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CIR1 corepressor interacting with RBPJ, 1 [ Homo sapiens (human) ]

Gene ID: 9541, updated on 12-May-2016
Official Symbol
CIR1provided by HGNC
Official Full Name
corepressor interacting with RBPJ, 1provided by HGNC
Primary source
HGNC:HGNC:24217
See related
Ensembl:ENSG00000138433 HPRD:05568; MIM:605228; Vega:OTTHUMG00000132338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIR
Orthologs
Location:
2q31.1
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (174348150..174395715, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (175212878..175260443, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724194 Neighboring gene long intergenic non-protein coding RNA 1305 Neighboring gene Sp9 transcription factor Neighboring gene secernin 3 Neighboring gene G protein-coupled receptor 155

  • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
  • Notch signaling pathway, organism-specific biosystem (from KEGG)
    Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
  • Notch signaling pathway, conserved biosystem (from KEGG)
    Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with histone deacetylase complex IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
corepressor interacting with RBPJ 1
Names
CBF1 interacting corepressor
CBF1-interacting corepressor
recepin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004882.3NP_004873.3  corepressor interacting with RBPJ 1

    See identical proteins and their annotated locations for NP_004873.3

    Status: VALIDATED

    Source sequence(s)
    BC015040, BC046098, BU596189
    Consensus CDS
    CCDS2256.1
    UniProtKB/Swiss-Prot
    Q86X95
    Related
    ENSP00000339723, OTTHUMP00000163177, ENST00000342016, OTTHUMT00000255460
    Conserved Domains (1) summary
    smart01083
    Location:1349
    Cir_N; N-terminal domain of CBF1 interacting co-repressor CIR

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    174348150..174395715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    175219101..175266631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199075.1: Suppressed sequence

    Description
    NM_199075.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.