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KIF23 kinesin family member 23 [ Homo sapiens (human) ]

Gene ID: 9493, updated on 12-May-2016
Official Symbol
KIF23provided by HGNC
Official Full Name
kinesin family member 23provided by HGNC
Primary source
HGNC:HGNC:6392
See related
Ensembl:ENSG00000137807 HPRD:05455; MIM:605064; Vega:OTTHUMG00000172062
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHO1; KNSL5; MKLP1; MKLP-1
Summary
The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Orthologs
Location:
15q23
Exon count:
26
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (69414246..69448427)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69706585..69740766)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723548 Neighboring gene uncharacterized LOC105370875 Neighboring gene progestin and adipoQ receptor family member 5 Neighboring gene RNA, 5S ribosomal pseudogene 398 Neighboring gene uncharacterized LOC145694 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 pseudogene Neighboring gene uncharacterized LOC105370876 Neighboring gene ribosomal protein lateral stalk subunit P1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora B signaling, organism-specific biosystem
    Aurora B signaling
  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Kinesins, organism-specific biosystem (from REACTOME)
    Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
    MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Mitotic Telophase/Cytokinesis, organism-specific biosystem (from REACTOME)
    Mitotic Telophase/Cytokinesis, organism-specific biosystemIn this final phase of mitosis, new membranes are formed around two sets of chromatids and two daughter cells are formed. The chromosomes and the spindle fibers disperse, and the fiber ring around th...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actomyosin contractile ring assembly IEA
Inferred from Electronic Annotation
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
microtubule-based movement TAS
Traceable Author Statement
more info
 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle elongation TAS
Traceable Author Statement
more info
PubMed 
mitotic spindle midzone assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
plus-end-directed vesicle transport along microtubule IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
centralspindlin complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
intercellular bridge IEA
Inferred from Electronic Annotation
more info
 
kinesin complex TAS
Traceable Author Statement
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
kinesin-like protein KIF23
Names
kinesin-like 5 (mitotic kinesin-like protein 1)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042269.1 RefSeqGene

    Range
    5001..39182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001281301.1NP_001268230.1  kinesin-like protein KIF23 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, initiates translation at an alternate start codon, and has multiple differences in the coding region compared to variant 1. The resulting protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA291944, AC027237, AK308322, BG939827, DB445953
    Conserved Domains (3) summary
    pfam00225
    Location:101321
    Kinesin; Kinesin motor domain
    pfam05852
    Location:403525
    DUF848; Gammaherpesvirus protein of unknown function (DUF848)
    cl22853
    Location:106324
    Motor_domain; Myosin and Kinesin motor domain.
  2. NM_004856.6NP_004847.2  kinesin-like protein KIF23 isoform 2

    See identical proteins and their annotated locations for NP_004847.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AA291944, AC027237, BC051826, BI093060, DB445953
    Consensus CDS
    CCDS32279.1
    UniProtKB/Swiss-Prot
    Q02241
    Related
    ENSP00000453386, OTTHUMP00000247578, ENST00000559279, OTTHUMT00000416676
    Conserved Domains (3) summary
    smart00129
    Location:25442
    KISc; Kinesin motor, catalytic domain. ATPase
    pfam05852
    Location:513635
    DUF848; Gammaherpesvirus protein of unknown function (DUF848)
    cd01368
    Location:24434
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
  3. NM_138555.3NP_612565.1  kinesin-like protein KIF23 isoform 1

    See identical proteins and their annotated locations for NP_612565.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA291944, AC027237, BC017705, DB445953, DR000298
    Consensus CDS
    CCDS32278.1
    UniProtKB/Swiss-Prot
    Q02241
    Related
    ENSP00000260363, ENST00000260363
    Conserved Domains (3) summary
    smart00129
    Location:25442
    KISc; Kinesin motor, catalytic domain. ATPase
    pfam05852
    Location:513635
    DUF848; Gammaherpesvirus protein of unknown function (DUF848)
    cd01368
    Location:24434
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

    Range
    69414246..69448427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254796.2XP_005254853.1  

    Conserved Domains (3) summary
    smart00129
    Location:25456
    KISc; Kinesin motor, catalytic domain. ATPase
    pfam05852
    Location:527649
    DUF848; Gammaherpesvirus protein of unknown function (DUF848)
    cd01368
    Location:24448
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
  2. XM_005254797.2XP_005254854.1  

    Conserved Domains (3) summary
    smart00129
    Location:25456
    KISc; Kinesin motor, catalytic domain. ATPase
    pfam05852
    Location:527649
    DUF848; Gammaherpesvirus protein of unknown function (DUF848)
    cd01368
    Location:24448
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
  3. XM_005254798.2XP_005254855.1  

    Conserved Domains (3) summary
    smart00129
    Location:25456
    KISc; Kinesin motor, catalytic domain. ATPase
    pfam05852
    Location:527649
    DUF848; Gammaherpesvirus protein of unknown function (DUF848)
    cd01368
    Location:24448
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
  4. XM_005254799.2XP_005254856.1  

    Conserved Domains (3) summary
    smart00129
    Location:25456
    KISc; Kinesin motor, catalytic domain. ATPase
    pfam05852
    Location:527649
    DUF848; Gammaherpesvirus protein of unknown function (DUF848)
    cd01368
    Location:24448
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
  5. XM_011522238.1XP_011520540.1  

    Conserved Domains (2) summary
    pfam05852
    Location:417539
    DUF848; Gammaherpesvirus protein of unknown function (DUF848)
    cl22853
    Location:106338
    Motor_domain; Myosin and Kinesin motor domain.
  6. XM_011522239.1XP_011520541.1  

    Conserved Domains (3) summary
    pfam00225
    Location:90310
    Kinesin; Kinesin motor domain
    pfam05852
    Location:392514
    DUF848; Gammaherpesvirus protein of unknown function (DUF848)
    cl22853
    Location:1313
    Motor_domain; Myosin and Kinesin motor domain.
  7. XM_011522240.1XP_011520542.1  

    Conserved Domains (2) summary
    pfam05852
    Location:149271
    DUF848; Gammaherpesvirus protein of unknown function (DUF848)
    cl22853
    Location:170
    Motor_domain; Myosin and Kinesin motor domain.

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    69824574..69858736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)