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    CD40 CD40 molecule, TNF receptor superfamily member 5 [ Homo sapiens (human) ]

    Gene ID: 958, updated on 22-May-2013
    Official Symbol
    CD40provided by HGNC
    Official Full Name
    CD40 molecule, TNF receptor superfamily member 5provided by HGNC
    Primary source
    HGNC:11919
    See related
    Ensembl:ENSG00000101017; HPRD:00178; MIM:109535; Vega:OTTHUMG00000033053
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p50; Bp50; CDW40; TNFRSF5
    Summary
    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
    Location :
    20q12-q13.2
    Sequence :
    Chromosome: 20; NC_000020.10 (44746906..44758384)
    See CD40 in Epigenomics, MapViewer

    Chromosome 20 - NC_000020.10Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 5 Neighboring gene ribosomal protein L13 pseudogene 2 Neighboring gene cadherin 22, type 2 Neighboring gene solute carrier family 35, member C2

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The binding of HIV-1 gp120 to CD4 molecules on T cells interrupts the sequential cascade of intercellular interactions involving antigen/MHC class II-TCR/CD4, CD40L-CD40, and B71-CD28 PubMed
    env Upregulation of apoptosis genes such as NCK-associated protein 1, PTB domain adaptor protein CED-6, and TNF receptor superfamily 5 are induced by HIV-1 gp120 in human neurons PubMed
    env HIV-1 gp120-induced reduction of IL-12 parallels IL-10 induction and inhibits translocation of CD40 to the surface of monocytes PubMed
    Gag, Pr55 gag CD40L expression on the surface of virus-like particles (VLPs) is to target HIV-1 Gag antigens to the CD40 receptor on dendritic cell (DCs) PubMed
    Tat, p14 tat Recombinant CD40L synergizes with HIV-1 Tat to increase TNF-alpha release from primary human monocytes and microglia in an NF-kappaB-dependent manner. This synergism is attributed to a Tat-mediated up-regulation of CD40. PubMed
    tat HIV-1 Tat upregulates the expression of MHC and co-stimulatory molecules CD40, CD80, CD83 and CD86 in monocyte-derived dendritic cells, thereby driving T cell-mediated immune responses PubMed
    Vpr, p15 vpr HIV-1 Vpr downregulates the expression of several immunologically important molecules including CD40, CD80, CD83, and CD86 co-stimulatory molecules on monocyte-derived macrophage (MDM) and monocyte-derived dendritic cells (MDDC) PubMed
    Vpu, p16 vpu HIV-1 Vpu upregulates CD40 expression, which enhances efficient expression of VCAM-1 in endothelial cells PubMed
    matrix gag Treatment of human PBMCs with HIV-1 MA upregulates the expression of MCP-1, ICAM-1, CD40, CD86 and CD36 and downregulates the expression of nuclear receptors FXR and PPARgamma PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001241.1 NP_066961.2 TRAF2    BIND  PubMed CD40 interacts with TRAF2. 
    NP_001241.1 NP_003291.2 TRAF3    BIND  PubMed CD40 interacts with TRAF3. 
    NP_001241.1 NP_663777.1 TRAF3    BIND  PubMed CD40 interacts with TRAF3. 
    P25942 Q13490 BIRC2    HPRD  PubMed  
    P25942 Q13489 BIRC3    HPRD  PubMed  
    P25942 Q03135 CAV1    HPRD  PubMed  
    P25942 P22681 CBL    HPRD  PubMed  
    P25942 P29965 CD40LG    HPRD  PubMed  
    P25942 P34932 HSPA4    HPRD  PubMed  
    P25942 P11142 HSPA8    HPRD  PubMed  
    P25942 P24394 IL4R    HPRD  PubMed  
    P25942 P52333 JAK3    HPRD  PubMed  
    P25942 P41279 MAP3K8    HPRD  PubMed  
    P25942 P11836 MS4A1    HPRD  PubMed  
    P25942 Q92636 NSMAF    HPRD  PubMed  
    P25942 P27986 PIK3R1    HPRD  PubMed  
    P25942 O43353 RIPK2    HPRD  PubMed  
    P25942 O95551 TDP2    HPRD  PubMed  
    P25942 Q13077 TRAF1    HPRD  PubMed  
    P25942 Q12933 TRAF2    HPRD  PubMed  
    P25942 Q13114 TRAF3    HPRD  PubMed  
    P25942 O43734 TRAF3IP2    HPRD  PubMed  
    P25942 O00463 TRAF5    HPRD  PubMed  
    P25942 Q9Y4K3 TRAF6    HPRD  PubMed  
    P25942 P13010 XRCC5    HPRD  PubMed  
    P25942 P12956 XRCC6    HPRD  PubMed  
    BioGRID:107396 BioGRID:106826 BIRC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107396 BioGRID:107262 CALR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107396 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107396 BioGRID:119497 CDC40    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107396 BioGRID:108020 DDX3X    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107396 BioGRID:116704 ERP44    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107396 BioGRID:108399 FBL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107396 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107396 BioGRID:109780 IL4R    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107396 BioGRID:107719 MAP3K8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107396 BioGRID:107369 MS4A1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107396 BioGRID:116691 NCOA6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107396 BioGRID:111308 PIK3CA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107396 BioGRID:111433 POLR2H    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107396 BioGRID:111917 RFC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107396 BioGRID:114300 RIPK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107396 BioGRID:122736 RNF219    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107396 BioGRID:112344 SGK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107396 BioGRID:127176 SLC30A7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107396 BioGRID:113652 SLC39A7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107396 BioGRID:113188 SUMO1    BioGRID  PubMed Two-hybrid 
    BioGRID:107396 BioGRID:115328 TANK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107396 BioGRID:119615 TDP2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107396 BioGRID:113037 TRAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107396 BioGRID:113038 TRAF2    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; FRET; Reconstituted Complex; Two-hybrid 
    BioGRID:107396 BioGRID:113039 TRAF3    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:107396 BioGRID:115979 TRAF3IP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107396 BioGRID:114979 TRAF4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107396 BioGRID:113040 TRAF5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107396 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; FRET; Reconstituted Complex 
    BioGRID:107396 BioGRID:113146 TXN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107396 BioGRID:121217 UGGT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107396 BioGRID:115283 USP15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107396 BioGRID:113353 XRCC5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107396 BioGRID:108822 XRCC6    BioGRID  PubMed Reconstituted Complex 
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Allograft rejection, organism-specific biosystem (from KEGG)
      Allograft rejection, organism-specific biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Allograft rejection, conserved biosystem (from KEGG)
      Allograft rejection, conserved biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Asthma, organism-specific biosystem (from KEGG)
      Asthma, organism-specific biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
    • Asthma, conserved biosystem (from KEGG)
      Asthma, conserved biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
    • Autoimmune thyroid disease, organism-specific biosystem (from KEGG)
      Autoimmune thyroid disease, organism-specific biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • Autoimmune thyroid disease, conserved biosystem (from KEGG)
      Autoimmune thyroid disease, conserved biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • CD40/CD40L signaling, organism-specific biosystem (from Pathway Interaction Database)
      CD40/CD40L signaling, organism-specific biosystem
      CD40/CD40L signaling
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Inflammatory Response Pathway, organism-specific biosystem (from WikiPathways)
      Inflammatory Response Pathway, organism-specific biosystem
      Inflammatory Response Pathway
    • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
      Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
      Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NLR proteins, organism-specific biosystem (from WikiPathways)
      NLR proteins, organism-specific biosystemMammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen-associated-molecular- patterns (PAMP...
    • Primary immunodeficiency, organism-specific biosystem (from KEGG)
      Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • Primary immunodeficiency, conserved biosystem (from KEGG)
      Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
      Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Systemic lupus erythematosus, conserved biosystem (from KEGG)
      Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
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    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

    Markers

    Homology

    Clone Names

    • MGC9013

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transducer activity TAS
    Traceable Author Statement
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
     
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    immune response-regulating cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    platelet activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of Cdc42 GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB cascade IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
     
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
     
    positive regulation of Rac GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
     
    positive regulation of endothelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of isotype switching to IgG isotypes IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase C signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
     
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
     
    positive regulation of tyrosine phosphorylation of Stat1 protein IMP
    Inferred from Mutant Phenotype
    more info
     
    protein complex assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    regulation of immunoglobulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    CD40 receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    tumor necrosis factor receptor superfamily member 5
    Names
    tumor necrosis factor receptor superfamily member 5
    CD40L receptor
    CD40 type II isoform
    B cell-associated molecule
    B cell surface antigen CD40
    B-cell surface antigen CD40
    CD40 antigen (TNF receptor superfamily member 5)
    tumor necrosis factor receptor superfamily, member 5
    nerve growth factor receptor-related B-lymphocyte activation molecule

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007279.1 RefSeqGene

      Range
      5001..16479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_40

    mRNA and Protein(s)

    1. NM_001250.4NP_001241.1  tumor necrosis factor receptor superfamily member 5 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL035662, BC012419, BM761221
      Consensus CDS
      CCDS13393.1
      UniProtKB/Swiss-Prot
      P25942
      Related
      ENSP00000361359, OTTHUMP00000031699, ENST00000372285, OTTHUMT00000080376
      Conserved Domains (2) summary
      cd00185
      Location:26123
      Blast Score: 197
      TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
      cl12111
      Location:125187
      Blast Score: 96
      TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
    2. NM_152854.2NP_690593.1  tumor necrosis factor receptor superfamily member 5 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a coding segment, which leads to a translation frame shift, compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AJ300189, AL035662, BC012419, BM761221
      Consensus CDS
      CCDS13394.1
      UniProtKB/Swiss-Prot
      P25942
      Related
      ENSP00000361350, OTTHUMP00000031700, ENST00000372276, OTTHUMT00000080377
      Conserved Domains (2) summary
      cd00185
      Location:26123
      Blast Score: 188
      TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
      smart00208
      Location:105143
      Blast Score: 85
      TNFR; Tumor necrosis factor receptor / nerve growth factor receptor repeats.

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000020.10 Reference GRCh37.p10 Primary Assembly

      Range
      44746906..44758384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000152.1 Alternate HuRef

      Range
      41488189..41499674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018931.1 Alternate CHM1_1.0

      Range
      44717424..44729005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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