CRIPT cysteine-rich PDZ-binding protein [Homo sapiens] - Gene

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Summary

Official Symbol: CRIPTprovided by HGNC
Official Full Name: cysteine-rich PDZ-binding proteinprovided by HGNC
Primary source: HGNC:14312
Locus tag: HSPC139
See related: Ensembl:ENSG00000119878; HPRD:05208; MIM:604594; Vega:OTTHUMG00000128815
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSPC139

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Genomic context

Location :: 2p21

Sequence :: Chromosome: 2; NC_000002.11 (46844325..46852881)

See CRIPT in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.

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Products	Interactant	Other Gene	Source	Pubs	Description
Postsynaptic protein CRIPT	Q12959	DLG1	HPRD	PubMed
Postsynaptic protein CRIPT	Q15700	DLG2	HPRD	PubMed
Postsynaptic protein CRIPT	Q92796	DLG3	HPRD	PubMed
Postsynaptic protein CRIPT	P78352	DLG4	HPRD	PubMed
Postsynaptic protein CRIPT	Q8NI35	INADL	HPRD	PubMed
Postsynaptic protein CRIPT	P07437	TUBB	HPRD	PubMed
Postsynaptic protein CRIPT	Q9NRR5	UBQLN4	HPRD	PubMed
BioGRID:114812	BioGRID:108083	DLG1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114812	BioGRID:108085	DLG3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114812	BioGRID:108086	DLG4	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
PDZ domain binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cytoplasmic microtubule organization	IEA Inferred from Electronic Annotation more info
establishment of protein localization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell junction	IEA Inferred from Electronic Annotation more info
cell projection	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
dendritic shaft	IEA Inferred from Electronic Annotation more info
dendritic spine	IEA Inferred from Electronic Annotation more info
neuronal cell body	IEA Inferred from Electronic Annotation more info
postsynaptic density	IEA Inferred from Electronic Annotation more info
synapse	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: cysteine-rich PDZ-binding protein

Names: cysteine-rich PDZ-binding protein; postsynaptic protein CRIPT; cysteine-rich interactor of PDZ3; cysteine-rich interactor of PDZ three

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014171.4 → NP_054890.1 cysteine-rich PDZ-binding protein

Status: VALIDATED

Source sequence(s)

AC018682, AK291298

Consensus CDS

CCDS1829.1

UniProtKB/Swiss-Prot

Q9P021

Related

ENSP00000238892, OTTHUMP00000159029, ENST00000238892, OTTHUMT00000250748

Conserved Domains (1) summary

pfam10235
Location:11 – 101
Blast Score: 289

Cript; Microtubule-associated protein CRIPT

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

46844325..46852881

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

46581752..46590308

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC018682.4	AAY14836.1
genomic	CH471053.2	EAX00239.1
mRNA	AF161488.1	AAF29103.1
mRNA	AK291298.1	BAF83987.1
mRNA	BC006979.1	None
mRNA	BC006980.1	AAH06980.1
mRNA	BC018653.1	AAH18653.1
mRNA	BI857531.1	None
other-genetic	JF432435.1	ADZ15652.1