My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    ACTR8 ARP8 actin-related protein 8 homolog (yeast) [ Homo sapiens ]

    Gene ID: 93973, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    ACTR8provided by HGNC
    Official Full Name
    ARP8 actin-related protein 8 homolog (yeast)provided by HGNC
    Primary source
    HGNC:14672
    See related
    Ensembl:ENSG00000113812; HPRD:09792; Vega:OTTHUMG00000158279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARP8; hArp8; INO80N; FLJ12934; FLJ22579
    Help top of page

    Genomic context

    Location :
    chromosome: 3
    Sequence :
    Chromosome: 3; NC_000003.11 (53901093..53916229, complement)
    See ACTR8 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene choline dehydrogenase Neighboring gene interleukin 17 receptor B Neighboring gene selenoprotein K Neighboring gene calcium binding tyrosine-(Y)-phosphorylation regulated pseudogene 1

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells. Vella P, et al. Nucleic Acids Res, 2012 Apr 1. PMID 22210892.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. Chen L, et al. J Biol Chem, 2011 Apr 1. PMID 21303910.
    4. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. Casabonne D, et al. Haematologica, 2011 Feb. PMID 21048031.
    5. The mammalian INO80 complex is recruited to DNA damage sites in an ARP8 dependent manner. Kashiwaba S, et al. Biochem Biophys Res Commun, 2010 Nov 26. PMID 20971067.

    See all (15) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. These results suggest that ARP8 is required for the recruitment of the mammalian INO80 complex to the laser-induced DNA damage sites.
      Title: The mammalian INO80 complex is recruited to DNA damage sites in an ARP8 dependent manner.
    2. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
    3. Expression of truncated hArp8 proteins and depletion of endogenous hArp8 by RNA interference caused misalignment of mitotic chromosomes, suggesting that chromosome-associated hArp8 has a role in chromosome behavior.
      Title: The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9H981 Q13873 BMPR2    HPRD  PubMed  
    BioGRID:125062 BioGRID:106601 ACTL6A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125062 BioGRID:122993 ACTR5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125062 BioGRID:120076 INO80    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125062 BioGRID:123646 INO80B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125062 BioGRID:125928 INO80C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125062 BioGRID:120238 INO80D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125062 BioGRID:129701 INO80E    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125062 BioGRID:115710 MCRS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125062 BioGRID:110864 NFRKB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125062 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125062 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125062 BioGRID:118931 TFPT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125062 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125062 BioGRID:119509 UCHL5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125062 BioGRID:113360 YY1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the ACTR8 gene: The ACTR8 gene is conserved in chimpanzee, , dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    actin-related protein 8
    Names
    actin-related protein 8
    INO80 complex subunit N
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022899.4 → NP_075050.3  actin-related protein 8

      Status: VALIDATED

      Source sequence(s)
      AC012467, AK022996, DA453867
      Consensus CDS
      CCDS2875.1
      UniProtKB/Swiss-Prot
      Q9H981
      Related
      ENSP00000336842, OTTHUMP00000212735, ENST00000335754, OTTHUMT00000350562
      Conserved Domains (1) summary
      cl11528
      Location:163 – 395
      Blast Score: 384
      ACTIN; Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      53901093..53916229, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      53949611..53964746, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC012467.9 (33936..49029) None
    genomic CH471055.1 EAW65300.1
    mRNA AK022996.1 BAB14352.1
    mRNA AK026232.1 BAB15402.1
    mRNA AK094507.1 BAG52879.1
    mRNA BC032744.1 AAH32744.1
    mRNA BU070174.1 None
    mRNA BX354684.2 None
    mRNA DA453867.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H981.2 GenPept UniProtKB/Swiss-Prot:Q9H981
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...