398	BioGRID:110124	LCK	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation
BioGRID:107398	BioGRID:110459	MMP7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107398	BioGRID:110584	MSN	BioGRID	PubMed	Reconstituted Complex
BioGRID:107398	BioGRID:110844	NF2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107398	BioGRID:111576	PRKCZ	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107398	BioGRID:111752	PTPRC	BioGRID	PubMed	Co-fractionation
BioGRID:107398	BioGRID:112411	SLC3A2	BioGRID	PubMed	Co-fractionation
BioGRID:107398	BioGRID:112592	SRC	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:107398	BioGRID:112651	STAT3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107398	BioGRID:112904	TGFBR1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107398	BioGRID:112930	TIAM1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107398	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107398	BioGRID:113253	VAV2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107398	BioGRID:107844	VCAN	BioGRID	PubMed	Reconstituted Complex
BioGRID:107398	BioGRID:113269	VHL	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
ECM-receptor interaction, organism-specific biosystem (from KEGG)
ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
ECM-receptor interaction, conserved biosystem (from KEGG)
ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
Epstein-Barr virus infection, conserved biosystem (from KEGG)
Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
Hematopoietic cell lineage, conserved biosystem (from KEGG)
Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
Hyaluronan metabolism, organism-specific biosystem (from REACTOME)
Hyaluronan metabolism, organism-specific biosystemHyaluronan (hyaluronic acid, hyaluronate or HA) is an anionic glycosaminoglycan (GAG) distributed widely throughout connective, epithelial, and neural tissues and most abundant in the extracellular m...
Hyaluronan uptake and degradation, organism-specific biosystem (from REACTOME)
Hyaluronan uptake and degradation, organism-specific biosystemHyaluronan (HA) turnover can occur locally at the tissue of origin, where it is taken up by cells to be degraded, or released into the lymphatic and vascular systems, where it can be eliminated by th...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Interferon Signaling, organism-specific biosystem (from REACTOME)
Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
Interferon gamma signaling, organism-specific biosystem (from REACTOME)
Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
MPS I - Hurler syndrome, organism-specific biosystem (from REACTOME)
MPS I - Hurler syndrome, organism-specific biosystemMucopolysaccharidosis type I (MPS I, Hurler syndrome, Hurler's disease, gargoylism, Scheie, Hirler-Scheie syndrome; MIM:607014, 607015 and 607016) is an autosomal recessive genetic disorder where th...
MPS II - Hunter syndrome, organism-specific biosystem (from REACTOME)
MPS II - Hunter syndrome, organism-specific biosystemMucopolysaccharidosis II (MPS II, Hunter syndrome, MIM:309900) is an X-linked, recessive genetic disorder which therefore primarily affects males. MPS II was first described in 1917, by Major Charles...
MPS IIIA - Sanfilippo syndrome A, organism-specific biosystem (from REACTOME)
MPS IIIA - Sanfilippo syndrome A, organism-specific biosystemMucopolysaccharidosis III (MPS III, Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837-838, 1963, no reference). Mucopolysaccharidosis IIIA (M...
MPS IIIB - Sanfilippo syndrome B, organism-specific biosystem (from REACTOME)
MPS IIIB - Sanfilippo syndrome B, organism-specific biosystemMucopolysaccharidosis III (Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837838, 1963, no reference). MPS IIIB (Mucopolysaccharidosis type II...
MPS IIIC - Sanfilippo syndrome C, organism-specific biosystem (from REACTOME)
MPS IIIC - Sanfilippo syndrome C, organism-specific biosystemMucopolysaccharidosis III (Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837838, 1963, no reference). Mucopolysaccharidosis type IIIC (MPS II...
MPS IIID - Sanfilippo syndrome D, organism-specific biosystem (from REACTOME)
MPS IIID - Sanfilippo syndrome D, organism-specific biosystemMucopolysaccharidosis III (Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837-838, 1963, no reference). Mucopolysaccharidosis type IIID (MPS I...
MPS IV - Morquio syndrome A, organism-specific biosystem (from REACTOME)
MPS IV - Morquio syndrome A, organism-specific biosystemMucopolysaccharidosis IV A (MPS IVA, MPS4A, Morquio's syndrome, Morquio's; MIM:253000) is a rare, autosomal recessive mucopolysaccharide storage disease, first described simultaneously in 1929 by L M...
MPS IV - Morquio syndrome B, organism-specific biosystem (from REACTOME)
MPS IV - Morquio syndrome B, organism-specific biosystemDefects in beta-galactosidase (GLB1; MIM:611458) can result in GM1 gangliosidosis (GM1; MIM:230500) (Nishimoto et al. 1991) (not described here), with several phenotypes indicating mental deteriorati...
MPS IX - Natowicz syndrome, organism-specific biosystem (from REACTOME)
MPS IX - Natowicz syndrome, organism-specific biosystemMucopolysaccharidosis type IX (MPS IX, Natowicz syndrome, Hyaluronidase deficiency, MIM:601492) is a rare lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum re...
MPS VI - Maroteaux-Lamy syndrome, organism-specific biosystem (from REACTOME)
MPS VI - Maroteaux-Lamy syndrome, organism-specific biosystemMucopolysaccharidosis type VI (MPS VI, Maroteaux-Lamy syndrome, polydystrophic dwarfism; MIM:253200) is an autosomal recessive lysosomal storage disorder caused by a deficiency in arylsulfatase B (AR...
MPS VII - Sly syndrome, organism-specific biosystem (from REACTOME)
MPS VII - Sly syndrome, organism-specific biosystemMucopolysaccharidosis type VII (MPS VII, Sly syndrome, beta-glucuronidase deficiency; MIM:253220) is an autosomal recessive lysosomal storage disease characterized by a deficiency of the enzyme beta-...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
Mucopolysaccharidoses, organism-specific biosystem (from REACTOME)
Mucopolysaccharidoses, organism-specific biosystemThe mucopolysaccharidoses (MPS) are a group of rare, inherited lysosomal storage disorders caused by deficiencies of enzymes catalyzing the stepwise degradation of glycosaminoglycans (GAGs, originall...
Osteopontin-mediated events, organism-specific biosystem (from Pathway Interaction Database)
Osteopontin-mediated events, organism-specific biosystem
Osteopontin-mediated events
Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem (from Pathway Interaction Database)
Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem
Paxillin-independent events mediated by a4b1 and a4b7
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
Shigellosis, organism-specific biosystem (from KEGG)
Shigellosis, organism-specific biosystemShigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestina...
TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...

General gene information

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Markers

STS-H03494 (e-PCR)
- UniSTS:34564

STS-N23307 (e-PCR)
- UniSTS:69894

Cd44 (e-PCR), detects polymorphism
- UniSTS:525578

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

GDB:185470 (e-PCR)
- UniSTS:155448

RH35975 (e-PCR)
- UniSTS:77632

G15910 (e-PCR)
- UniSTS:42305

D11S4589 (e-PCR)
- UniSTS:18756

RH69895 (e-PCR)
- UniSTS:24909

CD44_1447 (e-PCR)
- UniSTS:277075

PMC111028P1 (e-PCR)
- UniSTS:270201

G62926 (e-PCR)
- UniSTS:139901

D11S4430 (e-PCR)
- UniSTS:9858

PMC303366P9 (e-PCR)
- UniSTS:272516

D11S3129 (e-PCR)
- UniSTS:152220

SHGC-58498 (e-PCR)
- UniSTS:94370

RH36176 (e-PCR)
- UniSTS:21925

AFM283wh9 (e-PCR)
- UniSTS:80571

RH68898 (e-PCR)
- UniSTS:3025

G62000 (e-PCR)
- UniSTS:139219

RH103158 (e-PCR)
- UniSTS:97492

GDB:196637 (e-PCR)
- UniSTS:155877

CD44 (e-PCR), detects polymorphism
- UniSTS:47355

Genotypes

See CD44 SNP Geneview Report
See CD44 SNP Genotype Report
See CD44 SNP Variation Viewer Report

Homology

Homologs of the CD44 gene: The CD44 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
collagen binding	NAS Non-traceable Author Statement more info	PubMed
hyaluronic acid binding	IDA Inferred from Direct Assay more info	PubMed
hyaluronic acid binding	NAS Non-traceable Author Statement more info	PubMed
hyalurononglucosaminidase activity	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
Wnt receptor signaling pathway	IEA Inferred from Electronic Annotation more info
branching involved in prostate gland morphogenesis	IEA Inferred from Electronic Annotation more info
branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
carbohydrate metabolic process	TAS Traceable Author Statement more info
cartilage development	IEP Inferred from Expression Pattern more info	PubMed
cell-cell adhesion	NAS Non-traceable Author Statement more info	PubMed
cell-matrix adhesion	NAS Non-traceable Author Statement more info	PubMed
cellular response to fibroblast growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
glycosaminoglycan metabolic process	TAS Traceable Author Statement more info
hyaluronan catabolic process	IDA Inferred from Direct Assay more info	PubMed
hyaluronan catabolic process	TAS Traceable Author Statement more info
hyaluronan metabolic process	TAS Traceable Author Statement more info
interferon-gamma-mediated signaling pathway	TAS Traceable Author Statement more info
monocyte aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
positive regulation of heterotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of monocyte aggregation	IMP Inferred from Mutant Phenotype more info
positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
small molecule metabolic process	TAS Traceable Author Statement more info
wound healing involved in inflammatory response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
cell surface	IDA Inferred from Direct Assay more info	PubMed
external side of plasma membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	NAS Non-traceable Author Statement more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: CD44 antigen

Names: CD44 antigen; epican; Hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; heparan sulfate proteoglycan; cell surface glycoprotein CD44; extracellular matrix receptor III; chondroitin sulfate proteoglycan 8; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; homing function and Indian blood group system

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008937.1 RefSeqGene

Range

5001..98533

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000610.3 → NP_000601.3 CD44 antigen isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. It encodes the longest isoform (1).

Source sequence(s)

AK127622, AL832642, AY101192, BC004372, BF828674, BF872530, CD721908

Consensus CDS

CCDS7897.1

UniProtKB/Swiss-Prot

P16070

Conserved Domains (1) summary

cd03516
Location:26 – 170
Blast Score: 498

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001001389.1 → NP_001001389.1 CD44 antigen isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1.

Source sequence(s)

AK127622, AL832642, AY101192, BC004372, BF828674, CD721908

Consensus CDS

CCDS31455.1

UniProtKB/Swiss-Prot

P16070

Conserved Domains (1) summary

cd03516
Location:26 – 170
Blast Score: 496

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001001390.1 → NP_001001390.1 CD44 antigen isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as CD44R, lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AK127622, AL832642, AY101192, BG946113, CD721908

Consensus CDS

CCDS31456.1

UniProtKB/Swiss-Prot

P16070

Conserved Domains (1) summary

cd03516
Location:26 – 170
Blast Score: 493

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001001391.1 → NP_001001391.1 CD44 antigen isoform 4 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (4) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AK127622, AL832642, AY101192, CD721908

Consensus CDS

CCDS31457.1

UniProtKB/Swiss-Prot

P16070

Related

ENSP00000263398, OTTHUMP00000232487, ENST00000263398, OTTHUMT00000388924

Conserved Domains (1) summary

cd03516
Location:26 – 170
Blast Score: 496

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001001392.1 → NP_001001392.1 CD44 antigen isoform 5 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks multiple coding-exons compared to variant 1. The translation frame is changed. The resulting isoform (5), also known as CD44 isoform RC, has a distinct and shorter C-terminus, as compared to isoform 1.

Source sequence(s)

AK127622, AL832642, AY101192, CD721908, W47313

Consensus CDS

CCDS31458.1

UniProtKB/Swiss-Prot

P16070

Conserved Domains (1) summary

cl02612
Location:26 – 118
Blast Score: 227

Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...
NM_001202555.1 → NP_001189484.1 CD44 antigen isoform 6 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (6), also known as CD44R2, lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (6) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AL133330, AL832642, EF581837

Consensus CDS

CCDS55754.1

UniProtKB/Swiss-Prot

P16070

Conserved Domains (1) summary

cd03516
Location:26 – 170
Blast Score: 493

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001202556.1 → NP_001189485.1 CD44 antigen isoform 7 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (7) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AL133330, AL832642, FJ216964

Consensus CDS

CCDS55755.1

UniProtKB/Swiss-Prot

P16070

Conserved Domains (1) summary

cd03516
Location:26 – 170
Blast Score: 498

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001202557.1 → NP_001189486.1 CD44 antigen isoform 8 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (8), also known as Hermes, lacks multiple in-frame coding-exons and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (8) lacks an internal segment and has a shorter and distinct C-terminus, as compared to isoform 1.

Source sequence(s)

AL133330, AL832642, M25078

UniProtKB/Swiss-Prot

P16070

Related

ENSP00000398099, OTTHUMP00000232495, ENST00000442151, OTTHUMT00000388933

Conserved Domains (1) summary

cd03516
Location:26 – 170
Blast Score: 488

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p10 Primary Assembly

Range

35160417..35253949

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

34858894..34952423

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018922.1 Alternate CHM1_1.0

Range

35088995..35182543

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01060862.1 (47257..140786)	None
genomic	AL133330.14 (119473..183681)	None
genomic	AL136989.10 (101..5953)	None
genomic	AL356215.11 (101..23572)	None
genomic	AMYH01003489.1 (451384..544932)	None
genomic	CH471064.2	EAW68144.1
		EAW68145.1
		EAW68146.1
		EAW68147.1
		EAW68148.1
		EAW68149.1
		EAW68150.1
		EAW68151.1
		EAW68152.1
		EAW68153.1
		EAW68154.1
		EAW68155.1
genomic	HI519530.1	CBX54346.1
genomic	L05423.1	AAB13622.1
		AAB13623.1
genomic	L05424.1	AAB13624.1
		AAB13625.1
		AAB13626.1
		AAB13627.1
		AAB13628.1
genomic	S72928.1	AAB30429.1
mRNA	AB073901.1	None
mRNA	AF086543.1	None
mRNA	AF098641.1	AAC70782.1
mRNA	AJ251595.1	CAB61878.1
mRNA	AK123567.1	None
mRNA	AK127622.1	None
mRNA	AK129808.1	None
mRNA	AK290424.1	BAF83113.1
mRNA	AK297776.1	BAG60121.1
mRNA	AK304467.1	BAG65282.1
mRNA	AK307707.1	None
mRNA	AL832642.2	CAD89965.1
mRNA	AY101192.1	AAM50040.1
mRNA	AY101193.1	AAM50041.1
mRNA	BC004372.1	AAH04372.1
mRNA	BC052287.1	AAH52287.1
mRNA	BC067348.1	AAH67348.1
mRNA	BF828674.1	None
mRNA	BF872530.1	None
mRNA	BG946113.1	None
mRNA	CD721908.1	None
mRNA	D28447.1	BAA05813.1
mRNA	EF581837.1	ABQ59315.1
mRNA	FJ216964.1	ACI46596.1
mRNA	M24915.1	AAA35674.1
mRNA	M25078.1	AAA36138.1
mRNA	M59040.1	AAA51950.1
mRNA	M83324.1	None
mRNA	M83325.1	None
mRNA	M83326.1	None
mRNA	M83327.1	None
mRNA	M83328.1	None
mRNA	S66400.1	AAB27917.1
		AAB27918.2
		AAB27919.1
mRNA	S82326.1	AAD14389.1
mRNA	U40373.1	AAA82949.1
mRNA	W47313.1	None
mRNA	X55150.1	CAA38951.1
mRNA	X55938.1	CAA39404.1
mRNA	X56794.1	CAA40133.1
mRNA	X62739.1	CAA44602.1
mRNA	X66733.1	CAA47271.1