MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 [Homo sapiens] - Gene

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Summary

Official Symbol: MAPK8IP1provided by HGNC
Official Full Name: mitogen-activated protein kinase 8 interacting protein 1provided by HGNC
Primary source: HGNC:6882
See related: Ensembl:ENSG00000121653; HPRD:05223; MIM:604641; Vega:OTTHUMG00000134324
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IB1; JIP1; JIP-1; PRKM8IP
Summary: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

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Genomic context

Location :: 11p11.2

Sequence :: Chromosome: 11; NC_000011.9 (45907047..45928016)

See MAPK8IP1 in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that caspase 3-mediated cleavage of JIP1 scaffold proteins may represent an important mechanism for modulation of JNK signalling during apoptotic cell death.
Title: Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosis.
This review discusses the role of the JIP1 and the c-Jun NH(2)-terminal kinase pathway in the molecular pathogenesis of Alzheimer's and type 2 diabetes. JIP1 is a key regulator of the JNK pathway in neuronal and beta-cells.
Title: Role of the JNK-interacting protein 1/islet brain 1 in cell degeneration in Alzheimer disease and diabetes.
The pathological Tau/JIP1 interaction requires phosphorylation of Tau, and Tau competes with the physiological binding of JIP1 to kinesin light chain.
Title: Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.
Thyroid cancers are characterized by APP upregulation, increased membrane targeting of the APP ectodomain and significantly increased mRNA levels of the APP scaffold proteins JIP1, ShcA and Fe65.
Title: Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis.
the activity of JIP1-JNK complexes is downregulated by VRK2 in response to interleukin-1beta
Title: Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein.
Observational study of gene-disease association. (HuGE Navigator)
Title: Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease.
the phosphorylation of APP regulates the formation of a pAPP-JIP-1 complex that accumulates in neurites independent of nonphosphorylated APP
Title: Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1.
Binding of JIP1 and FEZ1 to Kinesin-1 is sufficient to activate the motor for microtubule binding and motility.
Title: Two binding partners cooperate to activate the molecular motor Kinesin-1.
Growth control of prostate cancer cells can be mediated through JNK/c-Jun pathway, but androgen responsiveness can be independent of this pathway; androgen independence in progressive prostate cancer may not occur through activation of this pathway.
Title: JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA).
High IGF II expression was followed by high expression of JIP-1 in testicular neoplasms.
Title: The JNK interacting protein JIP-1 and insulin like growth factor II genes are co-expressed in human embryonic tumours.

Submit: New GeneRIF Correction See all (21)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Diabetes mellitus, noninsulin-dependent

MIM: 125853

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_005447.1	NP_958817.1	APP	BIND	PubMed	JIP1 interacts with APP.
Q9UQF2	P31749	AKT1	HPRD	PubMed
Q9UQF2	P05067	APP	HPRD	PubMed
Q9UQF2	Q9BY84	DUSP16	HPRD	PubMed
Q9UQF2	Q07866	KLC1	HPRD	PubMed
Q9UQF2	Q07954	LRP1	HPRD	PubMed
Q9UQF2	P98164	LRP2	HPRD	PubMed
Q9UQF2	O14733	MAP2K7	HPRD	PubMed
Q9UQF2	Q16584	MAP3K11	HPRD	PubMed
Q9UQF2	O43283	MAP3K13	HPRD	PubMed
Q9UQF2	P45983	MAPK8	HPRD	PubMed
Q9UQF2	Q9UQF2	MAPK8IP1	HPRD	PubMed
Q9UQF2	Q13387	MAPK8IP2	HPRD	PubMed
Q9UQF2	Q9UPT6	MAPK8IP3	HPRD	PubMed
Q9UQF2	Q02962	PAX2	HPRD	PubMed
Q9UQF2	O94762	RECQL5	HPRD	PubMed
Q9UQF2	Rho guanine nucleotide exchange factor	RGNEF	HPRD	PubMed
Q9UQF2	P37840	SNCA	HPRD	PubMed
Q9UQF2	Q13009	TIAM1	HPRD	PubMed
BioGRID:114864	BioGRID:106710	AKT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114864	BioGRID:123321	DUSP16	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114864	BioGRID:110215	LRP1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:114864	BioGRID:110216	LRP2	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:114864	BioGRID:113579	LRP8	BioGRID	PubMed	Two-hybrid
BioGRID:114864	BioGRID:111595	MAP2K7	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114864	BioGRID:110440	MAP3K10	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114864	BioGRID:110442	MAP3K11	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114864	BioGRID:113566	MAP3K12	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114864	BioGRID:114614	MAP3K13	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114864	BioGRID:111585	MAPK8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114864	BioGRID:114864	MAPK8IP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114864	BioGRID:117086	MAPK8IP2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114864	BioGRID:116774	MAPK8IP3	BioGRID	PubMed	Reconstituted Complex
BioGRID:114864	BioGRID:111587	MAPK9	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114864	BioGRID:111110	PAX2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114864	BioGRID:114797	RECQL5	BioGRID	PubMed	Two-hybrid
BioGRID:114864	BioGRID:112930	TIAM1	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
JUN kinase binding	IEA Inferred from Electronic Annotation more info
MAP-kinase scaffold activity	IPI Inferred from Physical Interaction more info	PubMed
kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
mitogen-activated protein kinase kinase binding	IEA Inferred from Electronic Annotation more info
mitogen-activated protein kinase kinase kinase binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase inhibitor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
JUN phosphorylation	IEA Inferred from Electronic Annotation more info
anti-apoptosis	IEA Inferred from Electronic Annotation more info
negative regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
negative regulation of JUN kinase activity	IEA Inferred from Electronic Annotation more info
regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
signal transduction	IEA Inferred from Electronic Annotation more info
vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
axonal growth cone	IEA Inferred from Electronic Annotation more info
cell body	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	IEA Inferred from Electronic Annotation more info
dendrite	IEA Inferred from Electronic Annotation more info
dendritic growth cone	IEA Inferred from Electronic Annotation more info
dentate gyrus mossy fiber	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
membrane fraction	IEA Inferred from Electronic Annotation more info
mitochondrial membrane	IEA Inferred from Electronic Annotation more info
mitochondrion	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info
perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
synapse	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: C-Jun-amino-terminal kinase-interacting protein 1

Names: C-Jun-amino-terminal kinase-interacting protein 1; IB-1; islet-brain 1; JNK-interacting protein 1; PRKM8 interacting protein; JNK MAP kinase scaffold protein 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012153.1 RefSeqGene

Range

4846..25815

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_005456.3 → NP_005447.1 C-Jun-amino-terminal kinase-interacting protein 1

Status: REVIEWED

Source sequence(s)

AF007134, AF074091, BC068470, DB473314

Consensus CDS

CCDS7916.1

UniProtKB/TrEMBL

Q6NUQ9

UniProtKB/Swiss-Prot

Q9UQF2

Related

ENSP00000241014, OTTHUMP00000166057, ENST00000241014, OTTHUMT00000259405

Conserved Domains (1) summary

cl00273
Location:563 – 711
Blast Score: 536

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p5 Primary Assembly

Range

45907047..45928016

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

45613904..45634868

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC068385.9 (59594..80408)	None
genomic	CH471064.2	EAW68027.1
		EAW68028.1
mRNA	AB209720.1	BAD92957.1
mRNA	AF007134.1	AAC19150.1
mRNA	AF074091.1	AAD20443.1
mRNA	AK293637.1	BAH11553.1
mRNA	AK295942.1	BAG58726.1
mRNA	BC035920.1	None
mRNA	BC068470.1	AAH68470.1
mRNA	BI548334.1	None
mRNA	DB473314.1	None

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q59EU1	GenPept	UniProtKB/TrEMBL:Q59EU1
Q6NUQ9	GenPept	UniProtKB/TrEMBL:Q6NUQ9
Q9UQF2.1	GenPept	UniProtKB/Swiss-Prot:Q9UQF2