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CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 [ Homo sapiens (human) ]

Gene ID: 9469, updated on 25-Jul-2015
Official Symbol
CHST3provided by HGNC
Official Full Name
carbohydrate (chondroitin 6) sulfotransferase 3provided by HGNC
Primary source
HGNC:HGNC:1971
See related
Ensembl:ENSG00000122863; HPRD:07052; MIM:603799; Vega:OTTHUMG00000018431
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSD; C6ST; C6ST1
Summary
This gene encodes an enzyme which catalyzes the sulfation of chondroitin, a proteoglycan found in the extracellular matrix and most cells which is involved in cell migration and differentiation. Mutations in this gene are associated with spondylepiphyseal dysplasia and humerospinal dysostosis. [provided by RefSeq, Mar 2009]
Orthologs
See CHST3 in Epigenomics, MapViewer
Location:
10q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (71964362..72013564)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (73724120..73773322)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene cadherin-related 23 Neighboring gene microRNA 7152 Neighboring gene RNA, U7 small nuclear 38 pseudogene Neighboring gene prosaposin Neighboring gene sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 Neighboring gene activating signal cointegrator 1 complex subunit 1 Neighboring gene ribosomal protein L15 pseudogene 14

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Sulfate is linked to the carbohydrate chains of HIV-1 glycoproteins gp160, gp120, and gp41 during the endoplasmic reticulum to Golgi transport of the glycoproteins PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chondroitin 6-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
proteoglycan sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
sulfotransferase activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
carbohydrate sulfotransferase 3
Names
C6ST-1
GST-0
chondroitin 6-O-sulfotransferase 1
galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0
NP_004264.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012635.1 RefSeqGene

    Range
    5001..54203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004273.4NP_004264.2  carbohydrate sulfotransferase 3

    See identical proteins and their annotated locations for NP_004264.2

    Status: REVIEWED

    Source sequence(s)
    AB017915, AC022392, AI041015
    Consensus CDS
    CCDS7312.1
    UniProtKB/Swiss-Prot
    Q7LGC8
    Related
    ENSP00000362207, OTTHUMP00000019779, ENST00000373115, OTTHUMT00000048563
    Conserved Domains (1) summary
    pfam00685
    Location:269452
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    71964362..72013564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718075.2XP_006718138.1  

    See identical proteins and their annotated locations for XP_006718138.1

    UniProtKB/Swiss-Prot
    Q7LGC8
    Conserved Domains (1) summary
    pfam00685
    Location:269452
    Sulfotransfer_1; Sulfotransferase domain
  2. XM_011540369.1XP_011538671.1  

    See identical proteins and their annotated locations for XP_011538671.1

    UniProtKB/Swiss-Prot
    Q7LGC8
    Conserved Domains (1) summary
    pfam00685
    Location:269452
    Sulfotransfer_1; Sulfotransferase domain

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    74006249..74055464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)