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GDF15 growth differentiation factor 15 [ Homo sapiens (human) ]

Gene ID: 9518, updated on 26-Aug-2014
Official Symbol
GDF15provided by HGNC
Official Full Name
growth differentiation factor 15provided by HGNC
Primary source
HGNC:30142
See related
Ensembl:ENSG00000130513; HPRD:05608; MIM:605312; Vega:OTTHUMG00000183360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15
Summary
Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009]
See GDF15 in Epigenomics, MapViewer
Location:
19p13.11
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (18386158..18389176)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18496968..18499986)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724342 Neighboring gene LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) Neighboring gene pyroglutamyl-peptidase I Neighboring gene microRNA 3189 Neighboring gene leucine rich repeat containing 25 Neighboring gene single stranded DNA binding protein 4 Neighboring gene inositol-3-phosphate synthase 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
Preferred Names
growth/differentiation factor 15
Names
growth/differentiation factor 15
NRG-1
PTGF-beta
placental TGF-beta
NSAID-activated gene 1 protein
NSAID-regulated gene 1 protein
prostate differentiation factor
macrophage inhibitory cytokine 1
placental bone morphogenetic protein
NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004864.2NP_004855.2  growth/differentiation factor 15 precursor

    See proteins identical to NP_004855.2

    Status: VALIDATED

    Source sequence(s)
    AB000584, BC008962
    Consensus CDS
    CCDS12376.1
    UniProtKB/Swiss-Prot
    Q99988
    Related
    ENSP00000252809, OTTHUMP00000271537, ENST00000252809, OTTHUMT00000466340
    Conserved Domains (1) summary
    smart00204
    Location:211308
    Blast Score: 308
    TGFB; Transforming growth factor-beta (TGF-beta) family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    18386158..18389176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    18062378..18063268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. NW_001841750.1 

    Range
    1688..1996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    18497209..18500231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)