Tnfrsf21 tumor necrosis factor receptor superfamily, member 21 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Tnfrsf21provided by MGI
Official Full Name: tumor necrosis factor receptor superfamily, member 21provided by MGI
Primary source: MGI:2151075
See related: Ensembl:ENSMUSG00000023915
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DR6; TR7; R74815; AA959878

Genomic context

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Location :: 17; 17 C

Sequence :: Chromosome: 17; NC_000083.6 (43016555..43089188)

See Tnfrsf21 in Epigenomics, MapViewer

Chromosome 17 - NC_000083.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pla2g7 and Tnfrsf21 have been identified as genetic susceptibility to influenza genes in mice.
Title: Mapping of clinical and expression quantitative trait loci in a sex-dependent effect of host susceptibility to mouse-adapted influenza H3N2/HK/1/68.
role in oligodendrocyte survival, differentiation and myelination
Title: Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination.
findings show that DR6 expression is significantly but transiently upregulated only in activated both CD4+ and CD8+ T cells in NF-kappaB and NF-AT dependent manner with a contribution of PI3K-dependent signaling
Title: T-cell activation triggers death receptor-6 expression in a NF-κB and NF-AT dependent manner.
results indicate that APP and DR6 are components of a neuronal self-destruction pathway, and suggest that an extracellular fragment of APP, acting via DR6 and caspase 6, contributes to Alzheimer's disease
Title: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.
Death receptor 6 plays an important role in regulating leukocyte infiltration and function in the induction and progression of experimental autoimmune encephalomyelitis.
Title: Resistance to myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis by death receptor 6-deficient mice.
T cells lacking the DR6 receptor generate a severe form of acute graft-versus-host disease with accelerated onset, increased severity, rapid weight loss, and earlier organ damage and mortality.
Title: Accelerated onset and increased severity of acute graft-versus-host disease following adoptive transfer of DR6-deficient T cells.
Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6.
Title: Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6.
point to a critical role of DR6 in regulating airway inflammation in the ovalbumin-induced mouse model of asthma
Title: Death receptor-6 regulates the development of pulmonary eosinophilia and airway inflammation in a mouse model of asthma.

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Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (2) 1 citation
Targeted (Reporter) (1) 1 citation

Pathways from BioSystems

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Apoptosis, organism-specific biosystem (from WikiPathways)
Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PPARA Activates Gene Expression, organism-specific biosystem (from REACTOME)
PPARA Activates Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

RH125109 (e-PCR)
- UniSTS:161931

AA959878 (e-PCR)
- UniSTS:160661

Homology

Homologs of the Tnfrsf21 gene: The Tnfrsf21 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
apoptotic process	IEA Inferred from Electronic Annotation more info
neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
axon	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 21

Names: tumor necrosis factor receptor superfamily member 21; Death receptor 6; TNFR-related death receptor 6; TNFR-related death receptor-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178589.3 → NP_848704.1 tumor necrosis factor receptor superfamily member 21 precursor

Status: PROVISIONAL

Source sequence(s)

AK043823

Consensus CDS

CCDS28794.1

UniProtKB/TrEMBL

Q543Y9

UniProtKB/Swiss-Prot

Q9EPU5

Related

ENSMUSP00000024708, ENSMUST00000024708

Conserved Domains (3) summary

cd00185
Location:54 – 148
Blast Score: 228

TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...

cd08778
Location:414 – 497
Blast Score: 452

Death_TNFRSF21; Death domain of tumor necrosis factor receptor superfamily member 21

cl12111
Location:133 – 212
Blast Score: 117

TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000083.6 Reference GRCm38.p1 C57BL/6J

Range

43016555..43089188

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000039.1 Alternate Mm_Celera

Range

46437745..46511566

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01132763.1 (1720..2940)	None
genomic	AAHY01132764.1	None
genomic	AAHY01132765.1	None
genomic	AAHY01132766.1	None
genomic	AAHY01132767.1	None
genomic	AAHY01132768.1	None
genomic	AAHY01132769.1 (23977..36740)	None
genomic	AC154183.2	None
genomic	CH466559.1	EDL23398.1	mixed
genomic	CT486005.19 (38441..100486)	None
mRNA	AF322069.1	AAG38115.1	C57BL/6
mRNA	AK033529.1	BAC28342.1	C57BL/6J
mRNA	AK036984.1	None	C57BL/6J
mRNA	AK043823.1	BAC31664.1	C57BL/6J
mRNA	AK134704.1	BAE22249.1	C57BL/6J
mRNA	AK143175.1	BAE25292.1	C57BL/6J
mRNA	AY043489.1	AAK74193.1	BALB/c
mRNA	BC016420.1	AAH16420.1	FVB/N