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tktB transketolase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945865, updated on 23-Nov-2023

Summary

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Gene symbol
tktB
Gene description
transketolase 2
Primary source
ASAP:ABE-0008117
Locus tag
b2465
See related
ECOCYC:EG12100
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2460
Summary
Consistently co-purifies with the degradosome. [More information is available at EcoGene: EG12100]. TktB is responsible for the minor transketolase activity in Escherichia coli, and TktA is responsible for the major transketolase activity . [More information is available at EcoCyc: EG12100].
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Genomic context

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Sequence:
NC_000913.3 (2579636..2581639)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) Neighboring gene transaldolase A Neighboring gene DUF1176 domain-containing protein YpfG Neighboring gene GDP-mannose hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Robustness analysis of the Escherichia coli metabolic network. Edwards JS, et al. Biotechnol Prog, 2000 Nov-Dec. PMID 11101318
  2. Enzyme-catalysed carbon-carbon bond formation: large-scale production of Escherichia coli transketolase. Hobbs GR, et al. J Biotechnol, 1996 Feb 28. PMID 9147449
  3. In situ product removal from E. coli transketolase-catalyzed biotransformations. Chauhan RP, et al. Ann N Y Acad Sci, 1996 Oct 12. PMID 8958111
  4. Production and modification of E. coli transketolase for large-scale biocatalysis. French C, et al. Ann N Y Acad Sci, 1996 Oct 12. PMID 8958067
  5. Transketolase A of Escherichia coli K12. Purification and properties of the enzyme from recombinant strains. Sprenger GA, et al. Eur J Biochem, 1995 Jun 1. PMID 7607225

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. tktB is a transcriptional target of ppGpp; activation of tktB transcription by ppGpp occurs both through the modulation of RpoS levels and independent of RpoS.
    Title: Synthetic growth phenotypes of Escherichia coli lacking ppGpp and transketolase A (tktA) are due to ppGpp-mediated transcriptional regulation of tktB.
  2. stationary growth-dependent expression mediated by RpoS action
    Title: RpoS-mediated growth-dependent expression of the Escherichia coli tkt genes encoding transketolases isoenzymes.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transketolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transketolase activity IEA
Inferred from Electronic Annotation
more info
  
enables transketolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transketolase or transaldolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in pentose-phosphate shunt IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transketolase 2
NP_416960.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2579636..2581639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416960.1 transketolase 2 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416960.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2W6PC01, A0A3Z6G4Q3, A0A8T6BJN4, F4V4I7
    Conserved Domains (1) summary
    PRK12753
    Location:1 → 662
    PRK12753; transketolase; Reviewed
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials