LPXN leupaxin [Homo sapiens] - Gene

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Summary

Official Symbol: LPXNprovided by HGNC
Official Full Name: leupaxinprovided by HGNC
Primary source: HGNC:14061
See related: Ensembl:ENSG00000110031; HPRD:05651; MIM:605390; Vega:OTTHUMG00000167466
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LDPL
Summary: The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

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Genomic context

Location :: 11q12.1

Sequence :: Chromosome: 11; NC_000011.9 (58294344..58345639, complement)

See LPXN in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

first evidence of dynamic regulation of leupaxin localization and tyrosine phosphorylation by G-Protein Coupled Receptors
Title: Leupaxin is similar to paxillin in focal adhesion targeting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
leupaxin functions as a paxillin counterpart that potently suppresses the tyrosine phosphorylation of paxillin during integrin signaling.
Title: LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin.
LPXN, a member of the paxillin superfamily, is fused to RUNX1 in an acute myeloid leukemia patient with a t(11;21)(q12;q22) translocation.
Title: LPXN, a member of the paxillin superfamily, is fused to RUNX1 in an acute myeloid leukemia patient with a t(11;21)(q12;q22) translocation.
leupaxin could serve as a potential progression marker for a subset of PCa and may represent a novel coactivator of the androgen receptor
Title: Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells.
Leupaxin is enriched in vascular smooth nuscle. It undergoes cytoplasmic/nuclear shuttling & functions as an serum response factor cofactor. It associates with CArG-containing regions. Its ectopic expression induces smooth muscle marker gene expression.
Title: The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription.
Leupaxin plays an inhibitory role in BCR signaling and B cell function.
Title: Leupaxin negatively regulates B cell receptor signaling.
leupaxin may be a critical nucleating component of the osteoclast podosomal signaling complex
Title: Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast.
These data demonstrate that LPXN forms a signaling complex with Pyk2, c-Src, and PTP-PEST to regulate migration of prostate cancer cells.
Title: Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells.

Submit: New GeneRIF Correction See all (11)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_004802.1	NP_000876.1	ITGA4	BIND	PubMed	Leupaxin (LPXN) interacts with integrin alpha-4 (ITGA4).
O60711	P49639	HOXA1	HPRD	PubMed
O60711	Q9NV31	IMP3	HPRD	PubMed
O60711	P13612	ITGA4	HPRD	PubMed
O60711	P48059	LIMS1	HPRD	PubMed
O60711	BHC80	PHF21A	HPRD	PubMed
O60711	Q9Y2N3	POM121	HPRD	PubMed
O60711	Q05397	PTK2	HPRD	PubMed
O60711	Q14289	PTK2B	HPRD	PubMed
O60711	Q05209	PTPN12	HPRD	PubMed
O60711	Q9BUY5	ZNF426	HPRD	PubMed
BioGRID:114801	BioGRID:115330	HDAC6	BioGRID	PubMed	Two-hybrid
BioGRID:114801	BioGRID:109438	HOXA1	BioGRID	PubMed	Two-hybrid
BioGRID:114801	BioGRID:114089	IKBKG	BioGRID	PubMed	Reconstituted Complex
BioGRID:114801	BioGRID:120560	IMP3	BioGRID	PubMed	Two-hybrid
BioGRID:114801	BioGRID:110175	LIMS1	BioGRID	PubMed	Two-hybrid
BioGRID:114801	BioGRID:111583	MAPK6	BioGRID	PubMed	Two-hybrid
BioGRID:114801	BioGRID:119468	PHF21A	BioGRID	PubMed	Two-hybrid
BioGRID:114801	BioGRID:115214	POM121	BioGRID	PubMed	Two-hybrid
BioGRID:114801	BioGRID:111719	PTK2	BioGRID	PubMed	Two-hybrid
BioGRID:114801	BioGRID:108480	PTK2B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114801	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114801	BioGRID:122536	ZNF426	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
transcription cofactor activity	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cell adhesion	NAS Non-traceable Author Statement more info	PubMed
negative regulation of B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell adhesion	IDA Inferred from Direct Assay more info
protein complex assembly	TAS Traceable Author Statement more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
focal adhesion	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
podosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: leupaxin

Names: leupaxin

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001143995.1 → NP_001137467.1 leupaxin isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK300955, BU688891

Consensus CDS

CCDS53635.1

UniProtKB/Swiss-Prot

O60711

Related

ENSP00000431284, OTTHUMP00000235993, ENST00000528954, OTTHUMT00000394710

Conserved Domains (4) summary

cd09339
Location:334 – 385
Blast Score: 262

LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family.

cd09406
Location:155 – 209
Blast Score: 282

LIM1_Leupaxin; The first LIM domain of Leupaxin

cd09408
Location:216 – 267
Blast Score: 277

LIM2_Leupaxin; The second LIM domain of Leupaxin

cd09410
Location:275 – 327
Blast Score: 273

LIM3_Leupaxin; The third LIM domain of Leupaxin
NM_004811.2 → NP_004802.1 leupaxin isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) has a different first exon at the 5' end, compared to variant 1. This difference results in a unique 5' UTR and 5' coding region and an isoform (2) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AF062075, BP261314

Consensus CDS

CCDS7969.1

UniProtKB/Swiss-Prot

O60711

Related

ENSP00000378512, OTTHUMP00000235992, ENST00000395074, OTTHUMT00000394709

Conserved Domains (4) summary

cd09339
Location:329 – 380
Blast Score: 258

LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family.

cd09406
Location:150 – 204
Blast Score: 279

LIM1_Leupaxin; The first LIM domain of Leupaxin

cd09408
Location:211 – 262
Blast Score: 273

LIM2_Leupaxin; The second LIM domain of Leupaxin

cd09410
Location:270 – 322
Blast Score: 270

LIM3_Leupaxin; The third LIM domain of Leupaxin

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p5 Primary Assembly

Range

58294344..58345639, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

54641808..54693302, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP001350.4	None
genomic	AP003557.2 (67375..104835)	None
genomic	CH471076.1	EAW73807.1
		EAW73808.1
		EAW73809.1
mRNA	AF062075.1	AAC16014.1
mRNA	AK223165.1	BAD96885.1
mRNA	AK299264.1	BAH12983.1
mRNA	AK300955.1	BAG62583.1
mRNA	AK301093.1	BAG62693.1
mRNA	AK313306.1	BAG36111.1
mRNA	BC007490.1	None
mRNA	BC019035.2	AAH19035.1
mRNA	BC034230.1	None
mRNA	BP261314.1	None
mRNA	BU688891.1	None
mRNA	CR536531.1	CAG38768.1
other-genetic	DQ892705.2	ABM83631.1
other-genetic	DQ895954.2	ABM86880.1