My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    VPS26A vacuolar protein sorting 26 homolog A (S. pombe) [ Homo sapiens ]

    Gene ID: 9559, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    VPS26Aprovided by HGNC
    Official Full Name
    vacuolar protein sorting 26 homolog A (S. pombe)provided by HGNC
    Primary source
    HGNC:12711
    See related
    Ensembl:ENSG00000122958; HPRD:08385; MIM:605506; Vega:OTTHUMG00000018376
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HB58; PEP8A; VPS26; Hbeta58; FLJ12930
    Summary
    This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Help top of page

    Genomic context

    Location :
    10q21.1
    Sequence :
    Chromosome: 10; NC_000010.10 (70883908..70932617)
    See VPS26A in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene actin, gamma 1 pseudogene Neighboring gene serglycin Neighboring gene ribosomal protein S12 pseudogene 17 Neighboring gene suppressor of var1, 3-like 1 (S. cerevisiae) Neighboring gene hexokinase domain containing 1

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling. Berndt JD, et al. J Cell Biol, 2011 Sep 5. PMID 21875946.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (25) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Membrane recruitment of the cargo-selective retromer subcomplex VPS35/29/26 is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.
      Title: Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease.
    3. These observations indicate that the mammalian retromer complex assembles by sequential association of SNX1/2 and Vps26-Vps29-Vps35 subcomplexes on endosomal membranes and that SNX1 and SNX2 play interchangeable but essential roles.
      Title: Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:114930 BioGRID:112171 RYK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114930 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein transporter activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    protein transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    retrograde transport, endosome to Golgi NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    		  
    endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    retromer complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    vesicle IDA
    Inferred from Direct Assay
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    vacuolar protein sorting-associated protein 26A
    Names
    vacuolar protein sorting-associated protein 26A
    vesicle protein sorting 26A
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035260.1 → NP_001030337.1  vacuolar protein sorting-associated protein 26A isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region which results in a frameshift and early translation termination, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AF175266, BC022505, BQ048905, CD358963
      Consensus CDS
      CCDS41536.1
      UniProtKB/TrEMBL
      A8MZ56
      UniProtKB/Swiss-Prot
      O75436
      Related
      ENSP00000378532, ENST00000395098
      Conserved Domains (1) summary
      pfam03643
      Location:8 – 243
      Blast Score: 1013
      Vps26; Vacuolar protein sorting-associated protein 26

    2. NM_004896.3 → NP_004887.2  vacuolar protein sorting-associated protein 26A isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF175266, BC022505, CD358963
      Consensus CDS
      CCDS7286.1
      UniProtKB/Swiss-Prot
      O75436
      Related
      ENSP00000263559, ENST00000263559
      Conserved Domains (1) summary
      pfam03643
      Location:8 – 283
      Blast Score: 1227
      Vps26; Vacuolar protein sorting-associated protein 26

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      70883908..70932617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      64883995..64932609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL442635.11 CAH71779.1
    genomic AL596223.3 CAH71501.1
    genomic CH471083.1 EAW54311.1
      EAW54312.1
      EAW54313.1
    mRNA AF054179.1 AAC39912.1
    mRNA AF175266.1 AAF89954.1
    mRNA AK022992.1 BAB14351.1
    mRNA AK290536.1 BAF83225.1
    mRNA AK297142.1 BAG59643.1
    mRNA AK309021.1 None
    mRNA AK315496.1 BAG37880.1
    mRNA AL110166.1 None
    mRNA BC022505.1 AAH22505.1
    mRNA BQ048905.1 None
    mRNA BX647725.1 None
    mRNA BX649092.1 None
    mRNA CD358963.1 None
    other-genetic EU832481.1 ACE87653.1
    other-genetic EU832561.1 ACE86963.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75436.2 GenPept UniProtKB/Swiss-Prot:O75436
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...