Ube2n ubiquitin-conjugating enzyme E2N [Mus musculus] - Gene

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Summary

Official Symbol: Ube2nprovided by MGI
Official Full Name: ubiquitin-conjugating enzyme E2Nprovided by MGI
Primary source: MGI:1934835
See related: Ensembl:ENSMUSG00000074781
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UBC13; AL022654; BB101821; 1500026J17Rik

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Genomic context

Location :: 10 C2; 10

Sequence :: Chromosome: 10; NC_000076.6 (95515162..95545658)

See Ube2n in Epigenomics, MapViewer

Chromosome 10 - NC_000076.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results establish Ubc13 as a crucial regulator of hematopoiesis and suggest a role for Ubc13 in the control of Wnt signaling in hematopoietic stem cells.
Title: Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13.
modification of proteins with Lys(63)-linked ubiquitin chains occurs through a UEV1A-independent substrate modification and UEV1A-dependent Lys(63)-linked ubiquitin chain synthesis mechanism
Title: Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme.
Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses.
Title: Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses.
Ubc13 is key in the mammalian immune response.
Title: Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.

Submit: New GeneRIF Correction

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (1) 1 citation
Gene trapped (1) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:220301	BioGRID:204251	Cd40	BioGRID	PubMed	Affinity Capture-Western
BioGRID:220301	BioGRID:200602	Ikbkg	BioGRID	PubMed	Affinity Capture-Western
BioGRID:220301	BioGRID:204955	Map3k1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:220301	BioGRID:204962	Map3k7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:220301	BioGRID:206586	Tax1bp1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:220301	BioGRID:204224	Tlr4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:220301	BioGRID:204243	Tnfaip3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:220301	BioGRID:204303	Traf2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:220301	BioGRID:204307	Traf6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:220301	BioGRID:204323	Trp53	BioGRID	PubMed	Affinity Capture-Western
BioGRID:220301	BioGRID:113164	UBC	BioGRID	PubMed	Reconstituted Complex
BioGRID:220301	BioGRID:113184	UBE2V2	BioGRID	PubMed	Reconstituted Complex
BioGRID:220301	BioGRID:204403	Ubc	BioGRID	PubMed	Affinity Capture-Western
BioGRID:220301	BioGRID:211575	Ube2v1	BioGRID	PubMed	Two-hybrid
BioGRID:220301	BioGRID:214171	Ube2v2	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
acid-amino acid ligase activity	IEA Inferred from Electronic Annotation more info
ligase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin binding	ISO Inferred from Sequence Orthology more info
ubiquitin-protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
ubiquitin-protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
DNA double-strand break processing	ISO Inferred from Sequence Orthology more info
DNA repair	IEA Inferred from Electronic Annotation more info
T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
histone ubiquitination	ISO Inferred from Sequence Orthology more info
positive regulation of DNA repair	ISO Inferred from Sequence Orthology more info
positive regulation of I-kappaB kinase/NF-kappaB cascade	ISO Inferred from Sequence Orthology more info
positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of histone modification	ISO Inferred from Sequence Orthology more info
positive regulation of ubiquitin-protein ligase activity	ISO Inferred from Sequence Orthology more info
postreplication repair	ISO Inferred from Sequence Orthology more info
protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
protein ubiquitination	ISO Inferred from Sequence Orthology more info
regulation of histone ubiquitination	ISO Inferred from Sequence Orthology more info
response to DNA damage stimulus	IEA Inferred from Electronic Annotation more info
ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
UBC13-MMS2 complex	ISO Inferred from Sequence Orthology more info
UBC13-UEV1A complex	ISO Inferred from Sequence Orthology more info
cytoplasm	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: ubiquitin-conjugating enzyme E2 N

Names: ubiquitin-conjugating enzyme E2 N; ubiquitin-protein ligase N; ubiquitin carrier protein N; bendless-like ubiquitin-conjugating enzyme

NP_542127.1

EC 6.3.2.19

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080560.3 → NP_542127.1 ubiquitin-conjugating enzyme E2 N

Status: PROVISIONAL

Source sequence(s)

AC159135

Consensus CDS

CCDS48677.1

UniProtKB/TrEMBL

A2RTT4

UniProtKB/Swiss-Prot

P61089

Related

ENSMUSP00000096932, ENSMUST00000099329

Conserved Domains (1) summary

cd00195
Location:5 – 144
Blast Score: 449

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000076.6 Reference GRCm38 C57BL/6J

Range

95515162..95545658

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000032.1 Alternate Mm_Celera

Range

97490812..97521349

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC159135.11 (5269..35766)	None
genomic	CH466539.1	EDL21609.1	mixed
mRNA	AK005302.1	BAB23941.1	C57BL/6J
mRNA	AK005788.1	BAB24239.1	C57BL/6J
mRNA	AK150930.1	None	C57BL/6J
mRNA	AK161968.1	BAE36659.1	C57BL/6J
mRNA	AK213486.1	None
mRNA	AY039837.1	AAK74128.1	BALB/c
mRNA	BC034898.1	AAH34898.3
mRNA	BC052203.1	None
mRNA	BC067069.1	AAH67069.1	C57BL/6
mRNA	BC132630.1	AAI32631.1
mRNA	BC138211.1	AAI38212.1
mRNA	Y09873.1	CAA71001.1	ICR x Swiss Webster