CDC42BPB CDC42 binding protein kinase beta (DMPK-like) [Homo sapiens] - Gene

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Summary

Official Symbol: CDC42BPBprovided by HGNC
Official Full Name: CDC42 binding protein kinase beta (DMPK-like)provided by HGNC
Primary source: HGNC:1738
See related: Ensembl:ENSG00000198752; HPRD:08516; MIM:614062; Vega:OTTHUMG00000171898
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MRCKB; FLJ37601; FLJ44730; KIAA1124; DKFZp686H1431
Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 14q32.3

Sequence :: Chromosome: 14; NC_000014.8 (103398716..103523742, complement)

See CDC42BPB in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results provide further validation for MRCK involvement in regulation of cancer cell invasion.
Title: Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.
Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration.
Title: Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration.
Q-PCR results demonstrated VH2 genes were overexpressed in ankylosing spondylitis patients. The sequence analysis revealed the majority of them contained CDC42 binding protein kinase Beta (CDC42 BPB) genes.
Title: Overexpression and unique rearrangement of VH2 transcripts in immunoglobulin variable heavy chain genes in ankylosing spondylitis patients.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
analysis of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta
Title: Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility.

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:114947	BioGRID:120586	BRIX1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114947	BioGRID:107433	CDC42	BioGRID	PubMed	Two-hybrid
BioGRID:114947	BioGRID:125564	DCD	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114947	BioGRID:111593	MAP2K5	BioGRID	PubMed	Two-hybrid
BioGRID:114947	BioGRID:114274	RIPK1	BioGRID	PubMed	Two-hybrid
BioGRID:114947	BioGRID:112042	RPL3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114947	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
ATP binding	ISS Inferred from Sequence or Structural Similarity more info
Rho GTPase binding	IEA Inferred from Electronic Annotation more info
magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein kinase activity	TAS Traceable Author Statement more info	PubMed
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
small GTPase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
actin cytoskeleton reorganization	ISS Inferred from Sequence or Structural Similarity more info
actomyosin structure organization	IMP Inferred from Mutant Phenotype more info	PubMed
cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
establishment or maintenance of cell polarity	TAS Traceable Author Statement more info	PubMed
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
protein phosphorylation	IEA Inferred from Electronic Annotation more info
protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
protein phosphorylation	TAS Traceable Author Statement more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
actomyosin	IDA Inferred from Direct Assay more info	PubMed
cell leading edge	ISS Inferred from Sequence or Structural Similarity more info
cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	TAS Traceable Author Statement more info	PubMed
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: serine/threonine-protein kinase MRCK beta

Names: serine/threonine-protein kinase MRCK beta; MRCK beta; CDC42BP-beta; DMPK-like beta; myotonic dystrophy protein kinase-like beta; CDC42-binding protein kinase beta (DMPK-like); myotonic dystrophy kinase-related CDC42-binding kinase beta

NP_006026.3

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006035.3 → NP_006026.3 serine/threonine-protein kinase MRCK beta

Status: REVIEWED

Source sequence(s)

AB032950, AF128625, AL117209, BC048261

Consensus CDS

CCDS9978.1

UniProtKB/TrEMBL

Q86XZ8

UniProtKB/Swiss-Prot

Q9Y5S2

Related

ENSP00000355237, OTTHUMP00000247081, ENST00000361246, OTTHUMT00000415711

Conserved Domains (9) summary

cd00029
Location:1026 – 1075
Blast Score: 157

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00132
Location:1581 – 1608
Blast Score: 104

CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

pfam08826
Location:878 – 919
Blast Score: 154

DMPK_coil; DMPK coiled coil domain like

TIGR02168
Location:437 – 828
Blast Score: 231

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd05597
Location:74 – 404
Blast Score: 1908

STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase-like Protein Serine/Threonine Kinases

smart00220
Location:76 – 342
Blast Score: 731

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam09304
Location:539 – 639
Blast Score: 90

Cortex-I_coil; Cortexillin I, coiled coil

cl00273
Location:1095 – 1216
Blast Score: 407

PH-like; Pleckstrin homology-like domain

cl02434
Location:1245 – 1510
Blast Score: 671

CNH; CNH domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

103398716..103523742, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

83573751..83698598, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL117209.7 (148592..157603)	None
genomic	AL133455.4 (18990..135060)	None
genomic	CH471061.1	EAW81800.1
		EAW81801.1
genomic	DQ355971.1	ABC67469.1
mRNA	AB032950.3	BAA86438.2
mRNA	AF128625.1	AAD37506.1
mRNA	AK094920.1	None
mRNA	AK126684.1	None
mRNA	BC047871.1	AAH47871.1
mRNA	BC048261.1	AAH48261.1
mRNA	BC155541.1	AAI55542.1
mRNA	BX248752.1	CAD66559.1
mRNA	BX647753.1	None
other-genetic	BC156936.1	AAI56937.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q86TR8	GenPept	UniProtKB/TrEMBL:Q86TR8
Q86XZ8	GenPept	UniProtKB/TrEMBL:Q86XZ8
Q9Y5S2.2	GenPept	UniProtKB/Swiss-Prot:Q9Y5S2