ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 [Homo sapiens] - Gene

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Summary

Official Symbol: ADAMTS1provided by HGNC
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 1provided by HGNC
Primary source: HGNC:217
See related: Ensembl:ENSG00000154734; HPRD:05530; MIM:605174; Vega:OTTHUMG00000078688
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C3-C5; METH1
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 21q21.2

Sequence :: Chromosome: 21; NC_000021.8 (28208606..28217728, complement)

See ADAMTS1 in Epigenomics, MapViewer

Chromosome 21 - NC_000021.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ADAMTS-1 was present in human coronary atherosclerotic plaques; ADAMDTS-1 was differentially expressed between acute myocardial infarction and stable angina; and ADAMTS-1 immunopositive cells were mainly macrophages.
Title: Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina.
AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo.
Title: AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo.
The correlation between its expression in cumulus granulosa cells and oocyte fertilization capacity suggests a role for ADAMTS-1 in human cumulus function
Title: ADAMTS-1: a new human ovulatory gene and a cumulus marker for fertilization capacity.
ADAMTS1 expression is elevated in endometrial adenocarcinoma
Title: PGF2α-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variants of ADAMTS1 modify the effectiveness of statins in reducing the risk of myocardial infarction.
ADAMTS1 is an important regulatory factor of angiogenesis and tumor growth in prostate tumors, where modified ADAMTS1 expression resulted in markedly changed blood vessel morphology, possibly related to altered thrombospondin 1 levels.
Title: ADAMTS1 alters blood vessel morphology and TSP1 levels in LNCaP and LNCaP-19 prostate tumors.
Study documents the expression of ADAMTS1 in aggressive and highly plastic melanoma and Ewing sarcoma cells. Inhibiting ADAMTS1 compromised the endothelial mimetic attributes observed.
Title: ADAMTS1 contributes to the acquisition of an endothelial-like phenotype in plastic tumor cells.
results indicate that the antiangiogenic activity of TSP1 is differentially regulated by ADAMTS1 in the liver and lung, emphasizing the concept that regulation of angiogenesis is varied in different tissue environments.
Title: Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1.
cleavage of semaphorin 3C induced by ADAMTS1 promotes the migration of breast cancer cells, indicating that the co-expression of these molecules in tumors may contribute to the metastatic program
Title: The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration.
ADAMTS1 proteolytic action mimics the outcome of genetic deletion of this proteoglycan with regards to focal adhesion. Findings suggest that the shedding of syndecan-4 by ADAMTS1 disrupts cell adhesion and promotes cell migration.
Title: Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion.

Submit: New GeneRIF Correction See all (40)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
AAD48080.1	NP_003367.3	VEGFA	BIND	PubMed	ADAMTS1 interacts with VEGF165
Q9UHI8	P01023	A2M	HPRD	PubMed
Q9UHI8	P16112	ACAN	HPRD	PubMed
Q9UHI8	P09958	FURIN	HPRD	PubMed
Q9UHI8	P13611	VCAN	HPRD	PubMed
Q9UHI8	P15692	VEGFA	HPRD	PubMed
BioGRID:114888	BioGRID:106524	A2M	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114888	BioGRID:133990	USP17	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114888	BioGRID:113265	VEGFA	BioGRID	PubMed	Affinity Capture-Western; Co-purification; Reconstituted Complex

Function	Evidence Code	Pubs
heparin binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
metallopeptidase activity	TAS Traceable Author Statement more info	PubMed
peptidase activity	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
heart trabecula formation	IEA Inferred from Electronic Annotation more info
integrin-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
kidney development	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	TAS Traceable Author Statement more info	PubMed
ovulation from ovarian follicle	IEA Inferred from Electronic Annotation more info
proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
basement membrane	IEA Inferred from Electronic Annotation more info
cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 1

Names: A disintegrin and metalloproteinase with thrombospondin motifs 1; METH-1; ADAM-TS1; ADAMTS-1; ADAM-TS 1; human metalloproteinase with thrombospondin type 1 motifs; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006988.3 → NP_008919.3 A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein

Status: REVIEWED

Source sequence(s)

AF207664, AW163724, BC036515

Consensus CDS

CCDS33524.1

UniProtKB/TrEMBL

Q8NE26

UniProtKB/Swiss-Prot

Q9UHI8

Related

ENSP00000284984, OTTHUMP00000096354, ENST00000284984, OTTHUMT00000171650

Conserved Domains (5) summary

cd04273
Location:258 – 463
Blast Score: 736

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

cl15278
Location:562 – 614
Blast Score: 167

TSP_1; Thrombospondin type 1 domain

pfam01562
Location:72 – 167
Blast Score: 267

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:725 – 829
Blast Score: 340

ADAM_spacer1; ADAM-TS Spacer 1

cl15456
Location:468 – 548
Blast Score: 174

ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000021.8 Reference GRCh37.p5 Primary Assembly

Range

28208606..28217728, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000153.1 Alternate HuRef

Range

13613149..13622273, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP001598.1	None
genomic	AP001599.1 (38757..47879)	None
genomic	AP001697.1	BAA95502.1
genomic	CH471079.2	EAX09951.1
		EAX09952.1
mRNA	AB037767.1	BAA92584.1
mRNA	AF060152.1	AAD48080.1
mRNA	AF170084.1	AAF15317.1
mRNA	AF207664.1	AAF23772.1
mRNA	AK023795.1	None
mRNA	AK129873.1	BAC85245.1
mRNA	AK314475.1	BAG37080.1
mRNA	AL162080.1	CAB82413.1
mRNA	AW163724.1	None
mRNA	BC036515.2	AAH36515.1
mRNA	BX647388.1	CAI46043.1
mRNA	DQ108407.1	AAZ73034.1
other-genetic	DQ896765.2	ABM87764.1
other-genetic	EU176454.1	ABW03905.1

Protein Accession	Links
Protein Accession	GenePept Link	UniProtKB Link
Q5HYL0	GenPept	UniProtKB/TrEMBL:Q5HYL0
Q6ZP79	GenPept	UniProtKB/TrEMBL:Q6ZP79
Q8NE26	GenPept	UniProtKB/TrEMBL:Q8NE26
Q9UHI8.4	GenPept	UniProtKB/Swiss-Prot:Q9UHI8