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thpR RNA 2',3'-cyclic phosphodiesterase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944848, updated on 6-Oct-2023

Summary

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Gene symbol
thpR
Gene description
RNA 2',3'-cyclic phosphodiesterase
Primary source
ASAP:ABE-0000505
Locus tag
b0147
See related
ECOCYC:EG12330
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0146; ligT; yadP
Summary
LigT reversibly ligates RNA to form 2'-5' linkages. [More information is available at EcoCyc: EG12330].
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Genomic context

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Sequence:
NC_000913.3 (161501..162031, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene RNA polymerase-binding transcription factor DksA Neighboring gene sugar fermentation stimulation protein A Neighboring gene RNA-dependent NTPase HrpB Neighboring gene PBP1Bgamma;peptidoglycan glycosyltransferase/peptidoglycan DD-transpeptidase MrcB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and mechanism of E. coli RNA 2',3'-cyclic phosphodiesterase. Remus BS, et al. RNA, 2014 Nov. PMID 25239919, Free PMC Article
  2. RNA ligase in bacteria: formation of a 2',5' linkage by an E. coli extract. Greer CL, et al. Cell, 1983 Jul. PMID 6347395
  3. Biophysical characterization of cyclic nucleotide phosphodiesterases. Hofmann A, et al. Biochem Biophys Res Commun, 2002 Mar 8. PMID 11866446
  4. DNA and RNA ligases: structural variations and shared mechanisms. Pascal JM. Curr Opin Struct Biol, 2008 Feb. PMID 18262407
  5. Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region. Fujita N, et al. Nucleic Acids Res, 1994 May 11. PMID 8202364, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: The 2'-5' RNA ligase of Escherichia coli. Purification, cloning, and genomic disruption.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2'-5'-RNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2'-5'-RNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA 2',3'-cyclic phosphodiesterase
NP_414689.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    161501..162031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414689.4 RNA 2',3'-cyclic phosphodiesterase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414689.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8R2Y7
    Conserved Domains (1) summary
    PRK15124
    Location:1 → 176
    PRK15124; RNA 2',3'-cyclic phosphodiesterase
Nucleotide Protein
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