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POLR1C polymerase (RNA) I polypeptide C, 30kDa [ Homo sapiens (human) ]

Gene ID: 9533, updated on 21-Nov-2014
Official Symbol
POLR1Cprovided by HGNC
Official Full Name
polymerase (RNA) I polypeptide C, 30kDaprovided by HGNC
Primary source
HGNC:HGNC:20194
Locus tag
RP3-337H4.4
See related
Ensembl:ENSG00000171453; HPRD:09661; MIM:610060; Vega:OTTHUMG00000014739
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPA5; TCS3; RPA39; RPA40; RPAC1
Summary
The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Defects in this gene have been associated with Treacher Collins syndrome (TCS). [provided by RefSeq, Mar 2011]
See POLR1C in Epigenomics, MapViewer
Location:
6p21.1
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (43517039..43529376)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43484777..43497114)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 73 Neighboring gene Yip1 domain family, member 3 Neighboring gene exportin 5 Neighboring gene ribosomal protein S2 pseudogene 29 Neighboring gene polymerase (DNA directed), eta Neighboring gene GTP binding protein 2

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-directed RNA polymerase activity TAS
Traceable Author Statement
more info
PubMed 
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
DNA-directed RNA polymerase I complex TAS
Traceable Author Statement
more info
PubMed 
DNA-directed RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA-directed RNA polymerase III complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
DNA-directed RNA polymerases I and III subunit RPAC1
Names
DNA-directed RNA polymerases I and III subunit RPAC1
AC40
RPC40
RNA polymerases I and III subunit AC1
DNA-directed RNA polymerase I subunit C
DNA-directed RNA polymerases I and III 40 kDa polypeptide

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028283.1 

    Range
    5001..9475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_203290.2NP_976035.1  DNA-directed RNA polymerases I and III subunit RPAC1

    See proteins identical to NP_976035.1

    Status: REVIEWED

    Source sequence(s)
    BC008863, BM828768
    Consensus CDS
    CCDS4901.1
    UniProtKB/Swiss-Prot
    O15160
    Related
    ENSP00000361465, OTTHUMP00000016470, ENST00000372389, OTTHUMT00000040652
    Conserved Domains (2) summary
    cd07032
    Location:49339
    RNAP_I_II_AC40; AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
    smart00662
    Location:61336
    RPOLD; RNA polymerases D

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    43202730..43208225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    43517039..43529376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249491.1XP_005249548.1  

    See proteins identical to XP_005249548.1

    UniProtKB/Swiss-Prot
    O15160
    Related
    ENSP00000307212, OTTHUMP00000016468, ENST00000304004, OTTHUMT00000040650
    Conserved Domains (2) summary
    cd07032
    Location:49307
    RNAP_I_II_AC40; AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
    smart00662
    Location:61267
    RPOLD; RNA polymerases D

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    43487909..43492383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004875.2: Suppressed sequence

    Description
    NM_004875.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.