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    FXR2 fragile X mental retardation, autosomal homolog 2 [ Homo sapiens ]

    Gene ID: 9513, updated on 11-May-2012

    Summary

    Official Symbol
    FXR2provided by HGNC
    Official Full Name
    fragile X mental retardation, autosomal homolog 2provided by HGNC
    Primary source
    HGNC:4024
    See related
    Ensembl:ENSG00000129245; HPRD:05629; MIM:605339
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FXR2P; FMR1L2
    Summary
    The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    17p13.1
    Sequence :
    Chromosome: 17; NC_000017.10 (7494548..7518215, complement)
    See FXR2 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene CD68 molecule Neighboring gene mannose-P-dolichol utilization defect 1 Neighboring gene SRY (sex determining region Y)-box 15 Neighboring gene sex hormone-binding globulin Neighboring gene spermidine/spermine N1-acetyltransferase family member 2 Neighboring gene ATPase, Na+/K+ transporting, beta 2 polypeptide

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P51116 Q9Y2J4 AMOTL2    HPRD  PubMed  
    P51116 Q9BXS5 AP1M1    HPRD  PubMed  
    P51116 Q96CW1 AP2M1    HPRD  PubMed  
    P51116 Q15041 ARL6IP1    HPRD  PubMed  
    P51116 Q5T681 C10orf62    HPRD  PubMed  
    P51116 NDP52 CALCOCO2    HPRD  PubMed  
    P51116 P35520 CBS    HPRD  PubMed  
    P51116 Coiled-coil domain containing 33 CCDC33    HPRD  PubMed  
    P51116 Q15834 CCDC85B    HPRD  PubMed  
    P51116 P38432 COIL    HPRD  PubMed  
    P51116 Q96F07 CYFIP2    HPRD  PubMed  
    P51116 Q7Z7J5 DPPA2    HPRD  PubMed  
    P51116 P09467 FBP1    HPRD  PubMed  
    P51116 Q06787 FMR1    HPRD  PubMed  
    P51116 P02794 FTH1    HPRD  PubMed  
    P51116 P51114 FXR1    HPRD  PubMed  
    P51116 P51116 FXR2    HPRD  PubMed  
    P51116 G kinase anchoring protein 1 GKAP1    HPRD  PubMed  
    P51116 Q8N5I3 KCNRG    HPRD  PubMed  
    P51116 Q8WVF5 KCTD4    HPRD  PubMed  
    P51116 Q5T5P2 KIAA1217    HPRD  PubMed  
    P51116 P35900 KRT20    HPRD  PubMed  
    P51116 Chromosome 19 open reading frame 50 KXD1    HPRD  PubMed  
    P51116 Q9UIC8 LCMT1    HPRD  PubMed  
    P51116 O95751 LDOC1    HPRD  PubMed  
    P51116 Q9NS73 MBIP    HPRD  PubMed  
    P51116 Q96EZ8 MCRS1    HPRD  PubMed  
    P51116 Q9HAF1 MEAF6    HPRD  PubMed  
    P51116 O43639 NCK2    HPRD  PubMed  
    P51116 EF hand calcium binding protein 2 NECAB2    HPRD  PubMed  
    P51116 Q15233 NONO    HPRD  PubMed  
    P51116 P49902 NT5C2    HPRD  PubMed  
    P51116 P22234 PAICS    HPRD  PubMed  
    P51116 P61457 PCBD1    HPRD  PubMed  
    P51116 P61289 PSME3    HPRD  PubMed  
    P51116 Q9UI14 RABAC1    HPRD  PubMed  
    P51116 RALY RNA binding protein-like RALYL    HPRD  PubMed  
    P51116 Q99708 RBBP8    HPRD  PubMed  
    P51116 P38159 RBMX    HPRD  PubMed  
    P51116 Q93062 RBPMS    HPRD  PubMed  
    P51116 P49247 RPIA    HPRD  PubMed  
    P51116 O95197 RTN3    HPRD  PubMed  
    P51116 Q9NQC3 RTN4    HPRD  PubMed  
    P51116 O00161 SNAP23    HPRD  PubMed  
    P51116 O60232 SSSCA1    HPRD  PubMed  
    P51116 Q9NVV9 THAP1    HPRD  PubMed  
    P51116 P13805 TNNT1    HPRD  PubMed  
    P51116 Q12933 TRAF2    HPRD  PubMed  
    P51116 Q14134 TRIM29    HPRD  PubMed  
    P51116 O94972 TRIM37    HPRD  PubMed  
    P51116 Q9Y3Q8 TSC22D4    HPRD  PubMed  
    P51116 Q8NAP8 ZBTB8B    HPRD  PubMed  
    P51116 Q9Y4E5 ZNF451    HPRD  PubMed  
    BioGRID:114890 BioGRID:119530 AMOTL2    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:114421 AP1M1    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:107587 AP2M1    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:116812 ARL6IP1    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:135946 C10orf62    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:115535 CALCOCO2    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:107321 CBS    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:123126 CCDC33    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:116198 CCDC85B    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:116800 CYFIP1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:114890 BioGRID:127407 DPPA2    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:108431 EWSR1    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:108497 FBP1    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:108619 FMR1    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid 
    BioGRID:114890 BioGRID:108773 FTH1    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:113760 FXR1    BioGRID  PubMed Co-purification; Reconstituted Complex; Two-hybrid 
    BioGRID:114890 BioGRID:114890 FXR2    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:123231 GKAP1    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:109424 HNRNPC    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:129592 KCNRG    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:132114 KCTD4    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:121111 KIAA1217    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:119979 KRT20    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:122501 KXD1    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:119549 LCMT1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:114890 BioGRID:117169 LDOC1    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:119612 MBIP    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:115710 MCRS1    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:122280 MEAF6    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:114833 MED7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114890 BioGRID:114020 NCK2    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:120035 NECAB2    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:110904 NONO    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:116627 NT5C2    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:120112 OTUD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114890 BioGRID:115852 PAICS    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:111125 PCBD1    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:111549 PRKAA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114890 BioGRID:115492 PSME3    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:115818 RABAC1    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:126498 RALYL    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:111867 RBBP8    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:118134 RBMX    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:116220 RBPMS    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:116594 RPIA    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:115598 RTN3    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:121400 RTN4    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:114303 SNAP23    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:115788 SSSCA1    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:118878 TBK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114890 BioGRID:115103 TBKBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114890 BioGRID:112873 TERF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114890 BioGRID:120448 THAP1    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:112992 TNNT1    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:113038 TRAF2    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:117177 TRIM29    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:110678 TRIM37    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:123563 TSC22D4    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114890 BioGRID:575543 ZBTB8A    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:117502 ZNF451    BioGRID  PubMed Two-hybrid 
    BioGRID:114890 BioGRID:129825 ZSCAN1    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosolic large ribosomal subunit TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    fragile X mental retardation syndrome-related protein 2
    Names
    fragile X mental retardation syndrome-related protein 2
    fragile X-mental retardation 1-like 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028105.1 RefSeqGene

      Range
      5001..28668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004860.3NP_004851.2  fragile X mental retardation syndrome-related protein 2

      Status: REVIEWED

      Source sequence(s)
      AA593676, BC020090, DA114906
      Consensus CDS
      CCDS45604.1
      UniProtKB/Swiss-Prot
      P51116
      Related
      ENSP00000250113, ENST00000250113
      Conserved Domains (4) summary
      cd00105
      Location:296362
      Blast Score: 127
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam12235
      Location:502525
      Blast Score: 83
      FXR1P_C; Fragile X-related 1 protein C terminal
      cl00098
      Location:230290
      Blast Score: 97
      KH-II; KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional ...
      cl15261
      Location:69127
      Blast Score: 127
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      7494548..7518215, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      7388710..7412259, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC007421.13 (57419..77798) None
    genomic AC016876.10 None
    genomic AF044263.1 AAC03357.1
    genomic CH471108.2 EAW90154.1
      EAW90155.1
    genomic FJ695203.1 None
    mRNA AA593676.1 None
    mRNA AK226082.1 None
    mRNA AK313836.1 BAG36569.1
    mRNA BC020090.1 AAH20090.1
    mRNA BC051907.1 AAH51907.1
    mRNA BC067272.1 AAH67272.1
    mRNA BT009817.1 AAP88819.1
    mRNA DA114906.1 None
    mRNA U31501.1 AAC50292.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51116.2 GenPept UniProtKB/Swiss-Prot:P51116

      Supplemental Content

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