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EIF4E2 eukaryotic translation initiation factor 4E family member 2 [ Homo sapiens (human) ]

Gene ID: 9470, updated on 8-May-2016
Official Symbol
EIF4E2provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4E family member 2provided by HGNC
Primary source
HGNC:HGNC:3293
See related
Ensembl:ENSG00000135930 HPRD:05798; MIM:605895; Vega:OTTHUMG00000133256
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
4EHP; IF4e; 4E-LP; EIF4EL3
Orthologs
Location:
2q37.1
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (232550057..232583645)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (233414762..233448354)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cholinergic receptor nicotinic delta subunit Neighboring gene cholinergic receptor nicotinic gamma subunit Neighboring gene microRNA 5001 Neighboring gene tigger transposable element derived 1 Neighboring gene uncharacterized LOC105373929 Neighboring gene EF-hand domain family member D1 Neighboring gene GRB10 interacting GYF protein 2 Neighboring gene eukaryotic translation elongation factor 1 beta 2 pseudogene 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel.
NHGRI GWA Catalog
  • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
    Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
    HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
  • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
    ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Longevity regulating pathway, organism-specific biosystem (from KEGG)
    Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • eIF4F complex, organism-specific biosystem (from KEGG)
    eIF4F complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • eIF4F complex, conserved biosystem (from KEGG)
    eIF4F complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystem
    mTOR signaling pathway
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystem
    mTOR signaling pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ23586

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA cap binding TAS
Traceable Author Statement
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation factor activity, RNA binding TAS
Traceable Author Statement
more info
PubMed 
translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
mRNA cap binding complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
eukaryotic translation initiation factor 4E type 2
Names
eIF-4E type 2
eIF4E-like cap-binding protein
eIF4E-like protein 4E-LP
eukaryotic translation initiation factor 4E homologous protein
eukaryotic translation initiation factor 4E-like 3
mRNA cap-binding protein type 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276336.1NP_001263265.1  eukaryotic translation initiation factor 4E type 2 isoform C

    See identical proteins and their annotated locations for NP_001263265.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (C) has a distinct C-terminus and is shorter than isoform A.
    Source sequence(s)
    AB209519, AK027239, BG029258, DA201209, DA592245, DA992544
    Consensus CDS
    CCDS63159.1
    UniProtKB/Swiss-Prot
    O60573
    UniProtKB/TrEMBL
    Q59FE1
    Related
    ENSP00000386996, OTTHUMP00000203680, ENST00000409098, OTTHUMT00000330694
    Conserved Domains (1) summary
    pfam01652
    Location:55217
    IF4E; Eukaryotic initiation factor 4E
  2. NM_001276337.1NP_001263266.1  eukaryotic translation initiation factor 4E type 2 isoform D

    See identical proteins and their annotated locations for NP_001263266.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (D) has a distinct C-terminus and is shorter than isoform A.
    Source sequence(s)
    AB209519, AK027239, BG029258, CD684451, DA201209, DA592245, DA992544
    Consensus CDS
    CCDS74671.1
    UniProtKB/TrEMBL
    B9A023, Q59FE1
    Related
    ENSP00000386983, OTTHUMP00000203684, ENST00000409394, OTTHUMT00000330700
    Conserved Domains (1) summary
    pfam01652
    Location:46172
    IF4E; Eukaryotic initiation factor 4E
  3. NM_001282958.1NP_001269887.1  eukaryotic translation initiation factor 4E type 2 isoform B

    See identical proteins and their annotated locations for NP_001269887.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 3' exon structure and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (B) has a distinct C-terminus and is shorter than isoform A.
    Source sequence(s)
    AB209519, AK027239, BG029258, BG913475, DA201209, DA408433, DA592245, DA992544
    Consensus CDS
    CCDS63158.1
    UniProtKB/TrEMBL
    B8ZZ50, Q59FE1
    Related
    ENSP00000387336, OTTHUMP00000203681, ENST00000409514, OTTHUMT00000330695
    Conserved Domains (1) summary
    pfam01652
    Location:55217
    IF4E; Eukaryotic initiation factor 4E
  4. NM_004846.3NP_004837.1  eukaryotic translation initiation factor 4E type 2 isoform A

    See identical proteins and their annotated locations for NP_004837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (A).
    Source sequence(s)
    BC005874, BM018173, DA992544
    Consensus CDS
    CCDS2496.1
    UniProtKB/Swiss-Prot
    O60573
    UniProtKB/TrEMBL
    Q53RG0
    Related
    ENSP00000258416, OTTHUMP00000164355, ENST00000258416, OTTHUMT00000257033
    Conserved Domains (1) summary
    pfam01652
    Location:55217
    IF4E; Eukaryotic initiation factor 4E

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    232550057..232583645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246975.2XP_005247032.1  

    See identical proteins and their annotated locations for XP_005247032.1

    UniProtKB/TrEMBL
    B8ZZL3
    Related
    ENSP00000386424, OTTHUMP00000203687, ENST00000409322, OTTHUMT00000330706
    Conserved Domains (1) summary
    pfam01652
    Location:46172
    IF4E; Eukaryotic initiation factor 4E
  2. XM_011512206.1XP_011510508.1  

    See identical proteins and their annotated locations for XP_011510508.1

    Related
    ENSP00000390904, OTTHUMP00000203685, ENST00000454501, OTTHUMT00000330702
    Conserved Domains (1) summary
    pfam01652
    Location:50212
    IF4E; Eukaryotic initiation factor 4E

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    233421395..233454439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)