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    CD33 CD33 molecule [ Homo sapiens ]

    Gene ID: 945, updated on 11-May-2012

    Summary

    Official Symbol
    CD33provided by HGNC
    Official Full Name
    CD33 moleculeprovided by HGNC
    Primary source
    HGNC:1659
    See related
    Ensembl:ENSG00000105383; HPRD:01165; MIM:159590
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p67; SIGLEC3; SIGLEC-3; FLJ00391

    Genomic context

    Location :
    19q13.3
    Sequence :
    Chromosome: 19; NC_000019.9 (51728335..51743274)
    See CD33 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene sialic acid binding Ig-like lectin 21, pseudogene Neighboring gene sialic acid binding Ig-like lectin 22, pseudogene Neighboring gene chromosome 19 open reading frame 75 Neighboring gene sialic acid binding Ig-like lectin 23, pseudogene Neighboring gene sialic acid binding Ig-like lectin 24, pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr downregulates CD33 expression in PBMC PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P20138 Q06124 PTPN11    HPRD  PubMed  
    P20138 P29350 PTPN6    HPRD  PubMed  
    P20138 P12931 SRC    HPRD  PubMed  
    BioGRID:107383 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107383 BioGRID:111745 PTPN11    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107383 BioGRID:111742 PTPN6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107383 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    sugar binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    myeloid cell surface antigen CD33
    Names
    myeloid cell surface antigen CD33
    gp67
    CD33 antigen (gp67)
    sialic acid binding Ig-like lectin 3
    sialic acid-binding Ig-like lectin 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082618.1NP_001076087.1  myeloid cell surface antigen CD33 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2, also known as CD33m), compared to isoform 1.
      Source sequence(s)
      AW007749, AY162464, BP303860
      Consensus CDS
      CCDS46157.1
      UniProtKB/TrEMBL
      C9JEN7
      Related
      ENSP00000410126, ENST00000421133
      Conserved Domains (1) summary
      cl11960
      Location:1891
      Blast Score: 91
      Ig; Immunoglobulin domain
    2. NM_001177608.1NP_001171079.1  myeloid cell surface antigen CD33 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK304810, AK309558, BP295158
      Consensus CDS
      CCDS54299.1
      UniProtKB/TrEMBL
      B4E3P8
      UniProtKB/TrEMBL
      F8WAL2
      Related
      ENSP00000375673, ENST00000391796
      Conserved Domains (2) summary
      pfam07686
      Location:24136
      Blast Score: 137
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:23139
      Blast Score: 354
      Ig; Immunoglobulin domain
    3. NM_001772.3NP_001763.3  myeloid cell surface antigen CD33 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as CD33M.
      Source sequence(s)
      AW007749, BC028152, BP303860
      Consensus CDS
      CCDS33084.1
      UniProtKB/Swiss-Prot
      P20138
      UniProtKB/TrEMBL
      Q546G0
      Related
      ENSP00000262262, ENST00000262262
      Conserved Domains (2) summary
      pfam07686
      Location:24136
      Blast Score: 137
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:23139
      Blast Score: 358
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      51728335..51743274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      48061383..48076328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC063977.6 (104268..119177) None
    genomic AJ491319.1 CAD36509.1
    genomic AY040541.1 AAK83654.1
    genomic CH471135.1 EAW71994.1
      EAW71995.1
      EAW71996.1
    genomic JA738577.1 CCF76941.1
    genomic JA738579.1 CCF76942.1
    mRNA AK090470.1 BAC03451.1
    mRNA AK293934.1 BAG57312.1
    mRNA AK304810.1 BAG65560.1
    mRNA AK309558.1 None
    mRNA AW007749.1 None
    mRNA AY162464.1 AAO26206.1
    mRNA BC028152.1 AAH28152.1
    mRNA BP295158.1 None
    mRNA BP303860.1 None
    mRNA CA426969.1 None
    mRNA CA748646.1 None
    mRNA M23197.1 AAA51948.1
    other-genetic DQ891726.2 ABM82652.1
    other-genetic DQ894903.2 ABM85829.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20138.2 GenPept UniProtKB/Swiss-Prot:P20138
    Q546G0 GenPept UniProtKB/TrEMBL:Q546G0
    Q8NF11 GenPept UniProtKB/TrEMBL:Q8NF11

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