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PTGES prostaglandin E synthase [ Homo sapiens (human) ]

Gene ID: 9536, updated on 29-May-2016
Official Symbol
PTGESprovided by HGNC
Official Full Name
prostaglandin E synthaseprovided by HGNC
Primary source
HGNC:HGNC:9599
See related
Ensembl:ENSG00000148344 HPRD:05528; MIM:605172; Vega:OTTHUMG00000020791
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1
Summary
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]
Orthologs
Location:
9q34.3
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (129738336..129777327, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (132500615..132515344, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene N-terminal Xaa-Pro-Lys N-methyltransferase 1 Neighboring gene ankyrin repeat and SOCS box containing 6 Neighboring gene paired related homeobox 2 Neighboring gene PRRX2 antisense RNA 1 Neighboring gene ubiquitin conjugating enzyme E2 V1 pseudogene 4 Neighboring gene torsin family 1 member B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of prostaglandin E synthase (PTGES) in peptide-treated PBMCs PubMed
capsid gag Immunosuppressive peptides corresponding to HIV-1 Capsid amino acids 218-238 upregulate prostaglandin E2 production and induce IL-10 secretion PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC10317

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione binding IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin-E synthase activity EXP
Inferred from Experiment
more info
PubMed 
prostaglandin-E synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 
chronic inflammatory response IEA
Inferred from Electronic Annotation
more info
 
cyclooxygenase pathway TAS
Traceable Author Statement
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin metabolic process TAS
Traceable Author Statement
more info
PubMed 
response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
response to cytokine IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
nuclear envelope lumen IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
prostaglandin E synthase
Names
MGST1-like 1
glutathione S-transferase 1-like 1
microsomal glutathione S-transferase 1-like 1
microsomal prostaglandin E synthase 1
microsomal prostaglandin E synthase-1
p53-induced apoptosis protein 12
p53-induced gene 12 protein
tumor protein p53 inducible protein 12
NP_004869.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004878.4NP_004869.1  prostaglandin E synthase

    See identical proteins and their annotated locations for NP_004869.1

    Status: REVIEWED

    Source sequence(s)
    AL590369, BC008280, BQ927197
    Consensus CDS
    CCDS6927.1
    UniProtKB/Swiss-Prot
    O14684
    Related
    ENSP00000342385, OTTHUMP00000022345, ENST00000340607, OTTHUMT00000054599
    Conserved Domains (1) summary
    pfam01124
    Location:19145
    MAPEG; MAPEG family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    129738336..129777327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519210.1XP_011517512.1  

    See identical proteins and their annotated locations for XP_011517512.1

    UniProtKB/TrEMBL
    A0A024R8D5
    Conserved Domains (1) summary
    pfam01124
    Location:47173
    MAPEG; MAPEG family

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    132649284..132663955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198797.1: Suppressed sequence

    Description
    NM_198797.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.