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    HCVgp1 polyprotein [ Hepatitis C virus ]

    Gene ID: 951475, updated on 19-May-2012
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    Summary

    Gene symbol
    HCVgp1
    Gene description
    polyprotein
    Locus tag
    HCVgp1
    Gene type
    protein coding
    RefSeq status
    Reviewed
    Organism
    Hepatitis C virus (serotype: 1a, isolate: H77)
    Lineage
    Viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae; Hepacivirus
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    Genomic context

    Sequence :
    NC_004102.1 (342..9377)

    NC_004102.1Genomic Context describing neighboring genes Neighboring gene protein F

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Detergent-induced activation of the hepatitis C virus genotype 1b RNA polymerase. Weng L, et al. Gene, 2012 Apr 1. PMID 22306265.
    2. HCV NS5A and NS5B enhance expression of human ceramide glucosyltransferase gene. Guo J, et al. Virol Sin, 2012 Feb. PMID 22270805.
    3. Analysis of the PKR-eIF2alpha phosphorylation homology domain (PePHD) of hepatitis C virus genotype 1 in HIV-coinfected patients by ultra-deep pyrosequencing and its relationship to responses to pegylated interferon-ribavirin treatment. Bolcic F, et al. Arch Virol, 2012 Apr. PMID 22270759.
    4. New insights regarding HCV-NS5A structure/function and indication of genotypic differences. Yamasaki LH, et al. Virol J, 2012 Jan 12. PMID 22239820.
    5. Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix α0. Horner SM, et al. J Virol, 2012 Mar. PMID 22238314.

    See all (364) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The hepatitis C virus E2 protein PKR/eIF-2alpha phosphorylation homology domain sequence at the amino acid and nucleotide level was highly conserved among genotype 1 strains.
      Title: Analysis of the PKR-eIF2alpha phosphorylation homology domain (PePHD) of hepatitis C virus genotype 1 in HIV-coinfected patients by ultra-deep pyrosequencing and its relationship to responses to pegylated interferon-ribavirin treatment.
    2. study showed how natural variation in the hepatitis C virus protease nonstructural protein 3/4A sequences might affect susceptibility to first-generation direct-acting antiviral agents
      Title: Peptidomimetic escape mechanisms arise via genetic diversity in the ligand-binding site of the hepatitis C virus NS3/4A serine protease.
    3. characterization of interaction with human estrogen receptor alpha
      Title: Characterization of the interaction between hepatitis C virus NS5B and the human oestrogen receptor alpha.
    4. A motif search indicated conserved glycosylation, phosphorylation and myristoylation sites that could be important in structural stabilization and function of NS5A.
      Title: New insights regarding HCV-NS5A structure/function and indication of genotypic differences.
    5. The authors conclude that hepatitis C virus proteins, especially NS5A and NS5B, have positive effects on the expression of human GlcT-1.
      Title: HCV NS5A and NS5B enhance expression of human ceramide glucosyltransferase gene.
    6. NS4A sequence is highly conserved from Pakistani patients.
      Title: Phylogenetic and structural analysis of HCV nonstructural protein 4A from Pakistani patients.
    7. The hepatitis C virus NS3/4A protein induced Tom70 expression.
      Title: Translocase of outer mitochondrial membrane 70 induces interferon response and is impaired by hepatitis C virus NS3.
    8. Since both degradation of NS4A and activation of HIV-1 LTR were closely correlated and mediated by Vpu, the authors proposed that Vpu impairs the stability of NS4A and releases NS3 from NS3/4A complex for the stimulation of HIV-1 transcription.
      Title: Association of Vpu with hepatitis C virus NS3/4A stimulates transcription of type 1 human immunodeficiency virus.
    9. Helix alpha(0) of NS3 is required for NS3/4A control of RIG-I signaling and HCV replication by directing the membrane targeting of viral and cellular substrates.
      Title: Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix α0.
    10. analysis of detergent-induced activation of the hepatitis C virus genotype 1b RNA polymerase
      Title: Detergent-induced activation of the hepatitis C virus genotype 1b RNA polymerase.
    Submit: New GeneRIF Correction See all (305)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    AAQ86584.1 NP_000030.1 APOA1    BIND  PubMed Hepatitis C virus NS5A interacts with apolipoprotein apoA1. 
    BAC02464.1 NP_004371.1 CREBBP    BIND  PubMed HCV core protein interacts with CBP. 
    BAC02464.1 NP_001420.2 EP300    BIND  PubMed HCV core protein interacts with p300. 
    CAB46677.1 NP_002077.1 GRB2    BIND  PubMed NS5A interacts with Grb2. 
    NP_671491.1 NP_000032.1 APOE    BIND  PubMed ApoE interacts with NS5A. This interaction was modeled on a demonstrated interaction between ApoE from an unspecified species and NS5A from Hepatitis C virus type 1a isolate H77. 
    NP_671491.1 NP_066978.1 CD209    BIND  PubMed HCV strain H77 glycoprotein E2 interacts with DC-SIGN. 
    NP_671491.1 NP_004347.1 CD81    BIND  PubMed E2 interacts with CD81. 
    NP_671491.1 NP_004347.1 CD81    BIND  PubMed CD81 interacts with E2. 
    NP_671491.1 CLEC4M    BIND  PubMed HCV strain H77 glycoprotein E2 interacts with DC-SIGNR. 
    NP_671491.1 NP_671491.1 HCVgp1    BIND  PubMed NS5A interacts with NS5A. This interaction was modeled on a demonstrated interaction between NS5A from an unspecified strain of Hepatitis C virus and NS5A from Hepatitis C virus type 1a isolate H77. 
    NP_671491.1 NP_671491.1 HCVgp1    BIND  PubMed The Hepatitis C virus E1 and E2 glycoproteins interact to form a non-covalently associated heterodimer. 
    NP_671491.1 NP_778225.1 HIST3H2BB    BIND  PubMed NS3 interacts with H2B. This interaction was modeled on a demonstrated interaction between Hepatitis C virus NS3 and H2B from an unspecified species. 
    NP_671491.1 NP_002334.2 LTF    BIND  PubMed LF interacts with E2. 
    NP_671491.1 NP_851341.1 LTF    BIND  PubMed LF interacts with E2. 
    NP_671491.1 NP_005893.1 SMAD3    BIND  PubMed Hepatits C virus NS3 protein interacts with Smad3. 
    NP_671491.1 NP_005893.1 SMAD3    BIND  PubMed Hepatits C virus core protein interacts with Smad3. 
    NP_671491.1 NP_003133.1 SSB    BIND  PubMed NS5A interacts with La. 
    NP_671491.1 NP_001054.1 TF    BIND  PubMed TF interacts with E2. 
    NP_671491.1 NP_004613.1 TSN    BIND  PubMed HCV core interacts with translin. This interaction was modeled on a demonstrated interaction between HCV core from an unspecified strain of Hepatitis C virus and translin from an unspecified species. 
    NP_671491.1 NP_038466.2 UBQLN1    BIND  PubMed NS5B interacts with hPLIC1. This interaction was modeled on a demonstrated interaction between NS5B from an unspecified strain of Hepatitis C virus and human hPLIC1. 
    NP_671491.1 CAA09407.1     BIND  PubMed LF interacts with E2. 
    NP_671491.1 CAB89875.1     BIND  PubMed E2 interacts with CD81. 
    NP_751919.1 NP_001347.2 DDX3X    BIND  PubMed Core interacts with DDX3. 
    NP_751919.1 NP_751919.1 HCVgp1    BIND  PubMed HCV core interacts with itself. 
    NP_751919.1 NP_751919.1 HCVgp1    BIND  PubMed Core interacts with Core. 
    NP_751919.1 NP_751927.1 HCVgp1    BIND  PubMed HCV core interacts with NS5A. 
    NP_751919.1 NC_004102.1 HCVgp2    BIND  PubMed HCV 5'-noncoding region (NCR) interacts with HCV core protein. 
    NP_751919.1 NP_112552.1 HNRNPK    BIND  PubMed Hepatitis C virus core protein interacts with hnRNP K. 
    NP_751919.1 NP_002333.1 LTBR    BIND  PubMed HCV core interacts with lymphotoxin-beta receptor. 
    NP_751919.1 NP_000537.2 TP53    BIND  PubMed HCV core protein interacts with p53 
    NP_751919.1 NP_000537.2 TP53    BIND  PubMed Hepatitis C virus core protein interacts with human p53. 
    NP_751919.1 BAB87244.1 TP73    BIND  PubMed HCV core protein interacts with p73 
    NP_751919.1 BAB87245.1 TP73    BIND  PubMed HCV core protein interacts with p73 
    NP_751919.1 CAA72219.1 TP73    BIND  PubMed HCV core protein interacts with p73. 
    NP_751919.1 NP_005418.1 TP73    BIND  PubMed HCV core protein interacts with p73. 
    NP_751919.1 NP_003395.1 YWHAB    BIND  PubMed HCV core interacts with 14-3-3 beta. This interaction was modeled on a demonstrated interaction between HCV core protein and rat 14-3-3 beta. 
    NP_751919.1 NP_006752.1 YWHAE    BIND  PubMed HCV core interacts with 14-3-3E. 
    NP_751919.1 NP_003397.1 YWHAZ    BIND  PubMed HCV core interacts with 14-3-3 zeta. This interaction was modeled on a demonstrated interaction between HCV core protein and yeast Bmh1(14-3-3). 
    NP_751920.1 NP_751919.1 HCVgp1    BIND  PubMed E1 interacts with Core. This interaction was modeled on a demonstrated interaction between E1 and Core both from an unspecified HCV strain. 
    NP_751920.1 NP_751919.1 HCVgp1    BIND  PubMed E1 interacts with Capsid. This interaction was modeled on a demonstrated interaction between E1 and Capsid both from an unspecified HCV strain. 
    NP_751920.1 NP_751921.1 HCVgp1    BIND  PubMed E1 interacts with E2 to form a heterodimer. This interaction was modeled on a demonstrated interaction between E1 and E2 from an unspecified strain of Hepatitis C virus type 1a. 
    NP_751921.1 NP_004347.1 CD81    BIND  PubMed E2 interacts with CD81. 
    NP_751921.1 NP_004347.1 CD81    BIND  PubMed CD81 interacts with E2. 
    NP_751923.1 NP_751923.1 HCVgp1    BIND  PubMed NS2 interacts with NS2. 
    NP_751923.1 NP_751926.1 HCVgp1    BIND  PubMed NS2 interacts with NS4B. 
    NP_751923.1 NP_803144.1 HCVgp1    BIND  PubMed NS2 interacts with NS3. 
    NP_751925.1 NP_751925.1 HCVgp1    BIND  PubMed NS4A interacts with NS4A. 
    NP_751925.1 NP_751926.1 HCVgp1    BIND  PubMed NS4A interacts with NS4B. 
    NP_751925.1 NP_751926.1 HCVgp1    BIND  PubMed NS4A interacts with NS4B. 
    NP_751925.1 NP_751927.1 HCVgp1    BIND  PubMed NS4A interacts with NS5A. 
    NP_751925.1 NP_751927.1 HCVgp1    BIND  PubMed NS4A interacts with NS5A. 
    NP_751925.1 NP_751928.1 HCVgp1    BIND  PubMed NS4A interacts with NS5B. 
    NP_751926.1 NP_004372.3 ATF6B    BIND  PubMed Hepatitis C virus (HCV) NS4B interacts with human CREB-RP. 
    NP_751926.1 NP_751926.1 HCVgp1    BIND  PubMed NS4B interacts with NS4B. 
    NP_751926.1 NP_751927.1 HCVgp1    BIND  PubMed NS4B interacts with NS5A. 
    NP_751926.1 NP_751927.1 HCVgp1    BIND  PubMed NS4B interacts with NS5A. 
    NP_751926.1 NP_751928.1 HCVgp1    BIND  PubMed NS4B interacts with NS5B. 
    NP_751927.1 NP_000030.1 APOA1    BIND  PubMed Hepatitis C virus NS5A interacts with apolipoprotein apoA1. 
    NP_751927.1 NP_036289.2 FBXL2    BIND  PubMed NS5A interacts with FBL2. 
    NP_751927.1 NP_002028.1 FYN    BIND  PubMed NS5A interacts with Fyn. 
    NP_751927.1 NP_002101.2 HCK    BIND  PubMed NS5A interacts with Hck. 
    NP_751927.1 NP_751927.1 HCVgp1    BIND  PubMed NS5A interacts with NS5A. 
    NP_751927.1 NP_751928.1 HCVgp1    BIND  PubMed NS5A interacts with NS5B. 
    NP_751927.1 NP_751928.1 HCVgp1    BIND  PubMed NS5A interacts with NS5B. 
    NP_751927.1 NP_002262.3 IPO5    BIND  PubMed Hepatitis C virus (HCV) nonstructural protein 5A interacts with karyopherin beta 3. 
    NP_751927.1 NP_002218.1 JAK1    BIND  PubMed NS5A interacts with Jak1. This interaction was modeled on a demonstrated interaction between NS5A from Hepatitis C virus and Jak1 from an unspecified species. 
    NP_751927.1 NP_005347.2 LCK    BIND  PubMed NS5A interacts with Lck. 
    NP_751927.1 NP_002341.1 LYN    BIND  PubMed NS5A interacts with Lyn. 
    NP_751927.1 NP_006653.1 SRCAP    BIND  PubMed NS5A interacts with SRCAP. 
    NP_751927.1 NP_003178.1 TAF9    BIND  PubMed hTAFII32 interacts with the Hepatitis C virus protein NS5A. 
    NP_751927.1 NP_000537.2 TP53    BIND  PubMed NS5A interacts with p53. 
    NP_751927.1 NP_000537.2 TP53    BIND  PubMed p53 interacts with the Hepatitis C virus protein NS5A. 
    NP_751927.1 NP_066961.2 TRAF2    BIND  PubMed NS5A interacts with TRAF2. This interaction was modeled on a demonstrated interaction between NS5A HCV Korean isolate and TRAF2 from an unspecified species. 
    NP_751927.1 NP_919415.1 VAPA    BIND  PubMed NS5A interacts with hVAP-33. 
    NP_751927.1 NP_919415.1 VAPA    BIND  PubMed hVAP-33 interacts with NS5A. 
    NP_751927.1 P06814     BIND  PubMed NS5A interacts with m-Calpain. 
    NP_751928.1 NP_001093.1 ACTN1    BIND  PubMed NS5B interacts with alpha-actinin. 
    NP_751928.1 NP_001958.1 EIF4A2    BIND  PubMed heIF4AII interacts with NS5B. 
    NP_751928.1 NP_060015.1 HAO1    BIND  PubMed NS5B interacts with hydroxyacid oxidase 1. 
    NP_751928.1 AB191333.1 HCVgp1    BIND  PubMed NS5B interacts with HCV RNA. 
    NP_751928.1 NP_751928.1 HCVgp1    BIND  PubMed NS5B interacts with NS5B. 
    NP_751928.1 NP_005372.1 NCL    BIND  PubMed Nucleolin interacts with NS5B. 
    NP_751928.1 NP_000933.1 PPIB    BIND  PubMed CyPB interacts with NS5B. 
    NP_751928.1 NP_004614.2 TTC4    BIND  PubMed NS5B interacts with tetratricopeptide repeat protein 4. 
    NP_751928.1 NP_919415.1 VAPA    BIND  PubMed NS5B interacts with hVAP-33. 
    NP_751928.1 NP_919415.1 VAPA    BIND  PubMed hVAP-33 interacts with NS5B. 
    NP_803144.1 NP_751925.1 HCVgp1    BIND  PubMed NS3 interacts with NS4A. 
    NP_803144.1 NP_751925.1 HCVgp1    BIND  PubMed NS3 interacts with NS4A. 
    NP_803144.1 NP_751928.1 HCVgp1    BIND  PubMed NS3 interacts with NS5B. 
    NP_803144.1 NP_803144.1 HCVgp1    BIND  PubMed NS3 interacts with NS3. 
    NP_803144.1 NP_006100.2 PRMT5    BIND  PubMed SKB1 interacts with NS3. 
    NP_803144.1 NP_000537.2 TP53    BIND  PubMed NS3 interacts with p53. 
    NP_803144.1     BIND  PubMed NS3 hydrolyzes dGTP. 
    NP_803144.1     BIND  PubMed NS3 hydrolyzes dCTP. 
    NP_803144.1     BIND  PubMed NS3 hydrolyzes dTTP. 
    NP_803144.1     BIND  PubMed NS3 hydrolyzes dATP. 
    NP_803144.1     BIND  PubMed NS3 hydrolyzes UTP. 
    NP_803144.1     BIND  PubMed NS3 hydrolyzes CTP. 
    NP_803144.1     BIND  PubMed NS3 hydrolyzes GTP. 
    NP_803144.1     BIND  PubMed NS3 hydrolyzes ATP. 
    P26663 P26663     BIND  PubMed NS3 cleaves NS5A-NS5B polyprotein. 
    P27958 P27958 HCVgp1    BIND  PubMed NS2 interacts with NS4A. 
    P27958 P27958 HCVgp1    BIND  PubMed NS5A interacts with E1. 
    P27958 P27958 HCVgp1    BIND  PubMed NS3 interacts with E2. 
    P27958 P27958 HCVgp1    BIND  PubMed HCV Core protein interacts with a second core protein molecule. 
    P27958 P27958 HCVgp1    BIND  PubMed NS3 interacts with NS4A. 
    BioGRID:1205534 BioGRID:114196 AKR1C3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:1205534 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:1205534 BioGRID:113945 HIST2H2BE    BioGRID  PubMed Reconstituted Complex 
    BioGRID:1205534 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:1205534 BioGRID:115492 PSME3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:1205534 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:1205534 BioGRID:113185 UBE3A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:1205534 BioGRID:119007 UBQLN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:1205534 BioGRID:113360 YY1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
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    General protein information

    Names
    polyprotein
    core protein
    E1 protein
    E2 protein
    p7 protein
    NS2 protein
    NS3 protease/helicase
    NS4A protein
    NS4B protein
    NS5A protein
    NS5B RNA-dependent RNA polymerase
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    mRNA and Protein(s)

    1. NP_671491.1 polyprotein [Hepatitis C virus]

      Conserved Domains (15) summary
      cd00046
      Location:1224 – 1351
      Blast Score: 128
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:1378 – 1455
      Blast Score: 121
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd01699
      Location:2536 – 2818
      Blast Score: 371
      RNA_dep_RNAP; RNA_dep_RNAP: RNA-dependent RNA polymerase (RdRp) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage. RdRp catalyzes synthesis of the RNA strand complementary to a given RNA template. RdRps of many viruses are ...
      pfam01001
      Location:1728 – 1921
      Blast Score: 635
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b
      pfam01539
      Location:193 – 382
      Blast Score: 1008
      HCV_env; Hepatitis C virus envelope glycoprotein E1
      pfam01542
      Location:116 – 190
      Blast Score: 247
      HCV_core; Hepatitis C virus core protein
      pfam01560
      Location:386 – 729
      Blast Score: 1934
      HCV_NS1; Hepatitis C virus non-structural protein E2/NS1
      pfam02907
      Location:1056 – 1204
      Blast Score: 588
      Peptidase_S29; Hepatitis C virus NS3 protease
      pfam01506
      Location:1974 – 1996
      Blast Score: 121
      HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
      pfam01543
      Location:2 – 115
      Blast Score: 462
      HCV_capsid; Hepatitis C virus capsid protein
      pfam08300
      Location:2006 – 2067
      Blast Score: 324
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain
      pfam08301
      Location:2068 – 2168
      Blast Score: 411
      HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
      pfam12941
      Location:2179 – 2420
      Blast Score: 843
      HCV_NS5a_C; HCV NS5a protein C-terminal region
      pfam01006
      Location:1658 – 1711
      Blast Score: 160
      HCV_NS4a; Hepatitis C virus non-structural protein NS4a
      pfam01538
      Location:811 – 1005
      Blast Score: 863
      HCV_NS2; Hepatitis C virus non-structural protein NS2
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF009606.1 AAB66324.1
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    Additional Links

    Gene LinkOut

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