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cheZ chemotaxis protein CheZ [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946392, updated on 6-Oct-2023

Summary

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Gene symbol
cheZ
Gene description
chemotaxis protein CheZ
Primary source
ASAP:ABE-0006278
Locus tag
b1881
See related
ECOCYC:EG10151
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1882
Summary
Polar localization is dependent on CheA-short. [More information is available at EcoGene: EG10151]. CheZ is a cytosolic phosphatase which functions in the chemotaxis signal transduction complex. [More information is available at EcoCyc: EG10151].
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Genomic context

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Sequence:
NC_000913.3 (1966393..1967037, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene flagellar protein FlhE Neighboring gene flagellar biosynthesis protein FlhA Neighboring gene flagellar biosynthesis protein FlhB Neighboring gene chemotaxis protein CheY Neighboring gene protein-glutamate methylesterase/protein glutamine deamidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Blue Light-Directed Cell Migration, Aggregation, and Patterning. Zhang J, et al. J Mol Biol, 2020 May 1. PMID 32247761
  2. Escherichia coli Remodels the Chemotaxis Pathway for Swarming. Partridge JD, et al. mBio, 2019 Mar 19. PMID 30890609, Free PMC Article
  3. Differential affinity and catalytic activity of CheZ in E. coli chemotaxis. van Albada SB, et al. PLoS Comput Biol, 2009 May. PMID 19424426, Free PMC Article
  4. Guiding bacteria with small molecules and RNA. Topp S, et al. J Am Chem Soc, 2007 May 30. PMID 17480075, Free PMC Article
  5. Isolation and characterization of nonchemotactic CheZ mutants of Escherichia coli. Boesch KC, et al. J Bacteriol, 2000 Jun. PMID 10852888, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Blue Light-Directed Cell Migration, Aggregation, and Patterning.
    Title: Blue Light-Directed Cell Migration, Aggregation, and Patterning.
  2. The suitability for FRET analysis as well as functionality of fusions with SNAP- and HaloTag could be demonstrated by studying the transient interaction between chemotaxis response regulator CheY and its phosphatase CheZ
    Title: A gateway-based system for fast evaluation of protein-protein interactions in bacteria.
  3. Amino acid substitutions distant from the active site can affect CheZ catalytic activity and CheYp binding, perhaps via the propagation of structural or dynamic perturbations through a helical bundle.
    Title: Action at a distance: amino acid substitutions that affect binding of the phosphorylated CheY response regulator and catalysis of dephosphorylation can be far from the CheZ phosphatase active site.
  4. Specific CheA-short (CheA(S)) residues, L123 and L126, were identified as critical for CheZ binding.
    Title: The CheZ binding interface of CheAS is located in alpha-helix E.
  5. simulations suggest that dynamic CheZ localization will sharpen cellular responses to chemoeffectors, increase the range of detectable ligand concentrations, and make adaptation more precise and robust
    Title: Changing cellular location of CheZ predicted by molecular simulations.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in archaeal or bacterial-type flagellum-dependent cell motility IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within bacterial-type flagellum-dependent swarming motility IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of bacterial-type flagellum-dependent cell motility NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of chemotaxis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in bacterial-type flagellum IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of methyl accepting chemotaxis protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chemotaxis protein CheZ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1966393..1967037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416395.1 chemotaxis protein CheZ [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416395.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9A9E9
    Conserved Domains (1) summary
    PRK11166
    Location:1 → 214
    PRK11166; chemotaxis regulator CheZ; Provisional
Nucleotide Protein
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