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    NPEPPS aminopeptidase puromycin sensitive [ Homo sapiens (human) ]

    Gene ID: 9520, updated on 5-May-2013
    Official Symbol
    NPEPPSprovided by HGNC
    Official Full Name
    aminopeptidase puromycin sensitiveprovided by HGNC
    Primary source
    HGNC:7900
    See related
    Ensembl:ENSG00000141279; HPRD:07366; MIM:606793; Vega:OTTHUMG00000165471
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSA; AAP-S; MP100
    Summary
    This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]
    Location :
    17q21
    Sequence :
    Chromosome: 17; NC_000017.10 (45608444..45700642)
    See NPEPPS in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 13 Neighboring gene nuclear factor (erythroid-derived 2)-like 3 pseudogene 2 Neighboring gene mitochondrial ribosomal protein L45 pseudogene 2 Neighboring gene karyopherin (importin) beta 1 Neighboring gene TBK1 binding protein 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Cloutier P, et al. PLoS Genet, 2013 Jan. PMID 23349634.
    2. Charting the landscape of tandem BRCT domain-mediated protein interactions. Woods NT, et al. Sci Signal, 2012 Sep 18. PMID 22990118.
    3. A catalogue of putative HIV-1 protease host cell substrates. Impens F, et al. Biol Chem, 2012 Sep. PMID 22944692.
    4. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629.
    5. A high-throughput approach for measuring temporal changes in the interactome. Kristensen AR, et al. Nat Methods, 2012 Sep. PMID 22863883.

    See all (38) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Elevation of NPEPPS activity blocks accumulation of hyperphosphorylated TAU protein and slows down the progression of Alzheimer's disease.
      Title: Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice.
    2. findings show that by promoting autophagic protein clearance, PSA helps protect against accumulation of aggregation-prone proteins and proteotoxicity
      Title: Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy.
    3. attenuated proteolysis of FTDP-17 mutant tau may be explained by increased phosphorylation levels, resulting in resistance to proteolysis.
      Title: Involvement of puromycin-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) mutant tau.
    4. PSA gene was downregulated in PC-3 cells that were treated with CoCl(2). PSA is involved in the proliferation, migration, and invasion of PC-3 cells, which are important determinants of metastasis, via a mechanism that involves MMP-9 modulation.
      Title: Cobalt chloride-induced downregulation of puromycin-sensitive aminopeptidase suppresses the migration and invasion of PC-3 cells.
    5. ApPS Y394F exhibited a 3.3-fold lower affinity for RB-3014, a transition state inhibitor, indicating that Tyr394 is involved in transition state stabilization
      Title: Analysis of conserved residues of the human puromycin-sensitive aminopeptidase.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    pol gag-pol Positional proteomics analysis identifies the cleavage of human aminopeptidase puromycin sensitive (NPEPPS) at amino acid residues 677-678 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:114897 BioGRID:122917 CAMKMT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:107506 CFTR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:107572 CKB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:107612 CLN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:120866 CNDP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:107821 CSE1L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:117481 DAK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:108102 DMWD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:108223 ECT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:109898 EIF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:117646 FBXO25    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:122520 FTO    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:108901 GBAS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:108903 GBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:110137 LDHB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:116184 METAP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:119921 NANS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:120112 OTUD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:111098 PAK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:109180 PDIA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:111221 PFAS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:112096 RPLP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:112109 RPS6KA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:112111 RPS6KA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:112171 RYK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:119599 SCLY    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:119602 SIRT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:114769 SLC9A3R1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:116342 STRAP    BioGRID  PubMed Co-fractionation 
    BioGRID:114897 BioGRID:112910 TGM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:120529 UBA6    BioGRID  PubMed Co-fractionation 
    BioGRID:114897 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:121034 UBFD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114897 BioGRID:124717 ZNF622    BioGRID  PubMed Affinity Capture-MS 
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    antigen processing and presentation of peptide antigen via MHC class I TAS
    Traceable Author Statement
    more info
    		  
    cellular response to hypoxia IDA
    Inferred from Direct Assay
    more info
    		  
    protein polyubiquitination TAS
    Traceable Author Statement
    more info
    		  
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    puromycin-sensitive aminopeptidase
    Names
    puromycin-sensitive aminopeptidase
    metalloproteinase MP100
    cytosol alanyl aminopeptidase
    NP_006301.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006310.3 → NP_006301.3  puromycin-sensitive aminopeptidase

      Status: REVIEWED

      Source sequence(s)
      AJ132583, BC065294, BM723238, DB476543
      Consensus CDS
      CCDS45721.1
      UniProtKB/Swiss-Prot
      P55786
      Related
      ENSP00000320324, OTTHUMP00000229855, ENST00000322157, OTTHUMT00000384269
      Conserved Domains (3) summary
      cd09601
      Location:61 – 504
      Blast Score: 1894
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:53 – 441
      Blast Score: 1449
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:578 – 891
      Blast Score: 512
      DUF3358; Domain of unknown function (DUF3358)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p10 Primary Assembly

      Range
      45608444..45700642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      41029621..41070145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018928.1 Alternate CHM1_1.0

      Range
      46623425..46715719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01041132.1 (50..5713) None
    genomic ABBA01041133.1 None
    genomic ABBA01041134.1 None
    genomic ABBA01041135.1 None
    genomic ABBA01041136.1 None
    genomic ABBA01041137.1 None
    genomic AC025682.6 (33505..125536) None
    genomic AC183084.2 (96884..136463) None
    genomic AF252387.1 AAF70086.1
    genomic AMYH01008449.1 None
    genomic AMYH01008450.1 None
    genomic CH471109.2 EAW94811.1
      EAW94812.1
      EAW94813.1
    mRNA AA864462.1 None
    mRNA AJ132583.1 CAA10709.1
    mRNA AK095877.1 BAG53154.1
    mRNA AK096491.1 None
    mRNA AK096709.1 BAG53355.1
    mRNA AK293450.1 BAH11510.1
    mRNA AK293995.1 BAH11645.1
    mRNA AK296887.1 BAH12449.1
    mRNA AK297107.1 BAH12498.1
    mRNA AK303037.1 BAH13885.1
    mRNA AK311414.1 None
    mRNA BC065294.1 AAH65294.2
    mRNA BM723238.1 None
    mRNA DB476543.3 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55786.2 GenPept UniProtKB/Swiss-Prot:P55786

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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      Supplemental Content

      Table of contents

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        Citations in PubMed identified from shared sequence and PMC links.
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        Link to Protein RefSeqs
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        Link to Nucleotide RefSeq RNAs
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