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AKAP6 A-kinase anchoring protein 6 [ Homo sapiens (human) ]

Gene ID: 9472, updated on 8-May-2016
Official Symbol
AKAP6provided by HGNC
Official Full Name
A-kinase anchoring protein 6provided by HGNC
Primary source
HGNC:HGNC:376
See related
Ensembl:ENSG00000151320 HPRD:05257; MIM:604691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADAP6; PRKA6; mAKAP; ADAP100; AKAP100
Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008]
Orthologs
Location:
14q12
Exon count:
21
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (32329273..32833999)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (32798479..33302268)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene HERV-FRD provirus ancestral Env polyprotein pseudogene Neighboring gene KIAA1143 pseudogene Neighboring gene MT-CO1 pseudogene 2 Neighboring gene uncharacterized LOC105370441 Neighboring gene neuronal PAS domain protein 3 Neighboring gene uncharacterized LOC105370443 Neighboring gene uncharacterized LOC105370442

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
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NHGRI GWA Catalog
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NHGRI GWA Catalog
The genetic architecture of economic and political preferences.
NHGRI GWA Catalog
  • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
    G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0311, MGC165020

Gene Ontology Provided by GOA

Function Evidence Code Pubs
adenylate cyclase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein anchor ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex scaffold ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase A binding NAS
Non-traceable Author Statement
more info
PubMed 
protein kinase A binding TAS
Traceable Author Statement
more info
PubMed 
protein kinase A regulatory subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
action potential IC
Inferred by Curator
more info
PubMed 
cAMP-mediated signaling NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to cytokine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of cAMP biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of NFAT protein import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of calcineurin-NFAT signaling cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cell growth involved in cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of delayed rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphatase type 2B activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of release of sequestered calcium ion into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ryanodine-sensitive calcium-release channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein targeting NAS
Non-traceable Author Statement
more info
PubMed 
regulation of membrane repolarization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein kinase A signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IC
Inferred by Curator
more info
 
Component Evidence Code Pubs
T-tubule ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
caveola ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
intercalated disc ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
junctional sarcoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
A-kinase anchor protein 6
Names
A kinase (PRKA) anchor protein 6
A-kinase anchor protein 100 kDa
AKAP 100
AKAP-6
protein kinase A anchoring protein 6
protein kinase A-anchoring protein 6

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004274.4NP_004265.3  A-kinase anchor protein 6

    See identical proteins and their annotated locations for NP_004265.3

    Status: REVIEWED

    Source sequence(s)
    BC137232, BC150288, BP230135, U17195
    Consensus CDS
    CCDS9644.1
    UniProtKB/Swiss-Prot
    Q13023
    UniProtKB/TrEMBL
    B2RP22
    Related
    ENSP00000280979, OTTHUMP00000178791, ENST00000280979, OTTHUMT00000276617
    Conserved Domains (2) summary
    cd00176
    Location:9611189
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02488
    Location:784887
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    32329273..32833999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268219.3XP_005268276.1  

    Conserved Domains (2) summary
    cd00176
    Location:9621190
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02488
    Location:784888
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  2. XM_011537379.1XP_011535681.1  

    See identical proteins and their annotated locations for XP_011535681.1

    Conserved Domains (1) summary
    cd00176
    Location:34262
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  3. XM_011537378.1XP_011535680.1  

    Conserved Domains (1) summary
    cd00176
    Location:57285
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  4. XM_011537380.1XP_011535682.1  

    See identical proteins and their annotated locations for XP_011535682.1

    Conserved Domains (1) summary
    cd00176
    Location:34262
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  5. XM_011537382.1XP_011535684.1  

    See identical proteins and their annotated locations for XP_011535684.1

    Conserved Domains (1) summary
    cl02488
    Location:1212
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  6. XM_011537381.1XP_011535683.1  

    See identical proteins and their annotated locations for XP_011535683.1

    Conserved Domains (1) summary
    cl02488
    Location:1212
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  7. XM_011537383.1XP_011535685.1  

    Conserved Domains (1) summary
    cl02488
    Location:10184
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    32798120..33300973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)