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KIF20B kinesin family member 20B [ Homo sapiens (human) ]

Gene ID: 9585, updated on 26-May-2016
Official Symbol
KIF20Bprovided by HGNC
Official Full Name
kinesin family member 20Bprovided by HGNC
Primary source
HGNC:HGNC:7212
See related
Ensembl:ENSG00000138182 HPRD:09268; MIM:605498; Vega:OTTHUMG00000018725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT90; MPP1; KRMP1; MPP-1; MPHOSPH1
Orthologs
Location:
10q23.31
Exon count:
33
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (89701590..89774943)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (91461264..91534700)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378421 Neighboring gene uncharacterized LOC105378420 Neighboring gene tigger transposable element derived 2 pseudogene Neighboring gene uncharacterized LOC105378423 Neighboring gene uncharacterized LOC105378424 Neighboring gene long intergenic non-protein coding RNA 865

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
NHGRI GWA Catalog
  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Gastric cancer network 1, organism-specific biosystem (from WikiPathways)
    Gastric cancer network 1, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Networks generated by Ingenuity Pathway Analysis.
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Kinesins, organism-specific biosystem (from REACTOME)
    Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp434B0435, DKFZp434P0810

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent microtubule motor activity, plus-end-directed IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
WW domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell cycle arrest NAS
Non-traceable Author Statement
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mitotic cytokinetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mitotic nuclear division NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
contractile ring IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
growth cone IEA
Inferred from Electronic Annotation
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
midbody ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
spindle midzone ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
kinesin-like protein KIF20B
Names
M-phase phosphoprotein 1
cancer/testis antigen 90
kinesin-related motor interacting with PIN1
mitotic kinesin-like protein
mitotic kinesin-related protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284259.1NP_001271188.1  kinesin-like protein KIF20B isoform 1

    See identical proteins and their annotated locations for NP_001271188.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB033337, AL137392, AY282406, AY282407, CB130618
    Consensus CDS
    CCDS60590.1
    UniProtKB/Swiss-Prot
    Q96Q89
    Related
    ENSP00000360793, OTTHUMP00000020075, ENST00000371728, OTTHUMT00000049330
    Conserved Domains (4) summary
    smart00129
    Location:60479
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1196
    Location:6291455
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19219
    Location:12681357
    DUF342; Protein of unknown function (DUF342)
    cd01368
    Location:57477
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
  2. NM_016195.3NP_057279.2  kinesin-like protein KIF20B isoform 2

    See identical proteins and their annotated locations for NP_057279.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to isoform 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AB033337, AL137392, AY282406, AY282407, CB130618
    Consensus CDS
    CCDS7407.1
    UniProtKB/Swiss-Prot
    Q96Q89
    Related
    ENSP00000260753, OTTHUMP00000020073, ENST00000260753, OTTHUMT00000049328
    Conserved Domains (4) summary
    smart00129
    Location:60479
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1196
    Location:6731392
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19219
    Location:12281317
    DUF342; Protein of unknown function (DUF342)
    cd01368
    Location:57477
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    89701590..89774943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    91743446..91816800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)