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gmhA D-sedoheptulose 7-phosphate isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949134, updated on 4-Apr-2024

Summary

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Gene symbol
gmhA
Gene description
D-sedoheptulose 7-phosphate isomerase
Primary source
ASAP:ABE-0000751
Locus tag
b0222
See related
ECOCYC:G6106
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0223; lpcA; tfrA; yafI
Summary
Sedoheptulose 7-phosphate isomerase catalyzes the first committed step in the biosynthesis of a core component of lipopolysaccharide, the isomerization of D-sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate. [More information is available at EcoCyc: G6106].
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Genomic context

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Sequence:
NC_000913.3 (243543..244121)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene periplasmic chaperone, inhibitor of vertebrate C-type lysozyme Neighboring gene acyl-CoA dehydrogenase Neighboring gene putative glutamine amidotransferase YafJ Neighboring gene peptidoglycan meso-diaminopimelic acid protein amidase A Neighboring gene ribosome-dependent mRNA interferase toxin YafQ

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An in vitro screen of bacterial lipopolysaccharide biosynthetic enzymes identifies an inhibitor of ADP-heptose biosynthesis. De Leon GP, et al. Chem Biol, 2006 Apr. PMID 16632256
  2. Biosynthesis of inner core lipopolysaccharide in enteric bacteria identification and characterization of a conserved phosphoheptose isomerase. Brooke JS, et al. J Biol Chem, 1996 Feb 16. PMID 8631969
  3. Role of lipopolysaccharides in antibiotic resistance and bacteriophage adsorption of Escherichia coli K-12. Tamaki S, et al. J Bacteriol, 1971 Mar. PMID 4926688, Free PMC Article
  4. Conjugation deficient E. coli K12 F- mutants with heptose-less lipopolysaccharide. Havekes LM, et al. Mol Gen Genet, 1976 Jul 5. PMID 785207
  5. Study of the early response of Escherichia coli lpcA and ompF mutants to ciprofloxacin. Tyulenev AV, et al. Res Microbiol, 2022 Jul-Sep. PMID 35568342

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study of the early response of Escherichia coli lpcA and ompF mutants to ciprofloxacin.
    Title: Study of the early response of Escherichia coli lpcA and ompF mutants to ciprofloxacin.
  2. GmhA adopts two distinct conformations during isomerization through reorganization of quaternary structure.
    Title: Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables D-sedoheptulose 7-phosphate isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-sedoheptulose 7-phosphate isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate derivative binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within D-glycero-D-manno-heptose 7-phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in D-glycero-D-manno-heptose 7-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate derivative metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide core region biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
D-sedoheptulose 7-phosphate isomerase
NP_414757.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    243543..244121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414757.1 D-sedoheptulose 7-phosphate isomerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414757.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A895NW66
    Conserved Domains (1) summary
    PRK00414
    Location:1 → 192
    gmhA; D-sedoheptulose 7-phosphate isomerase
Nucleotide Protein
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