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BCAR1 breast cancer anti-estrogen resistance 1 [ Homo sapiens (human) ]

Gene ID: 9564, updated on 18-May-2013

Summary

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Official Symbol: BCAR1provided by HGNC
Official Full Name: breast cancer anti-estrogen resistance 1provided by HGNC
Primary source: HGNC:971
Locus tag: hCG_1980470
See related: Ensembl:ENSG00000050820; HPRD:04248; MIM:602941; Vega:OTTHUMG00000137604
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAS; CAS1; CASS1; CRKAS; P130Cas
Summary: BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]

Genomic context

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Location :: 16q23.1

Sequence :: Chromosome: 16; NC_000016.9 (75262928..75301951, complement)

See BCAR1 in Epigenomics, MapViewer

Chromosome 16 - NC_000016.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The aim of this study is to evaluate the role of p130cas, E-cadherin, and beta-catenin expression in patients with non-small cell lung cancer.
Title: Expression of p130cas, E-cadherin and β-catenin and their correlation with clinicopathological parameters in non-small cell lung cancer: p130cas over-expression predicts poor prognosis.
BCAR3 expression may regulate Src signaling in a BCAR3-p130(cas) complex-dependent fashion by altering the ability of the Src SH3 domain to bind the p130(cas) SBD
Title: Breast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas).
Study shows that BCAR4 expression identifies a subgroup of ER-positive breast cancer patients without overexpression of ERBB2 who have a poor outcome and might benefit from combined ERBB2-targeted and antioestrogen therapy.
Title: BCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinib.
BCAR1 is an independent predictor of recurrence following radical prostatectomy for "low risk" prostate cancer.
Title: BCAR1 expression improves prediction of biochemical reccurence after radical prostatectomy.
Ezrin and BCAR1/p130Cas mediate breast cancer growth as 3-D spheroids
Title: Ezrin and BCAR1/p130Cas mediate breast cancer growth as 3-D spheroids.
These results indicate a role for NRP1 and NRP1 glycosylation in mediating PDGF-induced VSMC migration, possibly by acting as a co-receptor for PDGFRalpha and via selective mobilization of a novel p130Cas tyrosine phosphorylation pathway.
Title: Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas.
Overexpression of BCAR1 is a predictor of poor prognosis in non-small-cell lung cancer and plays important carcinogenic roles in carcinogenesis.
Title: BCAR1 protein plays important roles in carcinogenesis and predicts poor prognosis in non-small-cell lung cancer.
Zyxin phenotype is mediated by partners alpha-actinin and p130Cas and ensures that motile cells in a three-dimensional matrix explore the largest space possible in minimum time.
Title: Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners.
Data show that phosphorylation of Src family kinases and the adaptor protein p130CAS, resulting in actin recruitment and CD36 clustering by 50-60% of adherent beads.
Title: Plasmodium falciparum-induced CD36 clustering rapidly strengthens cytoadherence via p130CAS-mediated actin cytoskeletal rearrangement.
These findings reveal an important role of CAS Y12 phosphorylation in the regulation of focal adhesion assembly, cell migration, and invasiveness of Src-transformed cells.
Title: Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness.

Submit: New GeneRIF Correction See all (57)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Tat, p14	tat	HIV-1 Tat enhances the tyrosine phosphorylation of p130Cas, an effect linked to Tat-induced angiogenesis and AIDS-related Kaposi's sarcoma	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_055382.2	NP_722560.1	PTK2	BIND	PubMed	CAS interacts with FAK. This interaction was modeled on a demonstrated interaction between human CAS and mouse FAK.
NP_055382.2	NP_005408.1	SRC	BIND	PubMed	c-Src interacts with CAS.
P56945	P00519	ABL1	HPRD	PubMed
P56945	Ajuba	AJUBA	HPRD	PubMed
P56945	RICS	ARHGAP32	HPRD	PubMed
P56945	P42574	CASP3	HPRD	PubMed
P56945	Q9Y5K6	CD2AP	HPRD	PubMed
P56945	P46108	CRK	HPRD	PubMed
P56945	P46109	CRKL	HPRD	PubMed
P56945	Q6UVK1	CSPG4	HPRD	PubMed
P56945	Q14185	DOCK1	HPRD	PubMed
P56945	Q14209	E2F2	HPRD	PubMed
P56945	O43281	EFS	HPRD	PubMed
P56945	P03372	ESR1	HPRD	PubMed
P56945	P07332	FES	HPRD	PubMed
P56945	Q9H0Q3	FXYD6	HPRD	PubMed
P56945	O15117	FYB	HPRD	PubMed
P56945	P06241	FYN	HPRD	PubMed
P56945	P62993	GRB2	HPRD	PubMed
P56945	P06396	GSN	HPRD	PubMed
P56945	P08631	HCK	HPRD	PubMed
P56945	P11021	HSPA5	HPRD	PubMed
P56945	SHIP2	INPPL1	HPRD	PubMed
P56945	P06239	LCK	HPRD	PubMed
P56945	P07948	LYN	HPRD	PubMed
P56945	P16333	NCK1	HPRD	PubMed
P56945	Q14511	NEDD9	HPRD	PubMed
P56945	O15259	NPHP1	HPRD	PubMed
P56945	P27986	PIK3R1	HPRD	PubMed
P56945	P98161	PKD1	HPRD	PubMed
P56945	O14495	PPAP2B	HPRD	PubMed
P56945	Protein phosphatase 1, regulatory subunit 15A	PPP1R15A	HPRD	PubMed
P56945	Q05397	PTK2	HPRD	PubMed
P56945	Q14289	PTK2B	HPRD	PubMed
P56945	P18031	PTPN1	HPRD	PubMed
P56945	Q05209	PTPN12	HPRD	PubMed
P56945	P18433	PTPRA	HPRD	PubMed
P56945	P10586	PTPRF	HPRD	PubMed
P56945	Protein tyrosine phosphatase receptor type H	PTPRH	HPRD	PubMed
P56945	P49023	PXN	HPRD	PubMed
P56945	Q13905	RAPGEF1	HPRD	PubMed
P56945	Q9BRG2	SH2D3A	HPRD	PubMed
P56945	Q8N5H7	SH2D3C	HPRD	PubMed
P56945	Q96B97	SH3KBP1	HPRD	PubMed
P56945	P12931	SRC	HPRD	PubMed
P56945	Q9C0H9	SRCIN1	HPRD	PubMed
P56945	Q15654	TRIP6	HPRD	PubMed
P56945	P68366	TUBA4A	HPRD	PubMed
P56945	Q9H270	VPS11	HPRD	PubMed
P56945	P63104	YWHAZ	HPRD	PubMed
BioGRID:114934	BioGRID:106543	ABL1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:114934	BioGRID:115091	ARHGAP32	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114934	BioGRID:119614	ARMCX3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114934	BioGRID:114000	BCAR3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:107128	BMX	BioGRID	PubMed	Protein-peptide
BioGRID:114934	BioGRID:107315	CBL	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:117140	CD2AP	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114934	BioGRID:107433	CDC42	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:107788	CRK	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Protein-peptide; Reconstituted Complex
BioGRID:114934	BioGRID:107789	CRKL	BioGRID	PubMed	Affinity Capture-Western; Far Western; Protein-peptide
BioGRID:114934	BioGRID:108128	DOCK1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114934	BioGRID:108202	E2F2	BioGRID	PubMed	Two-hybrid
BioGRID:114934	BioGRID:115567	EFS	BioGRID	PubMed	Two-hybrid
BioGRID:114934	BioGRID:118965	EPN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114934	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:108533	FES	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:114934	BioGRID:119799	FXYD6	BioGRID	PubMed	Two-hybrid
BioGRID:114934	BioGRID:108810	FYN	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114934	BioGRID:119443	GMPR2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114934	BioGRID:109142	GRB2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114934	BioGRID:109305	HCK	BioGRID	PubMed	Reconstituted Complex
BioGRID:114934	BioGRID:109541	HSPA5	BioGRID	PubMed	Two-hybrid
BioGRID:114934	BioGRID:115780	HYOU1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114934	BioGRID:109624	ID2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:109848	INPPL1	BioGRID	PubMed	Affinity Capture-Western; Far Western; Reconstituted Complex
BioGRID:114934	BioGRID:109891	ITGAV	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:122019	KIF13A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114934	BioGRID:110124	LCK	BioGRID	PubMed	Reconstituted Complex
BioGRID:114934	BioGRID:110245	LYN	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:111585	MAPK8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:110466	MMP14	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:110770	NCK1	BioGRID	PubMed	Affinity Capture-Western; Protein-peptide
BioGRID:114934	BioGRID:110816	NEDD9	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:110927	NPHP1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114934	BioGRID:111313	PIK3R1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114934	BioGRID:117172	PPP1R15A	BioGRID	PubMed	Two-hybrid
BioGRID:114934	BioGRID:111719	PTK2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114934	BioGRID:108480	PTK2B	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114934	BioGRID:111736	PTPN1	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:114934	BioGRID:111745	PTPN11	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:111746	PTPN12	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:114934	BioGRID:111758	PTPRH	BioGRID	PubMed	Reconstituted Complex
BioGRID:114934	BioGRID:111787	PXN	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:111837	RAN	BioGRID	PubMed	Two-hybrid
BioGRID:114934	BioGRID:109146	RAPGEF1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114934	BioGRID:109072	SFN	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114934	BioGRID:115356	SH2D3A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:115355	SH2D3C	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:119029	SH3KBP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:112592	SRC	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114934	BioGRID:123275	SRCIN1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:114934	BioGRID:115485	TNK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:112999	TNS1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:113056	TRIP6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:122505	TSEN34	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114934	BioGRID:204372	Tuba1a	BioGRID	PubMed	Two-hybrid
BioGRID:114934	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114934	BioGRID:125434	UHRF2	BioGRID	PubMed	Far Western
BioGRID:114934	BioGRID:113257	VCL	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114934	BioGRID:120930	VPS11	BioGRID	PubMed	Two-hybrid
BioGRID:114934	BioGRID:113363	YWHAE	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114934	BioGRID:113366	YWHAZ	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114934	BioGRID:113569	ZYX	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
CDC42 signaling events, organism-specific biosystem
CDC42 signaling events
CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
CXCR4-mediated signaling events, organism-specific biosystem
CXCR4-mediated signaling events
Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Downstream signal transduction, organism-specific biosystem (from REACTOME)
Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
EPHA2 forward signaling, organism-specific biosystem (from Pathway Interaction Database)
EPHA2 forward signaling, organism-specific biosystem
EPHA2 forward signaling
Endothelins, organism-specific biosystem (from Pathway Interaction Database)
Endothelins, organism-specific biosystem
Endothelins
Focal Adhesion, organism-specific biosystem (from WikiPathways)
Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, organism-specific biosystem (from KEGG)
Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, conserved biosystem (from KEGG)
Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
IGF1 pathway, organism-specific biosystem (from Pathway Interaction Database)
IGF1 pathway, organism-specific biosystem
IGF1 pathway
Integrin alphaIIb beta3 signaling, organism-specific biosystem (from REACTOME)
Integrin alphaIIb beta3 signaling, organism-specific biosystemAt the sites of vascular injury bioactive molecules such as thrombin, ADP, collagen, fibrinogen and thrombospondin are generated, secreted or exposed. These stimuli activate platelets, converting the...
Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
Integrins in angiogenesis, organism-specific biosystem
Integrins in angiogenesis
LPA receptor mediated events, organism-specific biosystem (from Pathway Interaction Database)
LPA receptor mediated events, organism-specific biosystem
LPA receptor mediated events
Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
Leukocyte transendothelial migration, conserved biosystem (from KEGG)
Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
Osteopontin-mediated events, organism-specific biosystem (from Pathway Interaction Database)
Osteopontin-mediated events, organism-specific biosystem
Osteopontin-mediated events
PDGFR-beta signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
PDGFR-beta signaling pathway, organism-specific biosystem
PDGFR-beta signaling pathway
Paxillin-dependent events mediated by a4b1, organism-specific biosystem (from Pathway Interaction Database)
Paxillin-dependent events mediated by a4b1, organism-specific biosystem
Paxillin-dependent events mediated by a4b1
Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem (from Pathway Interaction Database)
Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem
Paxillin-independent events mediated by a4b1 and a4b7
Plasma membrane estrogen receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
Plasma membrane estrogen receptor signaling, organism-specific biosystem
Plasma membrane estrogen receptor signaling
Platelet Aggregation (Plug Formation), organism-specific biosystem (from REACTOME)
Platelet Aggregation (Plug Formation), organism-specific biosystemThe tethering of platelets to the site of vascular injury is the first step in the formation of a platelet thrombus. Firm adhesion of these tethered platelets, as well as the additional recruitment o...
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
RAC1 signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
RAC1 signaling pathway, organism-specific biosystem
RAC1 signaling pathway
Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
Regulation of actin cytoskeleton, organism-specific biosystem
Regulation of actin cytoskeleton
Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
Regulation of actin cytoskeleton, conserved biosystem
Regulation of actin cytoskeleton
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by PDGF, organism-specific biosystem (from REACTOME)
Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by PRL, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by PRL, organism-specific biosystem
Signaling events mediated by PRL
Signaling events mediated by PTP1B, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by PTP1B, organism-specific biosystem
Signaling events mediated by PTP1B
Signaling events mediated by focal adhesion kinase, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by focal adhesion kinase, organism-specific biosystem
Signaling events mediated by focal adhesion kinase
Signaling events regulated by Ret tyrosine kinase, organism-specific biosystem (from Pathway Interaction Database)
Signaling events regulated by Ret tyrosine kinase, organism-specific biosystem
Signaling events regulated by Ret tyrosine kinase
p130Cas linkage to MAPK signaling for integrins, organism-specific biosystem (from REACTOME)
p130Cas linkage to MAPK signaling for integrins, organism-specific biosystemIntegrin signaling is linked to the MAP kinase pathway by recruiting p130cas and Crk to the FAK/Src activation complex.

General gene information

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Markers

G54085 (e-PCR)
- UniSTS:109322

BCAR1_714 (e-PCR)
- UniSTS:277024

BCAR1_V85 (e-PCR)
- UniSTS:277024

SHGC-152387 (e-PCR)
- UniSTS:177497

RH123913 (e-PCR)
- UniSTS:136288

D16S3051 (e-PCR)
- UniSTS:8876

Homology

Homologs of the BCAR1 gene: The BCAR1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, and mosquito.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
SH3 domain binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
signal transducer activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
G-protein coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
G-protein coupled receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
T cell receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
actin filament organization	IDA Inferred from Direct Assay more info	PubMed
antigen receptor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
blood coagulation	TAS Traceable Author Statement more info
cell adhesion	IEA Inferred from Electronic Annotation more info
cell chemotaxis	IMP Inferred from Mutant Phenotype more info
cell division	NAS Non-traceable Author Statement more info	PubMed
cell migration	IDA Inferred from Direct Assay more info	PubMed
cell proliferation	TAS Traceable Author Statement more info	PubMed
cellular response to hepatocyte growth factor stimulus	IMP Inferred from Mutant Phenotype more info
epidermal growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
hepatocyte growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info
insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
integrin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
neurotrophin TRK receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
platelet activation	TAS Traceable Author Statement more info
platelet-derived growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
positive regulation of endothelial cell migration	IDA Inferred from Direct Assay more info
regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
regulation of cell growth	TAS Traceable Author Statement more info	PubMed
vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	TAS Traceable Author Statement more info
focal adhesion	IDA Inferred from Direct Assay more info
focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with plasma membrane	IDA Inferred from Direct Assay more info
ruffle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: breast cancer anti-estrogen resistance protein 1

Names: breast cancer anti-estrogen resistance protein 1; Crk-associated substrate p130Cas; Cas scaffolding protein family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170714.1 → NP_001164185.1 breast cancer anti-estrogen resistance protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AB040024, AK293808, AK295809, BU730553

Consensus CDS

CCDS54040.1

UniProtKB/TrEMBL

B4DEV4

UniProtKB/TrEMBL

E9PCL5

UniProtKB/Swiss-Prot

P56945

Related

ENSP00000391669, OTTHUMP00000255558, ENST00000418647, OTTHUMT00000434666

Conserved Domains (3) summary

cd11569
Location:781 – 913
Blast Score: 696

FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module

cl07433
Location:511 – 656
Blast Score: 494

Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

cd12001
Location:51 – 116
Blast Score: 361

SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
NM_001170715.1 → NP_001164186.1 breast cancer anti-estrogen resistance protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.

Source sequence(s)

AB040024, AK124815, BU730553

Consensus CDS

CCDS54043.1

UniProtKB/TrEMBL

B3KWD7

UniProtKB/TrEMBL

E9PCV2

UniProtKB/Swiss-Prot

P56945

Related

ENSP00000377074, OTTHUMP00000174941, ENST00000393422, OTTHUMT00000269016

Conserved Domains (3) summary

cd11569
Location:753 – 885
Blast Score: 694

FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module

cl07433
Location:483 – 628
Blast Score: 493

Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

cd12001
Location:23 – 88
Blast Score: 362

SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
NM_001170716.1 → NP_001164187.1 breast cancer anti-estrogen resistance protein 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (3) is shorter and has a different N-terminus, as compared to isoform 1.

Source sequence(s)

AB040024, AK295809, BU730553, DC317947

Consensus CDS

CCDS54042.1

UniProtKB/Swiss-Prot

P56945

Related

ENSP00000392708, OTTHUMP00000255559, ENST00000420641, OTTHUMT00000434667

Conserved Domains (3) summary

cd11569
Location:753 – 885
Blast Score: 694

FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module

cl07433
Location:483 – 628
Blast Score: 492

Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

cd12001
Location:23 – 88
Blast Score: 362

SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
NM_001170717.1 → NP_001164188.1 breast cancer anti-estrogen resistance protein 1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) has an alternate 5' sequence and an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (4) is shorter, and has a different N-terminus and an additional segment in the middle region, as compared to isoform 1.

Source sequence(s)

AB040024, AY545071, BU730553, DA418642

Consensus CDS

CCDS54038.1

UniProtKB/Swiss-Prot

P56945

Related

ENSP00000377072, OTTHUMP00000255594, ENST00000393420, OTTHUMT00000434756

Conserved Domains (3) summary

cd11569
Location:753 – 885
Blast Score: 695

FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module

cl07433
Location:483 – 628
Blast Score: 492

Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

cd12001
Location:4 – 70
Blast Score: 365

SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
NM_001170718.1 → NP_001164189.1 breast cancer anti-estrogen resistance protein 1 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an exon in the 5' region, resulting in an alternate AUG start codon, as compared to variant 1. The resulting isoform (5) is shorter and has a different N-terminus, as compared to isoform 1.

Source sequence(s)

AB040024, AK027608, AK295809, BU730553

Consensus CDS

CCDS54041.1

UniProtKB/TrEMBL

F5H7Z0

UniProtKB/Swiss-Prot

P56945

Related

ENSP00000443841, OTTHUMP00000255557, ENST00000538440, OTTHUMT00000434665

Conserved Domains (3) summary

cd11569
Location:735 – 867
Blast Score: 693

FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module

cl07433
Location:465 – 610
Blast Score: 492

Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

cd12001
Location:5 – 70
Blast Score: 362

SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
NM_001170719.1 → NP_001164190.1 breast cancer anti-estrogen resistance protein 1 isoform 7

Status: VALIDATED

Description

Transcript Variant: This variant (7) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (7) is shorter and has a different N-terminus, as compared to isoform 1.

Source sequence(s)

AB040024, AK295809, BU730553, DC310094

Consensus CDS

CCDS54037.1

UniProtKB/TrEMBL

F5GXA2

UniProtKB/Swiss-Prot

P56945

Related

ENSP00000440415, OTTHUMP00000255593, ENST00000542031, OTTHUMT00000434755

Conserved Domains (3) summary

cd11569
Location:733 – 865
Blast Score: 693

FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module

cl07433
Location:463 – 608
Blast Score: 492

Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

cd12001
Location:3 – 68
Blast Score: 362

SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
NM_001170720.1 → NP_001164191.1 breast cancer anti-estrogen resistance protein 1 isoform 8

Status: VALIDATED

Description

Transcript Variant: This variant (8) has an alternate internal sequence, as compared to variant 1. The resulting isoform (8) is shorter and has a different N-terminus, as compared to isoform 1.

Source sequence(s)

AB040024, AK302617, BU730553

Consensus CDS

CCDS54039.1

UniProtKB/Swiss-Prot

P56945

Related

ENSP00000440370, OTTHUMP00000255592, ENST00000535626, OTTHUMT00000434754

Conserved Domains (3) summary

cd11569
Location:587 – 719
Blast Score: 692

FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module

cl07433
Location:317 – 462
Blast Score: 486

Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

cl17036
Location:5 – 64
Blast Score: 327

SH3; Src Homology 3 domain superfamily
NM_001170721.1 → NP_001164192.1 breast cancer anti-estrogen resistance protein 1 isoform 9

Status: VALIDATED

Description

Transcript Variant: This variant (9) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (9) is much shorter at the N-terminus, as compared to isoform 1.

Source sequence(s)

AB040024, AC009078, AK124844, BU730553

UniProtKB/TrEMBL

B3KWE2

UniProtKB/Swiss-Prot

P56945

Conserved Domains (2) summary

cd11569
Location:525 – 657
Blast Score: 688

FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module

cl07433
Location:255 – 400
Blast Score: 484

Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
NM_014567.3 → NP_055382.2 breast cancer anti-estrogen resistance protein 1 isoform 6

Status: VALIDATED

Description

Transcript Variant: This variant (6) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (6) is shorter and has a different N-terminus, as compared to isoform 1.

Source sequence(s)

AB040024, AK295809, AK314722, BU730553

Consensus CDS

CCDS10915.1

UniProtKB/TrEMBL

B2RBL9

UniProtKB/Swiss-Prot

P56945

Related

ENSP00000162330, OTTHUMP00000174942, ENST00000162330, OTTHUMT00000269017

Conserved Domains (3) summary

cd11569
Location:735 – 867
Blast Score: 693

FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module

cl07433
Location:465 – 610
Blast Score: 492

Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

cd12001
Location:4 – 70
Blast Score: 366

SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000016.9 Reference GRCh37.p10 Primary Assembly

Range

75262928..75301951, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000148.1 Alternate HuRef

Range

61013718..61052474, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018927.1 Alternate CHM1_1.0

Range

76275436..76314480, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01058126.1 (10709..32630)	None
genomic	ABBA01058127.1	None
genomic	AC009078.6 (138009..138477)	None
genomic	AMYH01007819.1 (5308..27847)	None
genomic	AMYH01007820.1	None
genomic	CH471114.2	EAW95651.1
		EAW95652.1
		EAW95653.1
		EAW95654.1
		EAW95655.1
		EAW95656.1
mRNA	AB040024.1	BAA92711.1
mRNA	AF218451.1	AAF27527.1
mRNA	AJ242987.2	CAB75875.2
mRNA	AK026121.1	None
mRNA	AK027608.1	BAB55230.1
mRNA	AK074958.1	BAC11315.1
mRNA	AK124526.1	BAG54047.1
mRNA	AK124815.1	BAG54099.1
mRNA	AK124844.1	BAG54104.1
mRNA	AK125719.1	BAG54238.1
mRNA	AK127004.1	None
mRNA	AK293808.1	BAG57215.1
mRNA	AK294513.1	BAG57726.1
mRNA	AK295809.1	BAG58627.1
mRNA	AK302617.1	BAH13763.1
mRNA	AK314722.1	BAG37266.1
mRNA	AY545071.1	AAS48631.1
mRNA	BC014402.1	AAH14402.1
mRNA	BC062556.1	AAH62556.1
mRNA	BU730553.1	None
mRNA	DA418642.1	None
mRNA	DC310094.1	None
mRNA	DC317947.1	None
other-genetic	EU831404.1	ACE87091.1
other-genetic	EU831496.1	ACE86415.1