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hypE carbamoyl dehydratase HypE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947182, updated on 4-Apr-2024

Summary

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Gene symbol
hypE
Gene description
carbamoyl dehydratase HypE
Primary source
ASAP:ABE-0008967
Locus tag
b2730
See related
ECOCYC:EG10487
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2725; hydB
Summary
HypF adds the C-terminal thiocarbamate to HypE. [More information is available at EcoGene: EG10487]. HypE is one of the hydrogenase maturation proteins required for the assembly of the CN ligand of the NiFe metal center of hydrogenase 1, 2 and 3. [More information is available at EcoCyc: EG10487].
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Genomic context

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Sequence:
NC_000913.3 (2853254..2854264)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase 3 nickel incorporation protein HypA Neighboring gene hydrogenase isoenzymes nickel incorporation protein HypB Neighboring gene hydrogenase maturation factor HypC Neighboring gene Fe-(CN)2CO cofactor assembly scaffold protein HypD Neighboring gene DNA-binding transcriptional activator FhlA Neighboring gene protein YgbA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Extracellular iron reduction is mediated in part by neutral red and hydrogenase in Escherichia coli. McKinlay JB, et al. Appl Environ Microbiol, 2004 Jun. PMID 15184145, Free PMC Article
  2. Biochemical and genetic analysis of hydrogen metabolism in Escherichia coli: the hydB gene. Sankar P, et al. J Bacteriol, 1988 Dec. PMID 2848007, Free PMC Article
  3. Identification of an Isothiocyanate on the HypEF Complex Suggests a Route for Efficient Cyanyl-Group Channeling during [NiFe]-Hydrogenase Cofactor Generation. Stripp ST, et al. PLoS One, 2015. PMID 26186649, Free PMC Article
  4. Structure of [NiFe] hydrogenase maturation protein HypE from Escherichia coli and its interaction with HypF. Rangarajan ES, et al. J Bacteriol, 2008 Feb. PMID 18065529, Free PMC Article
  5. HypF, a carbamoyl phosphate-converting enzyme involved in [NiFe] hydrogenase maturation. Paschos A, et al. J Biol Chem, 2002 Dec 20. PMID 12377778

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein-containing complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of ATPase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
carbamoyl dehydratase HypE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2853254..2854264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417210.2 carbamoyl dehydratase HypE [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417210.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7D7DLS8, A0AA90J823
    Conserved Domains (1) summary
    TIGR02124
    Location:15 → 336
    hypE; hydrogenase expression/formation protein HypE
Nucleotide Protein
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Other Literature Sources
Molecular Biology Databases