TP53INP1 tumor protein p53 inducible nuclear protein 1 [Homo sapiens] - Gene

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Summary

Official Symbol: TP53INP1provided by HGNC
Official Full Name: tumor protein p53 inducible nuclear protein 1provided by HGNC
Primary source: HGNC:18022
See related: Ensembl:ENSG00000164938; HPRD:09367; MIM:606185; Vega:OTTHUMG00000164697
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SIP; Teap; p53DINP1; TP53DINP1; TP53INP1A; TP53INP1B; FLJ22139; DKFZp434M1317

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Genomic context

Location :: 8q22

Sequence :: Chromosome: 8; NC_000008.10 (95938200..95961615, complement)

See TP53INP1 in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In normal prostate tissues, TP53INP1 is only expressed in prostate basal cells. There is a de novo TP53INP1 expression in prostate luminal cells in inflammatory prostate tissues, high grade PIN lesions and in prostate cancer.
Title: TP53INP1 overexpression in prostate cancer correlates with poor prognostic factors and is predictive of biological cancer relapse.
This novel TP53INP1 activity on the regulation of SPARC expression could explain in part its tumor suppressor function in pancreatic adenocarcinoma by modulating cellular spreading during the metastatic process
Title: TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression.
TP53INP1 is a tumor suppressor in esophageal squamous cell carcinoma (ESCC0; c-Myc-mediated DNA methylation-associated silencing of TP53INP1 contributed to the pathogenesis of human ESCC.
Title: c-Myc inhibits TP53INP1 expression via promoter methylation in esophageal carcinoma.
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
Title: Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
findings implicate a miR-93/miR-130b-TP53INP1 axis that affects the proliferation and survival of HTLV-1-infected/transformed cells
Title: Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1.
P53DINP1 mRNA expression promotes Ser46 phophlrylation of p53, without finding a significant correlation between mRNA expression of p53AIP1.
Title: Insights in gastric carcinogenesis from Helicobacter pylori infection.
The p53DINP1 mRna expression in the antral mucosa was significantly lower in the gastric cancer patients than in the chronic gastritis patients.
Title: Difference of p53AIP1 mRNA expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with Helicobacter pylori.
TP53INP1s and HIPK2 could be partners in regulating p53 activity.
Title: TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.
TP53INP1s are functionally associated with p73 to regulate cell cycle progression and apoptosis.
Title: TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity.
Data show that induction of the stress-induced proteins (SIPs) SIP18 and SIP27, in human- and mouse-derived cell lines, is absent from cells with deleted, mutated or inactive p53, suggesting that regulation of SIP gene expression is dependent on p53.
Title: P53-dependent expression of the stress-induced protein (SIP).

Submit: New GeneRIF Correction See all (14)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000008.9	NP_005216.1	E2F1	BIND	PubMed	E2F1 interacts with the TP53INP1 promoter.
NC_000008.9	NP_004082.1	E2F2	BIND	PubMed	E2F2 interacts with the TP53INP1 promoter.
NC_000008.9	NP_001940.1	E2F3	BIND	PubMed	E2F3 interacts with the TP53INP1 promoter.
NC_000008.9	NP_001941.2	E2F4	BIND	PubMed	E2F4 interacts with the TP53INP1 promoter.
Q96A56	Q9H2X6	HIPK2	HPRD	PubMed
Q96A56	P04637	TP53	HPRD	PubMed
BioGRID:125152	BioGRID:118815	HIPK2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:125152	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

Process	Evidence Code	Pubs
apoptotic process	IEA Inferred from Electronic Annotation more info
cell cycle arrest	IEA Inferred from Electronic Annotation more info
induction of apoptosis	IEA Inferred from Electronic Annotation more info
response to stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
PML body	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: tumor protein p53-inducible nuclear protein 1

Names: tumor protein p53-inducible nuclear protein 1; p53-inducible p53DINP1; stress-induced protein; p53-dependent damage-inducible nuclear protein 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135733.1 → NP_001129205.1 tumor protein p53-inducible nuclear protein 1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon compared to variant 1 that has an in-frame stop codon in it. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AB017926, AF409114, DB086880

Consensus CDS

CCDS47899.1

UniProtKB/Swiss-Prot

Q96A56

Related

ENSP00000390063, OTTHUMP00000227253, ENST00000448464, OTTHUMT00000379817
NM_033285.3 → NP_150601.1 tumor protein p53-inducible nuclear protein 1 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AB017926, AF409115, DB086880

Consensus CDS

CCDS6265.1

UniProtKB/Swiss-Prot

Q96A56

Related

ENSP00000344215, OTTHUMP00000227254, ENST00000342697, OTTHUMT00000379818

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p5 Primary Assembly

Range

95938200..95961615, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

91146079..91169530, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB062056.1	BAB62151.1
		BAB62152.1
genomic	AC087752.12 (50772..74162)	None
genomic	CH471060.1	EAW91739.1
		EAW91740.1
		EAW91741.1
mRNA	AB017926.1	BAB62149.1
mRNA	AB017927.1	BAB62150.1
mRNA	AF409114.1	AAL04513.1
mRNA	AF409115.1	AAL04514.1
mRNA	AK025792.1	None
mRNA	AK123608.1	None
mRNA	AK125880.1	None
mRNA	AK130074.1	None
mRNA	AK315071.1	BAG37542.1
mRNA	AL133074.1	None
mRNA	AL833652.1	None
mRNA	BC074813.2	AAH74813.1
mRNA	BC074868.2	AAH74868.1
mRNA	DB086880.1	None