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BCAR1 breast cancer anti-estrogen resistance 1 [ Homo sapiens (human) ]

Gene ID: 9564, updated on 19-Apr-2014
Official Symbol
BCAR1provided by HGNC
Official Full Name
breast cancer anti-estrogen resistance 1provided by HGNC
Primary source
HGNC:971
Locus tag
hCG_1980470
See related
Ensembl:ENSG00000050820; HPRD:04248; MIM:602941; Vega:OTTHUMG00000137604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAS; CAS1; CASS1; CRKAS; P130Cas
Summary
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]
Location :
16q23.1
Sequence :
Chromosome: 16; NC_000016.10 (75229030..75268053, complement)
See BCAR1 in Epigenomics, MapViewer

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506281 Neighboring gene chymotrypsinogen B1 Neighboring gene craniofacial development protein 1 Neighboring gene uncharacterized LOC101928178 Neighboring gene transmembrane protein 170A

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of breast cancer anti-estrogen resistance 1 (BCAR1) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat HIV-1 Tat enhances the tyrosine phosphorylation of p130Cas, an effect linked to Tat-induced angiogenesis and AIDS-related Kaposi's sarcoma PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G-protein coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
G-protein coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
T cell receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
actin filament organization IDA
Inferred from Direct Assay
more info
PubMed 
antigen receptor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
blood coagulation TAS
Traceable Author Statement
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
 
cell division NAS
Non-traceable Author Statement
more info
PubMed 
cell migration IDA
Inferred from Direct Assay
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cellular response to hepatocyte growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
 
epidermal growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
hepatocyte growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 
insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
neurotrophin TRK receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
platelet-derived growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
 
regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
regulation of cell growth TAS
Traceable Author Statement
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
breast cancer anti-estrogen resistance protein 1
Names
breast cancer anti-estrogen resistance protein 1
Crk-associated substrate p130Cas
Cas scaffolding protein family member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170714.1NP_001164185.1  breast cancer anti-estrogen resistance protein 1 isoform 1

    See proteins identical to NP_001164185.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB040024, AK293808, AK295809, BU730553
    Consensus CDS
    CCDS54040.1
    UniProtKB/Swiss-Prot
    P56945
    Related
    ENSP00000391669, OTTHUMP00000255558, ENST00000418647, OTTHUMT00000434666
    Conserved Domains (3) summary
    cd11552
    Location:500656
    Blast Score: 557
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd11569
    Location:781913
    Blast Score: 724
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd12001
    Location:51116
    Blast Score: 359
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
  2. NM_001170715.1NP_001164186.1  breast cancer anti-estrogen resistance protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AB040024, AK124815, BU730553
    Consensus CDS
    CCDS54043.1
    UniProtKB/Swiss-Prot
    P56945
    Related
    ENSP00000377074, OTTHUMP00000174941, ENST00000393422, OTTHUMT00000269016
    Conserved Domains (3) summary
    cd11552
    Location:472628
    Blast Score: 557
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd11569
    Location:753885
    Blast Score: 722
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd12001
    Location:2388
    Blast Score: 359
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
  3. NM_001170716.1NP_001164187.1  breast cancer anti-estrogen resistance protein 1 isoform 3

    See proteins identical to NP_001164187.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (3) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AB040024, AK295809, BU730553, DC317947
    Consensus CDS
    CCDS54042.1
    UniProtKB/Swiss-Prot
    P56945
    Related
    ENSP00000392708, OTTHUMP00000255559, ENST00000420641, OTTHUMT00000434667
    Conserved Domains (3) summary
    cd11552
    Location:472628
    Blast Score: 555
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd11569
    Location:753885
    Blast Score: 722
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd12001
    Location:2388
    Blast Score: 359
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
  4. NM_001170717.1NP_001164188.1  breast cancer anti-estrogen resistance protein 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 5' sequence and an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (4) is shorter, and has a different N-terminus and an additional segment in the middle region, as compared to isoform 1.
    Source sequence(s)
    AB040024, AY545071, BU730553, DA418642
    Consensus CDS
    CCDS54038.1
    UniProtKB/Swiss-Prot
    P56945
    Related
    ENSP00000377072, OTTHUMP00000255594, ENST00000393420, OTTHUMT00000434756
    Conserved Domains (3) summary
    cd11552
    Location:472628
    Blast Score: 555
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd11569
    Location:753885
    Blast Score: 722
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd12001
    Location:470
    Blast Score: 363
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
  5. NM_001170718.1NP_001164189.1  breast cancer anti-estrogen resistance protein 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon in the 5' region, resulting in an alternate AUG start codon, as compared to variant 1. The resulting isoform (5) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AB040024, AK027608, AK295809, BU730553
    Consensus CDS
    CCDS54041.1
    UniProtKB/Swiss-Prot
    P56945
    Related
    ENSP00000443841, OTTHUMP00000255557, ENST00000538440, OTTHUMT00000434665
    Conserved Domains (3) summary
    cd11552
    Location:454610
    Blast Score: 555
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd11569
    Location:735867
    Blast Score: 721
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd12001
    Location:570
    Blast Score: 359
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
  6. NM_001170719.1NP_001164190.1  breast cancer anti-estrogen resistance protein 1 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (7) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AB040024, AK295809, BU730553, DC310094
    Consensus CDS
    CCDS54037.1
    UniProtKB/Swiss-Prot
    P56945
    Related
    ENSP00000440415, OTTHUMP00000255593, ENST00000542031, OTTHUMT00000434755
    Conserved Domains (3) summary
    cd11552
    Location:452608
    Blast Score: 555
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd11569
    Location:733865
    Blast Score: 721
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd12001
    Location:368
    Blast Score: 359
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
  7. NM_001170720.1NP_001164191.1  breast cancer anti-estrogen resistance protein 1 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has an alternate internal sequence, as compared to variant 1. The resulting isoform (8) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AB040024, AK302617, BU730553
    Consensus CDS
    CCDS54039.1
    UniProtKB/Swiss-Prot
    P56945
    Related
    ENSP00000440370, OTTHUMP00000255592, ENST00000535626, OTTHUMT00000434754
    Conserved Domains (3) summary
    cd11569
    Location:587719
    Blast Score: 720
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cl07433
    Location:306462
    Blast Score: 550
    Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
    cl17036
    Location:564
    Blast Score: 326
    SH3; Src Homology 3 domain superfamily
  8. NM_001170721.1NP_001164192.1  breast cancer anti-estrogen resistance protein 1 isoform 9

    See proteins identical to NP_001164192.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (9) is much shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AB040024, AC009078, AK124844, BU730553
    UniProtKB/TrEMBL
    B3KWE2
    UniProtKB/Swiss-Prot
    P56945
    Conserved Domains (2) summary
    cd11569
    Location:525657
    Blast Score: 716
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cl07433
    Location:244400
    Blast Score: 547
    Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
  9. NM_014567.3NP_055382.2  breast cancer anti-estrogen resistance protein 1 isoform 6

    See proteins identical to NP_055382.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (6) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AB040024, AK295809, AK314722, BU730553
    Consensus CDS
    CCDS10915.1
    UniProtKB/TrEMBL
    B2RBL9
    UniProtKB/Swiss-Prot
    P56945
    Related
    ENSP00000162330, OTTHUMP00000174942, ENST00000162330, OTTHUMT00000269017
    Conserved Domains (3) summary
    cd11552
    Location:454610
    Blast Score: 555
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd11569
    Location:735867
    Blast Score: 721
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd12001
    Location:470
    Blast Score: 363
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10

    Range
    75229030..75268053, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721349.1XP_006721412.1  

    Conserved Domains (4) summary
    cd11569
    Location:688820
    Blast Score: 720
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cl07433
    Location:407563
    Blast Score: 553
    Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
    cd12001
    Location:51116
    Blast Score: 359
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
    pfam15133
    Location:164299
    Blast Score: 95
    DUF4569; Domain of unknown function (DUF4569)
  2. XM_006721348.1XP_006721411.1  

    See proteins identical to XP_006721411.1

    Conserved Domains (3) summary
    cd11552
    Location:500656
    Blast Score: 557
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd11569
    Location:781913
    Blast Score: 724
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd12001
    Location:51116
    Blast Score: 359
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
  3. XM_005256258.2XP_005256315.1  

    Conserved Domains (3) summary
    cd11552
    Location:480636
    Blast Score: 557
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd11569
    Location:761893
    Blast Score: 724
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd12001
    Location:3196
    Blast Score: 359
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
  4. XM_005256259.2XP_005256316.1  

    Conserved Domains (3) summary
    cd11552
    Location:454610
    Blast Score: 555
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd11569
    Location:735867
    Blast Score: 721
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd12001
    Location:570
    Blast Score: 359
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
  5. XM_005256260.2XP_005256317.1  

    UniProtKB/TrEMBL
    F5H855
    Conserved Domains (3) summary
    cd11552
    Location:425581
    Blast Score: 555
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd11569
    Location:706838
    Blast Score: 721
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cl17036
    Location:141
    Blast Score: 231
    SH3; Src Homology 3 domain superfamily

Alternate HuRef

Genomic

  1. AC_000148.1 Alternate HuRef

    Range
    61013718..61052474, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    76675047..76714069, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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