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Ube2n ubiquitin-conjugating enzyme E2N [ Mus musculus (house mouse) ]

Gene ID: 93765, updated on 8-May-2016
Official Symbol
Ube2nprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2Nprovided by MGI
Primary source
MGI:MGI:1934835
See related
Ensembl:ENSMUSG00000074781
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UBC13; AL022654; BB101821; 1500026J17Rik
Orthologs
Location:
10; 10 C2
Exon count:
5
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (95514706..95545658)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (94977796..95008292)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene 3619 Neighboring gene mitochondrial ribosomal protein L42 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 4 Neighboring gene microRNA 3058 Neighboring gene predicted gene, 33336

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ubiquitin conjugating enzyme activity IGI
Inferred from Genetic Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA double-strand break processing ISO
Inferred from Sequence Orthology
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
histone ubiquitination ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of histone modification ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
 
postreplication repair ISO
Inferred from Sequence Orthology
more info
 
protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
regulation of histone ubiquitination ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
UBC13-MMS2 complex ISO
Inferred from Sequence Orthology
more info
 
UBC13-UEV1A complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
ubiquitin-conjugating enzyme E2 N
Names
E2 ubiquitin-conjugating enzyme N
bendless-like ubiquitin-conjugating enzyme
ubiquitin carrier protein N
ubiquitin-protein ligase N
NP_542127.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080560.3NP_542127.1  ubiquitin-conjugating enzyme E2 N

    See identical proteins and their annotated locations for NP_542127.1

    Status: PROVISIONAL

    Source sequence(s)
    AC159135
    Consensus CDS
    CCDS48677.1
    UniProtKB/Swiss-Prot
    P61089
    UniProtKB/TrEMBL
    A2RTT4
    Related
    ENSMUSP00000096932, ENSMUST00000099329
    Conserved Domains (2) summary
    COG5078
    Location:3150
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:5144
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    95514706..95545658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514344.2XP_006514407.1  

    Conserved Domains (2) summary
    COG5078
    Location:30169
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:28163
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RNA

  1. XR_871735.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    97490812..97521349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)