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    CHD1L chromodomain helicase DNA binding protein 1-like [ Homo sapiens ]

    Gene ID: 9557, updated on 6-Feb-2012

    Summary

    Official Symbol
    CHD1Lprovided by HGNC
    Official Full Name
    chromodomain helicase DNA binding protein 1-likeprovided by HGNC
    Primary source
    HGNC:1916
    See related
    Ensembl:ENSG00000131778; HPRD:09880; MIM:613039; Vega:OTTHUMG00000150271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALC1; CHDL
    Summary
    This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants have been described for this gene. [provided by RefSeq, Jan 2012]

    Genomic context

    Location :
    1q12
    Sequence :
    Chromosome: 1; NC_000001.10 (146714291..146767443)
    See CHD1L in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505794 Neighboring gene flavin containing monooxygenase 5 Neighboring gene chaperonin containing TCP1, subunit 8 (theta) pseudogene 1 Neighboring gene ribosomal protein L7a pseudogene 15 Neighboring gene prostaglandin reductase 1 pseudogene Neighboring gene uncharacterized LOC100289211 Neighboring gene olfactory receptor, family 13, subfamily Z, member 1 pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_004275.2     BIND  PubMed CHD1L (ALC1) interacts with ADP-ribose. 
    BioGRID:114929 BioGRID:114109 API5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:128334 APLF    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114929 BioGRID:116151 CBX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:116463 CBX3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:117030 CBX5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:114929 CHD1L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:108289 EIF4A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:109269 H2AFZ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:570000 H3F3AP6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:109271 HIST1H2BB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:124439 HIST1H2BK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:593221 HIST2H2AA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:124981 HIST3H2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:106652 PARP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:115350 PARP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:111577 PRKDC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114929 BioGRID:111914 RFC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:112037 RPA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:112038 RPA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:112039 RPA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:116367 SUPT16H    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:113349 XRCC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114929 BioGRID:113353 XRCC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114929 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ22530

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent DNA helicase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    ATPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ATP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA repair TAS
    Traceable Author Statement
    more info
    PubMed 
    chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    chromodomain-helicase-DNA-binding protein 1-like
    Names
    chromodomain-helicase-DNA-binding protein 1-like
    amplified in liver cancer 1
    amplified in liver cancer protein 1
    NP_004275.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256336.1NP_001243265.1  chromodomain-helicase-DNA-binding protein 1-like isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region which results in translation from a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK026183, AK298424, BC001171, CB153921, DA007597, DA155685
      Conserved Domains (4) summary
      cd03331
      Location:616766
      Blast Score: 623
      Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
      cd00046
      Location:787
      Blast Score: 97
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:261367
      Blast Score: 214
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      PLN03142
      Location:16442
      Blast Score: 1003
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    2. NM_001256337.1NP_001243266.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks several exons in the 5' coding region which results in translation from a downstream start codon, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK026183, AK293157, BC001171, CN255654, DA007597, DA155685
      Conserved Domains (3) summary
      cd03331
      Location:435585
      Blast Score: 621
      Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
      cd00079
      Location:80186
      Blast Score: 213
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      PLN03142
      Location:1261
      Blast Score: 647
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    3. NM_001256338.1NP_001243267.1  chromodomain-helicase-DNA-binding protein 1-like isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks several exons in the 5' coding region which results in translation from a downstream start codon, compared to variant 1. The resulting protein (isoform 5) is shorter when it is compared to isoform 1.
      Source sequence(s)
      BC001171, BC077717, DA007597, DA155685, R46126
      UniProtKB/Swiss-Prot
      Q86WJ1
      Conserved Domains (3) summary
      cd03331
      Location:512662
      Blast Score: 621
      Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
      cd00079
      Location:157263
      Blast Score: 212
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      PLN03142
      Location:44338
      Blast Score: 751
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    4. NM_004284.4NP_004275.4  chromodomain-helicase-DNA-binding protein 1-like isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AF537213, BC001171, DA007597, DA155685, R46126
      Consensus CDS
      CCDS927.1
      UniProtKB/Swiss-Prot
      Q86WJ1
      Related
      ENSP00000358262, OTTHUMP00000016308, ENST00000369258, OTTHUMT00000040377
      Conserved Domains (4) summary
      cd03331
      Location:716866
      Blast Score: 626
      Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
      cd00046
      Location:65187
      Blast Score: 190
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:361467
      Blast Score: 213
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      PLN03142
      Location:46542
      Blast Score: 1180
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    5. NM_024568.2NP_078844.2  chromodomain-helicase-DNA-binding protein 1-like isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site in the 5' coding region which results in translation from a downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK027631, AK223496, BC001171, CN255647, DA007597, DA155685, DA745071, R46126
      Conserved Domains (4) summary
      cd03331
      Location:603753
      Blast Score: 624
      Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
      cd00079
      Location:248354
      Blast Score: 213
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      PLN03142
      Location:2429
      Blast Score: 1003
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cl09099
      Location:174
      Blast Score: 95
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. NR_046070.1 RNA Sequence

      Description
      Transcript Variant: This variant (6) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay.(NMD).
      Source sequence(s)
      BC001171, BC043501, CN255649, DA007597, DA155685, R46126

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      146714291..146767443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      120126695..120180295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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