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galR DNA-binding transcriptional dual regulator GalR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947314, updated on 11-Apr-2024

Summary

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Gene symbol
galR
Gene description
DNA-binding transcriptional dual regulator GalR
Primary source
ASAP:ABE-0009307
Locus tag
b2837
See related
ECOCYC:EG10364
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2835; Rgal
Summary
The "Galactose repressor," GalR, is a DNA-binding transcription factor that represses transcription of the operons involved in transport and catabolism of D-galactose . [More information is available at EcoCyc: EG10364].
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Genomic context

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Sequence:
NC_000913.3 (2976599..2977630)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene diaminopimelate decarboxylase Neighboring gene DNA-binding transcriptional dual regulator LysR Neighboring gene amino acid racemase YgeA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in transcriptional regulators allow selective engineering of signal integration logic. Semsey S. mBio, 2014 Jun 24. PMID 24961691, Free PMC Article
  2. Galactose repressor mediated intersegmental chromosomal connections in Escherichia coli. Qian Z, et al. Proc Natl Acad Sci U S A, 2012 Jul 10. PMID 22733746, Free PMC Article
  3. Three-stage regulation of the amphibolic gal operon: from repressosome to GalR-free DNA. Semsey S, et al. J Mol Biol, 2006 Apr 28. PMID 16524589
  4. Gal repressor-operator-HU ternary complex: pathway of repressosome formation. Roy S, et al. Biochemistry, 2005 Apr 12. PMID 15807530
  5. GalR represses galP1 by inhibiting the rate-determining open complex formation through RNA polymerase contact: a GalR negative control mutant. Roy S, et al. J Mol Biol, 2004 Nov 26. PMID 15533432

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Single amino acid substitutions in GalR affects transcriptional regulation and signal integration logic at engineered promoters.
    Title: Mutations in transcriptional regulators allow selective engineering of signal integration logic.
  2. analysis of galactose repressor mediated intersegmental chromosomal connections in Escherichia coli
    Title: Galactose repressor mediated intersegmental chromosomal connections in Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in galactose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator GalR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2976599..2977630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417314.1 DNA-binding transcriptional dual regulator GalR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417314.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AA87G649
    Conserved Domains (1) summary
    PRK10727
    Location:1 → 343
    PRK10727; HTH-type transcriptional regulator GalR
Nucleotide Protein
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