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    dfp fused 4'-phosphopantothenoylcysteine decarboxylase/phosphopantothenoylcysteine synthetase, FMN-binding [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949047, updated on 19-May-2013
    Gene symbol
    dfp
    Gene description
    fused 4'-phosphopantothenoylcysteine decarboxylase/phosphopantothenoylcysteine synthetase, FMN-binding
    Primary source
    EcoGene:EG10004
    Locus tag
    b3639
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655, old-name: Escherichia coli K12)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
    Also known as
    coaBC; ECK3629; JW5642
    Summary
    Dfp was originally identified as a flavoprotein affecting DNA synthesis and pantothenate metabolism. [More information is available at EcoGene: EG10004]. The dfp (coaBC) gene encodes a bifunctional protein that catalyzes two sequential reactions in the coenzyme A biosynthetic pathway . [More information is available at EcoCyc: EG10004].
    Sequence :
    NC_000913.2 (3810754..3811974)

    NC_000913.2Genomic Context describing neighboring genes Neighboring gene 50S ribosomal subunit protein L28 Neighboring gene conserved protein, UPF0758 family Neighboring gene deoxyuridinetriphosphatase Neighboring gene DNA-binding anti-FtsZ division inhibitor Neighboring gene orotate phosphoribosyltransferase

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Pantethine rescues phosphopantothenoylcysteine synthetase and phosphopantothenoylcysteine decarboxylase deficiency in Escherichia coli but not in Pseudomonas aeruginosa. Balibar CJ, et al. J Bacteriol, 2011 Jul. PMID 21551303.
    2. Selective inhibitors of bacterial phosphopantothenoylcysteine synthetase. Patrone JD, et al. J Am Chem Soc, 2009 Nov 18. PMID 19902973.
    3. Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Baba T, et al. Mol Syst Biol, 2006. PMID 16738554.
    4. Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Riley M, et al. Nucleic Acids Res, 2006. PMID 16397293.
    5. Interaction network containing conserved and essential protein complexes in Escherichia coli. Butland G, et al. Nature, 2005 Feb 3. PMID 15690043.

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The essentiality of coaBC, a single gene encoding a bifunctional protein catalyzing two consecutive steps in the CoA pathway converting 4'-phosphopantothenate to 4'-phosphopantetheine, was confirmed in Escherichia coli.
      Title: Pantethine rescues phosphopantothenoylcysteine synthetase and phosphopantothenoylcysteine decarboxylase deficiency in Escherichia coli but not in Pseudomonas aeruginosa.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Molecular characterization of lantibiotic-synthesizing enzyme EpiD reveals a function for bacterial Dfp proteins in coenzyme A biosynthesis.
    Submit: New GeneRIF Correction
    Products Interactant Other Gene Complex Source Pubs Description
    NP_418096   EcoCyc:CPLX0-341  EcoCyc  PubMed  

    Gene Ontology Provided by Univ. Wisconsin

    Process Evidence Code Pubs
    DNA-dependent DNA replication  
    coenzyme A biosynthetic process  
    Component Evidence Code Pubs
    cytoplasm  
    Names
    fused 4'-phosphopantothenoylcysteine decarboxylase/phosphopantothenoylcysteine synthetase, FMN-binding
    NP_418096.4
    • flavoprotein affecting synthesis of DNA and pantothenate metabolism

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.2

      Range
      3810754..3811974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418096.4 fused 4'-phosphopantothenoylcysteine decarboxylase/phosphopantothenoylcysteine synthetase, FMN-binding [Escherichia coli str. K-12 substr. MG1655]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P0ABQ0
      Conserved Domains (3) summary
      pfam02441
      Location:6 – 134
      Blast Score: 305
      Flavoprotein; Flavoprotein
      pfam04127
      Location:186 – 372
      Blast Score: 689
      DFP; DNA / pantothenate metabolism flavoprotein
      PRK05579
      Location:1 – 379
      Blast Score: 1470
      PRK05579; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
    Nucleotide Protein
    Heading Accession and Version
    genomic U00096.2 AAC76663.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • 3D structures
        3D structure of a gene
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • Nucleotide
        Link to related Nucleotide entry
      • Protein
        Link to related protein entry
      • Protein Clusters
        Related Protein Clusters
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • Taxonomy
        Link to related taxonomy entry

      Links to other resources

      General information

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